| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-94 |
Sentence |
denotes |
Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells. |
| T2 |
95-360 |
Sentence |
denotes |
A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique. |
| T3 |
361-515 |
Sentence |
denotes |
Rab6c was found to be under-expressed in MCF7/AdrR and MES-SA/Dx5 (a human MDR uterine sarcoma cell line) compared with their non-MDR parental cell lines. |
| T4 |
516-734 |
Sentence |
denotes |
MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector. |
| T5 |
735-898 |
Sentence |
denotes |
Flow cytometry experiments confirmed that the transfectants' diminished resistance to DOX was caused by increased drug accumulation induced by the exogenous Rab6c. |
| T6 |
899-983 |
Sentence |
denotes |
These results indicate that Rab6c is involved in drug resistance in MCF7/AdrR cells. |
