LitCoin-sentences  

PubMed:10491763 JSONTXT 28 Projects

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Id Subject Object Predicate Lexical cue
T1 0-158 Sentence denotes Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion.
T2 159-175 Sentence denotes AIMS/HYPOTHESIS:
T3 176-346 Sentence denotes The transcription factor hepatocyte nuclear factor (HNF)-6 is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young.
T4 347-561 Sentence denotes We therefore tested the hypothesis that variability in the HNF-6 gene is associated with subsets of Type II (non-insulin-dependent) diabetes mellitus and estimates of insulin secretion in glucose tolerant subjects.
T5 562-570 Sentence denotes METHODS:
T6 571-655 Sentence denotes We cloned the coding region as well as the intron-exon boundaries of the HNF-6 gene.
T7 656-949 Sentence denotes We then examined them on genomic DNA in six MODY probands without mutations in the MODY1, MODY3 and MODY4 genes and in 54 patients with late-onset Type II diabetes by combined single strand conformational polymorphism-heteroduplex analysis followed by direct sequencing of identified variants.
T8 950-1048 Sentence denotes An identified missense variant was examined in association studies and genotype-phenotype studies.
T9 1049-1057 Sentence denotes RESULTS:
T10 1058-1120 Sentence denotes We identified two silent and one missense (Pro75 Ala) variant.
T11 1121-1369 Sentence denotes In an association study the allelic frequency of the Pro75Ala polymorphism was 3.2% (95% confidence interval, 1.9-4.5) in 330 patients with Type II diabetes mellitus compared with 4.2% (2.4-6.0) in 238 age-matched glucose tolerant control subjects.
T12 1370-1657 Sentence denotes Moreover, in studies of 238 middle-aged glucose tolerant subjects, of 226 glucose tolerant offspring of Type II diabetic patients and of 367 young healthy subjects, the carriers of the polymorphism did not differ from non-carriers in glucose induced serum insulin or C-peptide responses.
T13 1658-1684 Sentence denotes CONCLUSION/INTERPRETATION:
T14 1685-1853 Sentence denotes Mutations in the coding region of the HNF-6 gene are not associated with Type II diabetes or with changes in insulin responses to glucose among the Caucasians examined.