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PubMed:9973520 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-71 Sentence denotes Cross-linking of CD44 on rheumatoid synovial cells up-regulates VCAM-1.
T1 0-71 Sentence denotes Cross-linking of CD44 on rheumatoid synovial cells up-regulates VCAM-1.
T2 72-151 Sentence denotes CD44 is a ubiquitous molecule also known as hyaluronic acid or homing receptor.
T2 72-151 Sentence denotes CD44 is a ubiquitous molecule also known as hyaluronic acid or homing receptor.
T3 152-271 Sentence denotes However, the cellular functions and its role in inflammation, for example, rheumatoid synovitis, are currently unknown.
T3 152-271 Sentence denotes However, the cellular functions and its role in inflammation, for example, rheumatoid synovitis, are currently unknown.
T4 272-324 Sentence denotes In this study, we propose a novel function for CD44.
T4 272-324 Sentence denotes In this study, we propose a novel function for CD44.
T5 325-528 Sentence denotes Using synovial cells from rheumatoid arthritis (RA) patients, we demonstrated that CD44 cross-linking and binding to hyaluronan augmented VCAM-1 expression and subsequently VCAM-1-mediated cell adhesion.
T5 325-528 Sentence denotes Using synovial cells from rheumatoid arthritis (RA) patients, we demonstrated that CD44 cross-linking and binding to hyaluronan augmented VCAM-1 expression and subsequently VCAM-1-mediated cell adhesion.
T6 529-991 Sentence denotes Briefly, we found that 1) rheumatoid synovial cells highly expressed CD44; 2) cross-linking of CD44 markedly but transiently augmented VCAM-1 expression and its mRNA transcription much more than did IL-1beta and TNF-alpha; 3) hyaluronan, especially when fragmented, also up-regulated VCAM-1; 4) CD44 activated the transcription factor AP-1; and 5) the integrin-dependent adhesive function of RA synovial cells to T cells was also amplified by CD44 cross-linking.
T6 529-991 Sentence denotes Briefly, we found that 1) rheumatoid synovial cells highly expressed CD44; 2) cross-linking of CD44 markedly but transiently augmented VCAM-1 expression and its mRNA transcription much more than did IL-1beta and TNF-alpha; 3) hyaluronan, especially when fragmented, also up-regulated VCAM-1; 4) CD44 activated the transcription factor AP-1; and 5) the integrin-dependent adhesive function of RA synovial cells to T cells was also amplified by CD44 cross-linking.
T7 992-1263 Sentence denotes These results indicate that the adhesion of RA synovial cells to matrices such as hyaluronic acid through CD44 could up-regulate VCAM-1 expression and VCAM-1-mediated adhesion to T cells, which might in turn cause activation of T cells and synovial cells in RA synovitis.
T7 992-1263 Sentence denotes These results indicate that the adhesion of RA synovial cells to matrices such as hyaluronic acid through CD44 could up-regulate VCAM-1 expression and VCAM-1-mediated adhesion to T cells, which might in turn cause activation of T cells and synovial cells in RA synovitis.
T8 1264-1419 Sentence denotes We therefore propose that such cross-talking among distinct adhesion molecules may be involved in the pathogenesis of inflammation, including RA synovitis.
T8 1264-1419 Sentence denotes We therefore propose that such cross-talking among distinct adhesion molecules may be involved in the pathogenesis of inflammation, including RA synovitis.