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PubMed:9872676 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-69 Sentence denotes Interleukin-10 stabilizes inhibitory kappaB-alpha in human monocytes.
T1 0-69 Sentence denotes Interleukin-10 stabilizes inhibitory kappaB-alpha in human monocytes.
T2 70-134 Sentence denotes Interleukin-10 (IL-10) protects animals from lethal endotoxemia.
T2 70-134 Sentence denotes Interleukin-10 (IL-10) protects animals from lethal endotoxemia.
T3 135-281 Sentence denotes This beneficial effect is mediated, in part, by inhibition of inflammatory cytokine production, including tumor necrosis factor-alpha (TNF-alpha).
T3 135-281 Sentence denotes This beneficial effect is mediated, in part, by inhibition of inflammatory cytokine production, including tumor necrosis factor-alpha (TNF-alpha).
T4 282-425 Sentence denotes Evidence suggests that IL-10 may inhibit activation of the transcription factor nuclear factor-kappaB (NF-kappaB) through an unknown mechanism.
T4 282-425 Sentence denotes Evidence suggests that IL-10 may inhibit activation of the transcription factor nuclear factor-kappaB (NF-kappaB) through an unknown mechanism.
T5 426-591 Sentence denotes NF-kappaB activation in response to inflammatory signals is dependent upon degradation of its associated inhibitory peptide, inhibitory kappaB-alpha (IkappaB-alpha).
T5 426-591 Sentence denotes NF-kappaB activation in response to inflammatory signals is dependent upon degradation of its associated inhibitory peptide, inhibitory kappaB-alpha (IkappaB-alpha).
T6 592-733 Sentence denotes We hypothesized that IL-10 prevents human monocyte NF-kappaB activation and resultant TNF-alpha production by stabilization of IkappaB-alpha.
T6 592-733 Sentence denotes We hypothesized that IL-10 prevents human monocyte NF-kappaB activation and resultant TNF-alpha production by stabilization of IkappaB-alpha.
T7 734-922 Sentence denotes The purpose of this study was to determine the effect of IL-10 on lipopolysaccharide (LPS)-induced human monocyte TNF-alpha production, NF-kappaB activation, and IkappaB-alpha degradation.
T7 734-922 Sentence denotes The purpose of this study was to determine the effect of IL-10 on lipopolysaccharide (LPS)-induced human monocyte TNF-alpha production, NF-kappaB activation, and IkappaB-alpha degradation.
T8 923-965 Sentence denotes Monocytes were isolated from human donors.
T8 923-965 Sentence denotes Monocytes were isolated from human donors.
T9 966-1060 Sentence denotes Cells were stimulated with endotoxin (LPS, 100 ng/mL) with and without human IL-10 (10 ng/mL).
T9 966-1060 Sentence denotes Cells were stimulated with endotoxin (LPS, 100 ng/mL) with and without human IL-10 (10 ng/mL).
T10 1061-1239 Sentence denotes Following stimulation, TNF-alpha was measured in cell supernatants by ELISA, NF-kappaB activity by electrophoretic mobility shift assay, and IkappaB-alpha levels by Western blot.
T10 1061-1239 Sentence denotes Following stimulation, TNF-alpha was measured in cell supernatants by ELISA, NF-kappaB activity by electrophoretic mobility shift assay, and IkappaB-alpha levels by Western blot.
T11 1240-1363 Sentence denotes We observed that after LPS stimulation of human monocytes, TNF-alpha increased to 798+/-67 pg/mL (p < .001 versus control).
T11 1240-1363 Sentence denotes We observed that after LPS stimulation of human monocytes, TNF-alpha increased to 798+/-67 pg/mL (p < .001 versus control).
T12 1364-1455 Sentence denotes IL-10 attenuated LPS-stimulated TNF-alpha production (297+/-54; p < .001 versus LPS alone).
T12 1364-1455 Sentence denotes IL-10 attenuated LPS-stimulated TNF-alpha production (297+/-54; p < .001 versus LPS alone).
T13 1456-1574 Sentence denotes After LPS stimulation in human monocytes, IkappaB-alpha protein levels decreased, and NF-kappaB DNA binding increased.
T13 1456-1574 Sentence denotes After LPS stimulation in human monocytes, IkappaB-alpha protein levels decreased, and NF-kappaB DNA binding increased.
T14 1575-1695 Sentence denotes IL-10 pretreatment prevented LPS-induced decreases in IkappaB-alpha protein levels and attenuated NF-kappaB DNA binding.
T14 1575-1695 Sentence denotes IL-10 pretreatment prevented LPS-induced decreases in IkappaB-alpha protein levels and attenuated NF-kappaB DNA binding.
T15 1696-1833 Sentence denotes IL-10 appears to prevent activation of NF-kappaB by preserving IkappaB-alpha protein levels, leading to a reduction in TNF-alpha release.
T15 1696-1833 Sentence denotes IL-10 appears to prevent activation of NF-kappaB by preserving IkappaB-alpha protein levels, leading to a reduction in TNF-alpha release.