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PubMed:9834272 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-122 Sentence denotes Epithelial cell-initiated inflammation plays a crucial role in early tissue damage in amebic infection of human intestine.
T1 0-122 Sentence denotes Epithelial cell-initiated inflammation plays a crucial role in early tissue damage in amebic infection of human intestine.
T2 123-141 Sentence denotes BACKGROUND & AIMS:
T2 123-141 Sentence denotes BACKGROUND & AIMS:
T3 142-226 Sentence denotes Entamoeba histolytica infection of the intestine can induce severe gut inflammation.
T3 142-226 Sentence denotes Entamoeba histolytica infection of the intestine can induce severe gut inflammation.
T4 227-428 Sentence denotes The aims of this study were to assess the role of the host inflammatory response in the tissue damage observed with amebiasis and the role of the intestinal epithelial cell in initiating that response.
T4 227-428 Sentence denotes The aims of this study were to assess the role of the host inflammatory response in the tissue damage observed with amebiasis and the role of the intestinal epithelial cell in initiating that response.
T5 429-564 Sentence denotes METHODS: E. histolytica infection was established in human intestinal xenografts in severe combined immunodeficient (SCID-HU-INT) mice.
T5 429-564 Sentence denotes METHODS: E. histolytica infection was established in human intestinal xenografts in severe combined immunodeficient (SCID-HU-INT) mice.
T6 565-902 Sentence denotes Human intestinal epithelial cell inflammatory responses to amebic infection were inhibited by the intraluminal administration of an antisense oligonucleotide to the human p65 subunit of nuclear factor kappaB, and the role of neutrophils in tissue damage observed with amebiasis was studied by depleting neutrophils from SCID-HU-INT mice.
T6 565-902 Sentence denotes Human intestinal epithelial cell inflammatory responses to amebic infection were inhibited by the intraluminal administration of an antisense oligonucleotide to the human p65 subunit of nuclear factor kappaB, and the role of neutrophils in tissue damage observed with amebiasis was studied by depleting neutrophils from SCID-HU-INT mice.
T7 903-911 Sentence denotes RESULTS:
T7 903-911 Sentence denotes RESULTS:
T8 912-1146 Sentence denotes Administration of the antisense oligonucleotide blocked the production of human interleukin 1beta and interleukin 8 by intestinal epithelial cells and inhibited neutrophil influx into the E. histolytica-infected intestinal xenografts.
T8 912-1146 Sentence denotes Administration of the antisense oligonucleotide blocked the production of human interleukin 1beta and interleukin 8 by intestinal epithelial cells and inhibited neutrophil influx into the E. histolytica-infected intestinal xenografts.
T9 1147-1357 Sentence denotes Inhibition of the gut inflammatory response by the antisense oligonucleotide or the depletion of neutrophils from SCID-HU-INT mice blocked the increase in intestinal permeability observed with amebic infection.
T9 1147-1357 Sentence denotes Inhibition of the gut inflammatory response by the antisense oligonucleotide or the depletion of neutrophils from SCID-HU-INT mice blocked the increase in intestinal permeability observed with amebic infection.
T10 1358-1370 Sentence denotes CONCLUSIONS:
T10 1358-1370 Sentence denotes CONCLUSIONS:
T11 1371-1640 Sentence denotes Intestinal epithelial cells initiate an inflammatory response with resulting neutrophil-mediated tissue damage in response to E. histolytica infection; this inflammatory cascade can be blocked by inhibiting the transcription of genes regulated by nuclear factor kappaB.
T11 1371-1640 Sentence denotes Intestinal epithelial cells initiate an inflammatory response with resulting neutrophil-mediated tissue damage in response to E. histolytica infection; this inflammatory cascade can be blocked by inhibiting the transcription of genes regulated by nuclear factor kappaB.