| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-65 |
Sentence |
denotes |
[Molecular mechanism of cytokine gene expression in Th1 and Th2]. |
| T1 |
0-65 |
Sentence |
denotes |
[Molecular mechanism of cytokine gene expression in Th1 and Th2]. |
| T2 |
66-214 |
Sentence |
denotes |
Upon activation by antigens, helper T cells differentiate into one of several subsets, characterized by their distinct cytokine-production patterns. |
| T2 |
66-214 |
Sentence |
denotes |
Upon activation by antigens, helper T cells differentiate into one of several subsets, characterized by their distinct cytokine-production patterns. |
| T3 |
215-404 |
Sentence |
denotes |
Among these subsets, Th1 cells are known to activate cellular immunity resulting in inflammatory response, whereas Th2 cells induce humoral and allergic responses and suppress inflammation. |
| T3 |
215-404 |
Sentence |
denotes |
Among these subsets, Th1 cells are known to activate cellular immunity resulting in inflammatory response, whereas Th2 cells induce humoral and allergic responses and suppress inflammation. |
| T4 |
405-522 |
Sentence |
denotes |
Th1 and Th2 effector functions and their development are attributable to their distinct cytokine expression patterns. |
| T4 |
405-522 |
Sentence |
denotes |
Th1 and Th2 effector functions and their development are attributable to their distinct cytokine expression patterns. |
| T5 |
523-715 |
Sentence |
denotes |
Recent reports have demonstrated that differential expression of cell surface molecules, such as adhesion molecule and chemokine receptor, is involved in their recruitment into target tissues. |
| T5 |
523-715 |
Sentence |
denotes |
Recent reports have demonstrated that differential expression of cell surface molecules, such as adhesion molecule and chemokine receptor, is involved in their recruitment into target tissues. |
| T6 |
716-906 |
Sentence |
denotes |
It is, therefore, suggested that clarification of the mechanisms of differential gene expression in Th1/Th2 should lead to rational strategies for manipulating pathological immune responses. |
| T6 |
716-906 |
Sentence |
denotes |
It is, therefore, suggested that clarification of the mechanisms of differential gene expression in Th1/Th2 should lead to rational strategies for manipulating pathological immune responses. |
| T7 |
907-1007 |
Sentence |
denotes |
Activation of helper T cells mediated by the T cell receptor induces a series of biochemical events. |
| T7 |
907-1007 |
Sentence |
denotes |
Activation of helper T cells mediated by the T cell receptor induces a series of biochemical events. |
| T8 |
1008-1156 |
Sentence |
denotes |
Among them, both the activation of PKC/Ras- and CaM/CN-mediated pathways play a central role in the signal transduction of cytokine gene expression. |
| T8 |
1008-1156 |
Sentence |
denotes |
Among them, both the activation of PKC/Ras- and CaM/CN-mediated pathways play a central role in the signal transduction of cytokine gene expression. |
| T9 |
1157-1342 |
Sentence |
denotes |
Closer examination using non-transformed murine Th1 and Th2 clones suggested that a balance between the activities of the two signaling pathways contributes to cytokine gene expression. |
| T9 |
1157-1342 |
Sentence |
denotes |
Closer examination using non-transformed murine Th1 and Th2 clones suggested that a balance between the activities of the two signaling pathways contributes to cytokine gene expression. |
| T10 |
1343-1479 |
Sentence |
denotes |
We propose that one of the targets of PGE2, whose effect distinguishes Th1 from Th2, resides in the downstream PKC/Ras-mediated pathway. |
| T10 |
1343-1479 |
Sentence |
denotes |
We propose that one of the targets of PGE2, whose effect distinguishes Th1 from Th2, resides in the downstream PKC/Ras-mediated pathway. |