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PubMed:9743506 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-149 Sentence denotes Activated platelets induce monocyte chemotactic protein-1 secretion and surface expression of intercellular adhesion molecule-1 on endothelial cells.
T1 0-149 Sentence denotes Activated platelets induce monocyte chemotactic protein-1 secretion and surface expression of intercellular adhesion molecule-1 on endothelial cells.
T2 150-161 Sentence denotes BACKGROUND:
T2 150-161 Sentence denotes BACKGROUND:
T3 162-278 Sentence denotes Platelet/endothelium interaction plays an important role in the pathophysiology of inflammation and atherosclerosis.
T3 162-278 Sentence denotes Platelet/endothelium interaction plays an important role in the pathophysiology of inflammation and atherosclerosis.
T4 279-462 Sentence denotes The role of platelets for monocyte chemotactic protein-1 (MCP-1) secretion and surface expression of intercellular adhesion molecule-1 (ICAM-1) on endothelial cells has been assessed.
T4 279-462 Sentence denotes The role of platelets for monocyte chemotactic protein-1 (MCP-1) secretion and surface expression of intercellular adhesion molecule-1 (ICAM-1) on endothelial cells has been assessed.
T5 463-483 Sentence denotes METHODS AND RESULTS:
T5 463-483 Sentence denotes METHODS AND RESULTS:
T6 484-725 Sentence denotes Monolayers of human umbilical vein endothelial cells were incubated with nonstimulated or ADP-activated platelets for 6 hours, and secretion of MCP-1 and surface expression of ICAM-1 were determined by ELISA and flow cytometry, respectively.
T6 484-725 Sentence denotes Monolayers of human umbilical vein endothelial cells were incubated with nonstimulated or ADP-activated platelets for 6 hours, and secretion of MCP-1 and surface expression of ICAM-1 were determined by ELISA and flow cytometry, respectively.
T7 726-897 Sentence denotes In the presence of ADP-activated platelets, both MCP-1 secretion and ICAM-1 surface expression were significantly increased compared with nonstimulated platelets (P<0.02).
T7 726-897 Sentence denotes In the presence of ADP-activated platelets, both MCP-1 secretion and ICAM-1 surface expression were significantly increased compared with nonstimulated platelets (P<0.02).
T8 898-1120 Sentence denotes Activation of the transcription factor nuclear factor-kappaB (NF-kappaB) determined by electrophoretic mobility shift assay and kappaB-dependent transcriptional activity was enhanced in the presence of activated platelets.
T8 898-1120 Sentence denotes Activation of the transcription factor nuclear factor-kappaB (NF-kappaB) determined by electrophoretic mobility shift assay and kappaB-dependent transcriptional activity was enhanced in the presence of activated platelets.
T9 1121-1216 Sentence denotes In addition, ADP-activated platelets induced MCP-1 and ICAM-1 promoter-dependent transcription.
T9 1121-1216 Sentence denotes In addition, ADP-activated platelets induced MCP-1 and ICAM-1 promoter-dependent transcription.
T10 1217-1424 Sentence denotes Liposomal transfection of a double-stranded kappaB phosphorothioate oligonucleotide, but not of the mutated form, inhibited MCP-1 secretion and surface expression of ICAM-1 on activated endothelium (P<0.05).
T10 1217-1424 Sentence denotes Liposomal transfection of a double-stranded kappaB phosphorothioate oligonucleotide, but not of the mutated form, inhibited MCP-1 secretion and surface expression of ICAM-1 on activated endothelium (P<0.05).
T11 1425-1437 Sentence denotes CONCLUSIONS:
T11 1425-1437 Sentence denotes CONCLUSIONS:
T12 1438-1611 Sentence denotes The present study indicates that activated platelets modulate chemotactic (MCP-1) and adhesive (ICAM-1) properties of endothelial cells via an NF-kappaB-dependent mechanism.
T12 1438-1611 Sentence denotes The present study indicates that activated platelets modulate chemotactic (MCP-1) and adhesive (ICAM-1) properties of endothelial cells via an NF-kappaB-dependent mechanism.
T13 1612-1727 Sentence denotes Platelet-induced activation of the NF-kappaB system might contribute to early inflammatory events in atherogenesis.
T13 1612-1727 Sentence denotes Platelet-induced activation of the NF-kappaB system might contribute to early inflammatory events in atherogenesis.