| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-153 |
Sentence |
denotes |
Inhibition of nuclear factor kappa B subunit p65 mRNA accumulation in lipopolysaccharide-stimulated human monocytic cells treated with sodium salicylate. |
| T1 |
0-153 |
Sentence |
denotes |
Inhibition of nuclear factor kappa B subunit p65 mRNA accumulation in lipopolysaccharide-stimulated human monocytic cells treated with sodium salicylate. |
| T2 |
154-340 |
Sentence |
denotes |
Lipopolysaccharide is one of the most potent trigger substances for monocytes and macrophages causing secretion of inflammatory mediators such as tumor necrosis factor and interleukin-1. |
| T2 |
154-340 |
Sentence |
denotes |
Lipopolysaccharide is one of the most potent trigger substances for monocytes and macrophages causing secretion of inflammatory mediators such as tumor necrosis factor and interleukin-1. |
| T3 |
341-439 |
Sentence |
denotes |
The nature of the nuclear factors involved in regulation of these cytokine genes is still unknown. |
| T3 |
341-439 |
Sentence |
denotes |
The nature of the nuclear factors involved in regulation of these cytokine genes is still unknown. |
| T4 |
440-661 |
Sentence |
denotes |
Nuclear factor kappa B (NF-kappa B; heterodimer of p50 and p65) proteins have been suggested to play an important role in gene transcription of inflammatory mediators when monocytes are stimulated with lipopolysaccharide. |
| T4 |
440-661 |
Sentence |
denotes |
Nuclear factor kappa B (NF-kappa B; heterodimer of p50 and p65) proteins have been suggested to play an important role in gene transcription of inflammatory mediators when monocytes are stimulated with lipopolysaccharide. |
| T5 |
662-827 |
Sentence |
denotes |
Nonsteroidal anti-inflammatory drugs such as salicylates have been used to treat symptoms of inflammation, and a new mechanism of drug action was suggested recently. |
| T5 |
662-827 |
Sentence |
denotes |
Nonsteroidal anti-inflammatory drugs such as salicylates have been used to treat symptoms of inflammation, and a new mechanism of drug action was suggested recently. |
| T6 |
828-1090 |
Sentence |
denotes |
Salicylates have been shown to inhibit lipopolysaccharide-induced gene transcription via inhibition of NF-kappa B activation by preventing the degradation of NF-kappa B inhibitor "I kappa B", blocking the translocation of NF-kappa B into the nuclear compartment. |
| T6 |
828-1090 |
Sentence |
denotes |
Salicylates have been shown to inhibit lipopolysaccharide-induced gene transcription via inhibition of NF-kappa B activation by preventing the degradation of NF-kappa B inhibitor "I kappa B", blocking the translocation of NF-kappa B into the nuclear compartment. |
| T7 |
1091-1174 |
Sentence |
denotes |
However, the nature of the subunit involved in this mechanism has not been defined. |
| T7 |
1091-1174 |
Sentence |
denotes |
However, the nature of the subunit involved in this mechanism has not been defined. |
| T8 |
1175-1417 |
Sentence |
denotes |
To examine the mechanisms by which salicylates affect cytokine gene transcription, the amount of active and inactive NF-kappa B and NF-kappa B mRNA, in Porphyromonas gingivalis lipopolysaccharide-stimulated human monocytic cells was assessed. |
| T8 |
1175-1417 |
Sentence |
denotes |
To examine the mechanisms by which salicylates affect cytokine gene transcription, the amount of active and inactive NF-kappa B and NF-kappa B mRNA, in Porphyromonas gingivalis lipopolysaccharide-stimulated human monocytic cells was assessed. |
| T9 |
1418-1638 |
Sentence |
denotes |
High doses of sodium salicylate suppressed NF-kappa B p65 mRNA accumulation, resulting in suppression of total NF-kappa B, p50 on tissue oligonucleotide had no effects on lipopolysaccharide-induced NF-kappa B activation. |
| T9 |
1418-1638 |
Sentence |
denotes |
High doses of sodium salicylate suppressed NF-kappa B p65 mRNA accumulation, resulting in suppression of total NF-kappa B, p50 on tissue oligonucleotide had no effects on lipopolysaccharide-induced NF-kappa B activation. |
| T10 |
1639-1829 |
Sentence |
denotes |
The data demonstrate that the p65 subunit of NF-kappa B is inhibited by salicylate treatment and highlight the role of salicylate in the control of gene expression of inflammatory mediators. |
| T10 |
1639-1829 |
Sentence |
denotes |
The data demonstrate that the p65 subunit of NF-kappa B is inhibited by salicylate treatment and highlight the role of salicylate in the control of gene expression of inflammatory mediators. |