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PubMed:9440546 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T1 0-124 Sentence denotes Cellular and molecular mechanisms of IL-5 synthesis in atopic diseases: a study with allergen-specific human helper T cells.
T1 0-124 Sentence denotes Cellular and molecular mechanisms of IL-5 synthesis in atopic diseases: a study with allergen-specific human helper T cells.
T2 125-136 Sentence denotes BACKGROUND:
T2 125-136 Sentence denotes BACKGROUND:
T3 137-269 Sentence denotes Cytokines produced by helper T cells are intimately involved in chronic allergic diseases associated with eosinophilic inflammation.
T3 137-269 Sentence denotes Cytokines produced by helper T cells are intimately involved in chronic allergic diseases associated with eosinophilic inflammation.
T4 270-280 Sentence denotes OBJECTIVE:
T4 270-280 Sentence denotes OBJECTIVE:
T5 281-430 Sentence denotes We investigated the production of IL-5, a potent growth factor and chemotactic factor for eosinophils, by CD4+ T lymphocytes in patients with asthma.
T5 281-430 Sentence denotes We investigated the production of IL-5, a potent growth factor and chemotactic factor for eosinophils, by CD4+ T lymphocytes in patients with asthma.
T6 431-439 Sentence denotes METHODS:
T6 431-439 Sentence denotes METHODS:
T7 440-627 Sentence denotes Allergen-specific T cell clones and T cell hybridomas were established from the peripheral blood lymphocytes of patients with asthma, and the responses to various stimuli were determined.
T7 440-627 Sentence denotes Allergen-specific T cell clones and T cell hybridomas were established from the peripheral blood lymphocytes of patients with asthma, and the responses to various stimuli were determined.
T8 628-636 Sentence denotes RESULTS:
T8 628-636 Sentence denotes RESULTS:
T9 637-829 Sentence denotes After nonspecific stimulation, IL-5 production by CD4+ T cells from both atopic and nonatopic subjects with asthma was significantly enhanced compared with that by cells from healthy controls.
T9 637-829 Sentence denotes After nonspecific stimulation, IL-5 production by CD4+ T cells from both atopic and nonatopic subjects with asthma was significantly enhanced compared with that by cells from healthy controls.
T10 830-1075 Sentence denotes Peripheral blood mononuclear cells from atopic asthma patients both proliferated and produced IL-5 after incubation with mite allergen, suggesting that mite-specific helper T cells were involved in the eosinophilic inflammation of atopic asthma.
T10 830-1075 Sentence denotes Peripheral blood mononuclear cells from atopic asthma patients both proliferated and produced IL-5 after incubation with mite allergen, suggesting that mite-specific helper T cells were involved in the eosinophilic inflammation of atopic asthma.
T11 1076-1376 Sentence denotes A human IL-5 promoter/enhancer luciferase gene construct transfected into IL-5-producing T cell clones was clearly transcribed after stimulation, indicating that the 515 base pair IL-5 gene segment upstream of the coding region was sufficient to respond to activating signals in human helper T cells.
T11 1076-1376 Sentence denotes A human IL-5 promoter/enhancer luciferase gene construct transfected into IL-5-producing T cell clones was clearly transcribed after stimulation, indicating that the 515 base pair IL-5 gene segment upstream of the coding region was sufficient to respond to activating signals in human helper T cells.
T12 1377-1541 Sentence denotes The same gene segment was not transcribed in IL-5-nonproducing T cell clones, suggesting that human T cell IL-5 synthesis is regulated at the transcriptional level.
T12 1377-1541 Sentence denotes The same gene segment was not transcribed in IL-5-nonproducing T cell clones, suggesting that human T cell IL-5 synthesis is regulated at the transcriptional level.
T13 1542-1702 Sentence denotes Experiments with T cell hybridomas confirmed these findings and suggested that a unique transcription factor may be essential for human IL-5 gene transcription.
T13 1542-1702 Sentence denotes Experiments with T cell hybridomas confirmed these findings and suggested that a unique transcription factor may be essential for human IL-5 gene transcription.
T14 1703-1714 Sentence denotes CONCLUSION:
T14 1703-1714 Sentence denotes CONCLUSION:
T15 1715-1839 Sentence denotes Enhanced IL-5 production by helper T cells seems to cause the eosinophilic inflammation of both atopic and nonatopic asthma.
T15 1715-1839 Sentence denotes Enhanced IL-5 production by helper T cells seems to cause the eosinophilic inflammation of both atopic and nonatopic asthma.
T16 1840-2006 Sentence denotes Elucidation of IL-5-specific regulatory mechanisms may facilitate the development of novel treatments for allergic diseases associated with eosinophilic inflammation.
T16 1840-2006 Sentence denotes Elucidation of IL-5-specific regulatory mechanisms may facilitate the development of novel treatments for allergic diseases associated with eosinophilic inflammation.