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PubMed:9374642 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-94 Sentence denotes Hypoxia enhances induction of endothelial ICAM-1: role for metabolic acidosis and proteasomes.
T1 0-94 Sentence denotes Hypoxia enhances induction of endothelial ICAM-1: role for metabolic acidosis and proteasomes.
T2 95-255 Sentence denotes Intercellular adhesion molecule 1 (ICAM-1) is an important molecule in promotion of polymorphonuclear neutrophil transendothelial migration during inflammation.
T2 95-255 Sentence denotes Intercellular adhesion molecule 1 (ICAM-1) is an important molecule in promotion of polymorphonuclear neutrophil transendothelial migration during inflammation.
T3 256-317 Sentence denotes Coincident with many inflammatory diseases is tissue hypoxia.
T3 256-317 Sentence denotes Coincident with many inflammatory diseases is tissue hypoxia.
T4 318-454 Sentence denotes Thus we hypothesized that combinations of hypoxia and inflammatory stimuli may differentially regulate expression of endothelial ICAM-1.
T4 318-454 Sentence denotes Thus we hypothesized that combinations of hypoxia and inflammatory stimuli may differentially regulate expression of endothelial ICAM-1.
T5 455-613 Sentence denotes Human endothelial cells were exposed to hypoxia in the presence or absence of added lipopolysaccharide (LPS) and examined for expression of functional ICAM-1.
T5 455-613 Sentence denotes Human endothelial cells were exposed to hypoxia in the presence or absence of added lipopolysaccharide (LPS) and examined for expression of functional ICAM-1.
T6 614-753 Sentence denotes Although hypoxia alone did not induce ICAM-1, the combination of LPS and hypoxia enhanced (3 +/- 0.4-fold over normoxia) ICAM-1 expression.
T6 614-753 Sentence denotes Although hypoxia alone did not induce ICAM-1, the combination of LPS and hypoxia enhanced (3 +/- 0.4-fold over normoxia) ICAM-1 expression.
T7 754-932 Sentence denotes Combinations of hypoxia and LPS significantly increased lymphocyte binding, and such increases were inhibited by addition of anti-ICAM-1 antibodies or antisense oligonucleotides.
T7 754-932 Sentence denotes Combinations of hypoxia and LPS significantly increased lymphocyte binding, and such increases were inhibited by addition of anti-ICAM-1 antibodies or antisense oligonucleotides.
T8 933-1201 Sentence denotes Hypoxic endothelia showed a > 10-fold increase in sensitivity to inhibitors of proteasome activation, and combinations of hypoxia and LPS enhanced proteasome-dependent cytoplasmic-to-nuclear localization of the nuclear transcription factor-kappa B p65 (Rel A) subunit.
T8 933-1201 Sentence denotes Hypoxic endothelia showed a > 10-fold increase in sensitivity to inhibitors of proteasome activation, and combinations of hypoxia and LPS enhanced proteasome-dependent cytoplasmic-to-nuclear localization of the nuclear transcription factor-kappa B p65 (Rel A) subunit.
T9 1202-1313 Sentence denotes Such proteasome activation correlated with hypoxia-evoked decreases in both extracellular and intracellular pH.
T9 1202-1313 Sentence denotes Such proteasome activation correlated with hypoxia-evoked decreases in both extracellular and intracellular pH.
T10 1314-1439 Sentence denotes We conclude from these studies that endothelial hypoxia provides a novel, proteasome-dependent stimulus for ICAM-1 induction.
T10 1314-1439 Sentence denotes We conclude from these studies that endothelial hypoxia provides a novel, proteasome-dependent stimulus for ICAM-1 induction.