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PubMed:9348314 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-102 Sentence denotes Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta.
T1 0-102 Sentence denotes Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta.
T2 103-264 Sentence denotes In many chronic inflammatory disorders, glucocorticoid (GC) insensitivity is a challenging clinical problem associated with life-threatening disease progression.
T2 103-264 Sentence denotes In many chronic inflammatory disorders, glucocorticoid (GC) insensitivity is a challenging clinical problem associated with life-threatening disease progression.
T3 265-326 Sentence denotes The molecular basis of GC insensitivity, however, is unknown.
T3 265-326 Sentence denotes The molecular basis of GC insensitivity, however, is unknown.
T4 327-536 Sentence denotes Alternative splicing of the GC receptor (R) pre-messenger RNA generates a second GCR, termed GCR-beta, which does not bind GCs but antagonizes the transactivating activity of the classic GCR, termed GCR-alpha.
T4 327-536 Sentence denotes Alternative splicing of the GC receptor (R) pre-messenger RNA generates a second GCR, termed GCR-beta, which does not bind GCs but antagonizes the transactivating activity of the classic GCR, termed GCR-alpha.
T5 537-751 Sentence denotes In the current study, we demonstrate that GC-insensitive asthma is associated with a significantly higher number of GCR-beta-immunoreactive cells in peripheral blood than GC-sensitive asthmatics or normal controls.
T5 537-751 Sentence denotes In the current study, we demonstrate that GC-insensitive asthma is associated with a significantly higher number of GCR-beta-immunoreactive cells in peripheral blood than GC-sensitive asthmatics or normal controls.
T6 752-891 Sentence denotes Furthermore, we show that patients with GC-insensitive asthma have cytokine-induced abnormalities in the DNA binding capability of the GCR.
T6 752-891 Sentence denotes Furthermore, we show that patients with GC-insensitive asthma have cytokine-induced abnormalities in the DNA binding capability of the GCR.
T7 892-1058 Sentence denotes These abnormalities can be reproduced by transfection of cell lines with the GCR-beta gene resulting in significant reduction of their GCR-alpha DNA binding capacity.
T7 892-1058 Sentence denotes These abnormalities can be reproduced by transfection of cell lines with the GCR-beta gene resulting in significant reduction of their GCR-alpha DNA binding capacity.
T8 1059-1206 Sentence denotes We conclude that increased expression of GCR-beta is cytokine inducible and may account for GC insensitivity in this common inflammatory condition.
T8 1059-1206 Sentence denotes We conclude that increased expression of GCR-beta is cytokine inducible and may account for GC insensitivity in this common inflammatory condition.