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PubMed:9341756 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T1 0-189 Sentence denotes Induction of endothelial cell surface adhesion molecules by tumor necrosis factor is blocked by protein tyrosine phosphatase inhibitors: role of the nuclear transcription factor NF-kappa B.
T1 0-189 Sentence denotes Induction of endothelial cell surface adhesion molecules by tumor necrosis factor is blocked by protein tyrosine phosphatase inhibitors: role of the nuclear transcription factor NF-kappa B.
T2 190-466 Sentence denotes Recent studies from our laboratory have indicated that protein tyrosine phosphatase (PTPase) inhibitors can down-modulate the tumor necrosis factor (TNF)-mediated activation of the nuclear transcription factor NF-kappa B in ML-1a, a monocytic cell line (Singh and Aggarwal, J.
T2 190-466 Sentence denotes Recent studies from our laboratory have indicated that protein tyrosine phosphatase (PTPase) inhibitors can down-modulate the tumor necrosis factor (TNF)-mediated activation of the nuclear transcription factor NF-kappa B in ML-1a, a monocytic cell line (Singh and Aggarwal, J.
T3 467-472 Sentence denotes Biol.
T3 467-472 Sentence denotes Biol.
T4 473-478 Sentence denotes Chem.
T4 473-478 Sentence denotes Chem.
T5 479-484 Sentence denotes 1995:
T5 479-484 Sentence denotes 1995:
T6 485-489 Sentence denotes 270:
T6 485-489 Sentence denotes 270:
T7 490-497 Sentence denotes 10631).
T7 490-497 Sentence denotes 10631).
T8 498-878 Sentence denotes Since TNF is one of the major inducers of various adhesion molecules in human endothelial cells and their expression is known to require the activation of NF-kappa B, we examined the effect of PTPase inhibitors on the TNF-mediated induction of intracellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1 and endothelial leukocyte adhesion molecule (ELAM)-1.
T8 498-878 Sentence denotes Since TNF is one of the major inducers of various adhesion molecules in human endothelial cells and their expression is known to require the activation of NF-kappa B, we examined the effect of PTPase inhibitors on the TNF-mediated induction of intracellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1 and endothelial leukocyte adhesion molecule (ELAM)-1.
T9 879-1119 Sentence denotes Like ML-1a, human dermal microvessel endothelial cells (MVEC) treated with TNF rapidly activated (within 30 min) NF-kappa B; this effect was completely abolished by co-treatment with phenylarsine oxide (PAO), a specific inhibitor of PTPase.
T9 879-1119 Sentence denotes Like ML-1a, human dermal microvessel endothelial cells (MVEC) treated with TNF rapidly activated (within 30 min) NF-kappa B; this effect was completely abolished by co-treatment with phenylarsine oxide (PAO), a specific inhibitor of PTPase.
T10 1120-1272 Sentence denotes The induction of ICAM-1, VCAM-1, and ELAM-1 by TNF in MVEC occurred within 6 h and was also completely down-regulated by PAO in a dose-dependent manner.
T10 1120-1272 Sentence denotes The induction of ICAM-1, VCAM-1, and ELAM-1 by TNF in MVEC occurred within 6 h and was also completely down-regulated by PAO in a dose-dependent manner.
T11 1273-1386 Sentence denotes PAO was found to be effective even when added 3 h after TNF, suggesting a rapid mode of action of this inhibitor.
T11 1273-1386 Sentence denotes PAO was found to be effective even when added 3 h after TNF, suggesting a rapid mode of action of this inhibitor.
T12 1387-1561 Sentence denotes Besides PAO, other inhibitors of PTPase, including pervanadate and diamide, also blocked TNF-dependent NF-kappa B activation and induction of all the three adhesion proteins.
T12 1387-1561 Sentence denotes Besides PAO, other inhibitors of PTPase, including pervanadate and diamide, also blocked TNF-dependent NF-kappa B activation and induction of all the three adhesion proteins.
T13 1562-1671 Sentence denotes Consistent with these results, the attachment of monocytes to MVEC was also blocked by the PTPase inhibitors.
T13 1562-1671 Sentence denotes Consistent with these results, the attachment of monocytes to MVEC was also blocked by the PTPase inhibitors.
T14 1672-1853 Sentence denotes Thus, overall, our results demonstrate that a PTPase is involved either directly or indirectly in the pathway leading to the induction of endothelial cell adhesion molecules by TNF.
T14 1672-1853 Sentence denotes Thus, overall, our results demonstrate that a PTPase is involved either directly or indirectly in the pathway leading to the induction of endothelial cell adhesion molecules by TNF.
T15 1854-2015 Sentence denotes Because of their role in cell adhesion, PTPase may provide a novel target of drug development for treatment of inflammation, atherogenesis, and tumor metastasis.
T15 1854-2015 Sentence denotes Because of their role in cell adhesion, PTPase may provide a novel target of drug development for treatment of inflammation, atherogenesis, and tumor metastasis.