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PubMed:9278334 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-88 Sentence denotes Human monocyte binding to fibronectin enhances IFN-gamma-induced early signaling events.
T1 0-88 Sentence denotes Human monocyte binding to fibronectin enhances IFN-gamma-induced early signaling events.
T2 89-214 Sentence denotes Leukocyte integrins are fundamentally important in modulating adhesion to extracellular matrix components and to other cells.
T2 89-214 Sentence denotes Leukocyte integrins are fundamentally important in modulating adhesion to extracellular matrix components and to other cells.
T3 215-334 Sentence denotes This integrin-mediated adhesion controls leukocyte arrest and extravasation during the onset of inflammatory responses.
T3 215-334 Sentence denotes This integrin-mediated adhesion controls leukocyte arrest and extravasation during the onset of inflammatory responses.
T4 335-478 Sentence denotes Moreover, integrin-ligand interactions trigger signaling pathways that may influence leukocyte phenotype and function at sites of inflammation.
T4 335-478 Sentence denotes Moreover, integrin-ligand interactions trigger signaling pathways that may influence leukocyte phenotype and function at sites of inflammation.
T5 479-613 Sentence denotes In the current studies, we evaluated the combinatorial effects of monocyte adhesion and IFN-gamma on intracellular signaling pathways.
T5 479-613 Sentence denotes In the current studies, we evaluated the combinatorial effects of monocyte adhesion and IFN-gamma on intracellular signaling pathways.
T6 614-865 Sentence denotes IFN-gamma triggers a well-defined signal transduction pathway, which although not directly stimulated by monocyte adherence to fibronectin or arginine-glycine-aspartate (RGD)-coated substrata, was enhanced significantly in these matrix-adherent cells.
T6 614-865 Sentence denotes IFN-gamma triggers a well-defined signal transduction pathway, which although not directly stimulated by monocyte adherence to fibronectin or arginine-glycine-aspartate (RGD)-coated substrata, was enhanced significantly in these matrix-adherent cells.
T7 866-1113 Sentence denotes Compared with monocytes in suspension or adherent on plastic surfaces, monocytes adherent to fibronectin or RGD exhibited a greater than threefold increase in steady state levels of IFN-gamma-induced mRNA for the high affinity Fc gammaRI receptor.
T7 866-1113 Sentence denotes Compared with monocytes in suspension or adherent on plastic surfaces, monocytes adherent to fibronectin or RGD exhibited a greater than threefold increase in steady state levels of IFN-gamma-induced mRNA for the high affinity Fc gammaRI receptor.
T8 1114-1310 Sentence denotes By electrophoretic mobility shift assays, this increase in mRNA was associated with a 5- to 10-fold increase in the STAT1-containing DNA-binding complex that binds to Fc gammaRI promoter elements.
T8 1114-1310 Sentence denotes By electrophoretic mobility shift assays, this increase in mRNA was associated with a 5- to 10-fold increase in the STAT1-containing DNA-binding complex that binds to Fc gammaRI promoter elements.
T9 1311-1482 Sentence denotes Furthermore, the tyrosine phosphorylation of STAT1 and the tyrosine kinases JAK1 and JAK2 was enhanced significantly in RGD-adherent monocytes compared with control cells.
T9 1311-1482 Sentence denotes Furthermore, the tyrosine phosphorylation of STAT1 and the tyrosine kinases JAK1 and JAK2 was enhanced significantly in RGD-adherent monocytes compared with control cells.
T10 1483-1724 Sentence denotes These results suggest a novel mechanism by which integrin-mediated cell adhesion can modulate the magnitude of cytokine-induced signal transduction pathways, thereby amplifying cellular events leading to monocyte activation and inflammation.
T10 1483-1724 Sentence denotes These results suggest a novel mechanism by which integrin-mediated cell adhesion can modulate the magnitude of cytokine-induced signal transduction pathways, thereby amplifying cellular events leading to monocyte activation and inflammation.