> top > projects > Inflammaging > docs > PubMed:9185506 > annotations
Inflammaging  

PubMed:9185506 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-99 Sentence denotes Glucocorticoid-mediated repression of cytokine gene transcription in human arteritis-SCID chimeras.
T1 0-99 Sentence denotes Glucocorticoid-mediated repression of cytokine gene transcription in human arteritis-SCID chimeras.
T2 100-212 Sentence denotes Giant cell arteritis (GCA) is a vasculitic syndrome that preferentially affects medium and large-sized arteries.
T2 100-212 Sentence denotes Giant cell arteritis (GCA) is a vasculitic syndrome that preferentially affects medium and large-sized arteries.
T3 213-364 Sentence denotes Glucocorticoid therapy resolves clinical symptoms within hours to days, but therapy has to be continued over several years to prevent disease relapses.
T3 213-364 Sentence denotes Glucocorticoid therapy resolves clinical symptoms within hours to days, but therapy has to be continued over several years to prevent disease relapses.
T4 365-532 Sentence denotes It is not known whether and how glucocorticoids affect the function of the inflammatory infiltrate or why the disease persists subclinically despite chronic treatment.
T4 365-532 Sentence denotes It is not known whether and how glucocorticoids affect the function of the inflammatory infiltrate or why the disease persists subclinically despite chronic treatment.
T5 533-720 Sentence denotes GCA is self-sustained in temporal arteries engrafted into SCID mice, providing a model in which the mechanisms of action and limitations of glucocorticoid therapy can be examined in vivo.
T5 533-720 Sentence denotes GCA is self-sustained in temporal arteries engrafted into SCID mice, providing a model in which the mechanisms of action and limitations of glucocorticoid therapy can be examined in vivo.
T6 721-1001 Sentence denotes Administration of dexamethasone to temporal artery-SCID chimeras for 1 wk induced a partial suppression of T cell and macrophage function as indicated by the reduced tissue concentrations of IL-2, IL-1beta, and IL-6 mRNA, and by the diminished expression of inducible NO synthase.
T6 721-1001 Sentence denotes Administration of dexamethasone to temporal artery-SCID chimeras for 1 wk induced a partial suppression of T cell and macrophage function as indicated by the reduced tissue concentrations of IL-2, IL-1beta, and IL-6 mRNA, and by the diminished expression of inducible NO synthase.
T7 1002-1115 Sentence denotes In contrast, synthesis of IFN-gamma mRNA was only slightly decreased, and expression of TGF-beta1 was unaffected.
T7 1002-1115 Sentence denotes In contrast, synthesis of IFN-gamma mRNA was only slightly decreased, and expression of TGF-beta1 was unaffected.
T8 1116-1268 Sentence denotes These findings correlated with activation of the IkappaBalpha gene and blockade of the nuclear translocation of NFkappaB in the xenotransplanted tissue.
T8 1116-1268 Sentence denotes These findings correlated with activation of the IkappaBalpha gene and blockade of the nuclear translocation of NFkappaB in the xenotransplanted tissue.
T9 1269-1455 Sentence denotes Dose-response experiments suggested that steroid doses currently used in clinical medicine are suboptimal in repressing NFkappaB-mediated cytokine production in the inflammatory lesions.
T9 1269-1455 Sentence denotes Dose-response experiments suggested that steroid doses currently used in clinical medicine are suboptimal in repressing NFkappaB-mediated cytokine production in the inflammatory lesions.
T10 1456-1626 Sentence denotes Chronic steroid therapy was able to deplete the T cell products IL-2 and IFN-gamma, whereas the activation of tissue-infiltrating macrophages was only partially affected.
T10 1456-1626 Sentence denotes Chronic steroid therapy was able to deplete the T cell products IL-2 and IFN-gamma, whereas the activation of tissue-infiltrating macrophages was only partially affected.
T11 1627-1725 Sentence denotes IL-1beta transcription was abrogated; in contrast, TGF-beta1 mRNA synthesis was steroid resistant.
T11 1627-1725 Sentence denotes IL-1beta transcription was abrogated; in contrast, TGF-beta1 mRNA synthesis was steroid resistant.
T12 1726-1959 Sentence denotes The persistence of TGF-beta1-transcribing macrophages, despite paralysis of T cell function, may provide an explanation for the chronicity of the disease, and may identify a novel therapeutic target in this inflammatory vasculopathy.
T12 1726-1959 Sentence denotes The persistence of TGF-beta1-transcribing macrophages, despite paralysis of T cell function, may provide an explanation for the chronicity of the disease, and may identify a novel therapeutic target in this inflammatory vasculopathy.