| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-122 |
Sentence |
denotes |
CD40 is a functional activation antigen and B7-independent T cell costimulatory molecule on normal human lung fibroblasts. |
| T1 |
0-122 |
Sentence |
denotes |
CD40 is a functional activation antigen and B7-independent T cell costimulatory molecule on normal human lung fibroblasts. |
| T2 |
123-215 |
Sentence |
denotes |
CD40 is an important signaling and activation Ag found on certain bone marrow-derived cells. |
| T2 |
123-215 |
Sentence |
denotes |
CD40 is an important signaling and activation Ag found on certain bone marrow-derived cells. |
| T3 |
216-317 |
Sentence |
denotes |
Recently, CD40 also has been shown to be expressed by mesenchymal cells, including human fibroblasts. |
| T3 |
216-317 |
Sentence |
denotes |
Recently, CD40 also has been shown to be expressed by mesenchymal cells, including human fibroblasts. |
| T4 |
318-372 |
Sentence |
denotes |
Little is known about the role of CD40 in fibroblasts. |
| T4 |
318-372 |
Sentence |
denotes |
Little is known about the role of CD40 in fibroblasts. |
| T5 |
373-539 |
Sentence |
denotes |
The current study investigates the hypothesis that CD40 expressed on lung fibroblasts is an activation structure and mechanism for interaction with hemopoietic cells. |
| T5 |
373-539 |
Sentence |
denotes |
The current study investigates the hypothesis that CD40 expressed on lung fibroblasts is an activation structure and mechanism for interaction with hemopoietic cells. |
| T6 |
540-693 |
Sentence |
denotes |
Communication between resident tissue fibroblasts and T cells is necessary for normal wound healing, and can be pathologic, resulting in tissue fibrosis. |
| T6 |
540-693 |
Sentence |
denotes |
Communication between resident tissue fibroblasts and T cells is necessary for normal wound healing, and can be pathologic, resulting in tissue fibrosis. |
| T7 |
694-914 |
Sentence |
denotes |
Signaling through CD40 with soluble CD40 ligand stimulated fibroblast activation, as evidenced by mobilization of nuclear factor-kappaB and by induction of the proinflammatory and chemoattractant cytokines IL-6 and IL-8. |
| T7 |
694-914 |
Sentence |
denotes |
Signaling through CD40 with soluble CD40 ligand stimulated fibroblast activation, as evidenced by mobilization of nuclear factor-kappaB and by induction of the proinflammatory and chemoattractant cytokines IL-6 and IL-8. |
| T8 |
915-1067 |
Sentence |
denotes |
IFN-gamma-primed lung fibroblasts costimulate T lymphocyte proliferation utilizing CD40, but not the well-studied costimulatory molecules B7-1 and B7-2. |
| T8 |
915-1067 |
Sentence |
denotes |
IFN-gamma-primed lung fibroblasts costimulate T lymphocyte proliferation utilizing CD40, but not the well-studied costimulatory molecules B7-1 and B7-2. |
| T9 |
1068-1305 |
Sentence |
denotes |
Data reported herein support the hypothesis that cognate interactions between tissue fibroblasts and infiltrating T lymphocytes, via the CD40/CD40L pathway, augment inflammation and may promote fibrogenesis by activating both cell types. |
| T9 |
1068-1305 |
Sentence |
denotes |
Data reported herein support the hypothesis that cognate interactions between tissue fibroblasts and infiltrating T lymphocytes, via the CD40/CD40L pathway, augment inflammation and may promote fibrogenesis by activating both cell types. |