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PubMed:9032271 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-104 Sentence denotes Characterization of a mutant cell line that does not activate NF-kappaB in response to multiple stimuli.
T1 0-104 Sentence denotes Characterization of a mutant cell line that does not activate NF-kappaB in response to multiple stimuli.
T2 105-255 Sentence denotes Numerous genes required during the immune or inflammation response as well as the adhesion process are regulated by nuclear factor kappaB (NF-kappaB).
T2 105-255 Sentence denotes Numerous genes required during the immune or inflammation response as well as the adhesion process are regulated by nuclear factor kappaB (NF-kappaB).
T3 256-352 Sentence denotes Associated with its inhibitor, I kappaB, NF-kappaB resides as an inactive form in the cytoplasm.
T3 256-352 Sentence denotes Associated with its inhibitor, I kappaB, NF-kappaB resides as an inactive form in the cytoplasm.
T4 353-492 Sentence denotes Upon stimulation by various agents, I kappaB is proteolyzed and NF-kappaB translocates to the nucleus, where it activates its target genes.
T4 353-492 Sentence denotes Upon stimulation by various agents, I kappaB is proteolyzed and NF-kappaB translocates to the nucleus, where it activates its target genes.
T5 493-579 Sentence denotes The transduction pathways that lead to I kappaB inactivation remain poorly understood.
T5 493-579 Sentence denotes The transduction pathways that lead to I kappaB inactivation remain poorly understood.
T6 580-748 Sentence denotes In this study, we have characterized a cellular mutant, the 70/Z3-derived 1.3E2 murine pre-B cell line, that does not activate NF-kappaB in response to several stimuli.
T6 580-748 Sentence denotes In this study, we have characterized a cellular mutant, the 70/Z3-derived 1.3E2 murine pre-B cell line, that does not activate NF-kappaB in response to several stimuli.
T7 749-988 Sentence denotes We demonstrate that upon stimulation by lipopolysaccharide, Taxol, phorbol myristate acetate, interleukin-1, or double-stranded RNA, I kappaB alpha is not degraded, as a result of an absence of induced phosphorylation on serines 32 and 36.
T7 749-988 Sentence denotes We demonstrate that upon stimulation by lipopolysaccharide, Taxol, phorbol myristate acetate, interleukin-1, or double-stranded RNA, I kappaB alpha is not degraded, as a result of an absence of induced phosphorylation on serines 32 and 36.
T8 989-1153 Sentence denotes Neither a mutation in I kappaB alpha nor a mutation in p50 or relA, the two major subunits of NF-kappaB in this cell line, accounts for this phosphorylation defect.
T8 989-1153 Sentence denotes Neither a mutation in I kappaB alpha nor a mutation in p50 or relA, the two major subunits of NF-kappaB in this cell line, accounts for this phosphorylation defect.
T9 1154-1375 Sentence denotes As well as culminating in the inducible phosphorylation of I kappaB alpha on serines 32 and 36, all the stimuli that are inactive on 1.3E2 cells exhibit a sensitivity to the antioxidant pyrrolidine dithiocarbamate (PDTC).
T9 1154-1375 Sentence denotes As well as culminating in the inducible phosphorylation of I kappaB alpha on serines 32 and 36, all the stimuli that are inactive on 1.3E2 cells exhibit a sensitivity to the antioxidant pyrrolidine dithiocarbamate (PDTC).
T10 1376-1531 Sentence denotes In contrast, stimuli such as hyperosmotic shock or phosphatase inhibitors, which use PDTC-insensitive pathways, induce I kappaB alpha degradation in 1.3E2.
T10 1376-1531 Sentence denotes In contrast, stimuli such as hyperosmotic shock or phosphatase inhibitors, which use PDTC-insensitive pathways, induce I kappaB alpha degradation in 1.3E2.
T11 1532-1622 Sentence denotes Analysis of the redox status of 1.3E2 does not reveal any difference from wild-type 70Z/3.
T11 1532-1622 Sentence denotes Analysis of the redox status of 1.3E2 does not reveal any difference from wild-type 70Z/3.
T12 1623-1834 Sentence denotes We also report that the human T-cell leukemia virus type 1 (HTLV-1)-derived Tax trans-activator induces NF-kappaB activity in 1.3E2, suggesting that this viral protein does not operate via the defective pathway.
T12 1623-1834 Sentence denotes We also report that the human T-cell leukemia virus type 1 (HTLV-1)-derived Tax trans-activator induces NF-kappaB activity in 1.3E2, suggesting that this viral protein does not operate via the defective pathway.
T13 1835-2009 Sentence denotes Finally, we show that two other I kappaB molecules, I kappaB beta and the recently identified I kappaB epsilon, are not degraded in the 1.3E2 cell line following stimulation.
T13 1835-2009 Sentence denotes Finally, we show that two other I kappaB molecules, I kappaB beta and the recently identified I kappaB epsilon, are not degraded in the 1.3E2 cell line following stimulation.
T14 2010-2177 Sentence denotes Our results demonstrate that 1.3E2 is a cellular transduction mutant exhibiting a defect in a step that is required by several different stimuli to activate NF-kappaB.
T14 2010-2177 Sentence denotes Our results demonstrate that 1.3E2 is a cellular transduction mutant exhibiting a defect in a step that is required by several different stimuli to activate NF-kappaB.
T15 2178-2331 Sentence denotes In addition, this analysis suggests a common step in the signaling pathways that trigger I kappaB alpha, I kappaB beta, and I kappaB epsilon degradation.
T15 2178-2331 Sentence denotes In addition, this analysis suggests a common step in the signaling pathways that trigger I kappaB alpha, I kappaB beta, and I kappaB epsilon degradation.