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PubMed:8991511 JSONTXT 70 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-133 Sentence denotes Synthesis of a tetravalent sialyl Lewis x glycan, a high-affinity inhibitor of L-selectin-mediated lymphocyte binding to endothelium.
T1 0-133 Sentence denotes Synthesis of a tetravalent sialyl Lewis x glycan, a high-affinity inhibitor of L-selectin-mediated lymphocyte binding to endothelium.
T2 134-230 Sentence denotes Kidney transplant rejection is an inflammatory process characterized by lymphocyte infiltration.
T2 134-230 Sentence denotes Kidney transplant rejection is an inflammatory process characterized by lymphocyte infiltration.
T3 231-380 Sentence denotes Our earlier observations have shown that peritubular capillary endothelium (PTCE) is the site of lymphocyte entry into the rejecting renal allograft.
T3 231-380 Sentence denotes Our earlier observations have shown that peritubular capillary endothelium (PTCE) is the site of lymphocyte entry into the rejecting renal allograft.
T4 381-515 Sentence denotes During rejection, PTCE begins to express sialyl Lewis x de novo, and binds lymphocytes by a mechanism largely dependent on L-selectin.
T4 381-515 Sentence denotes During rejection, PTCE begins to express sialyl Lewis x de novo, and binds lymphocytes by a mechanism largely dependent on L-selectin.
T5 516-691 Sentence denotes Hence, inhibiting the lymphocyte-endothelial interaction with oligosaccharide ligands of L-selectin offers an attractive possibility to prevent the inflammation and rejection.
T5 516-691 Sentence denotes Hence, inhibiting the lymphocyte-endothelial interaction with oligosaccharide ligands of L-selectin offers an attractive possibility to prevent the inflammation and rejection.
T6 692-945 Sentence denotes Here, we report enzyme-assisted synthesis of N-acetyllactosamine-based tetra-, deca-, and docosameric saccharides carrying one, two or four distally located sialyl Lewis x groups [Neu-NAc alpha 2-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc] (sLex), respectively.
T6 692-945 Sentence denotes Here, we report enzyme-assisted synthesis of N-acetyllactosamine-based tetra-, deca-, and docosameric saccharides carrying one, two or four distally located sialyl Lewis x groups [Neu-NAc alpha 2-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc] (sLex), respectively.
T7 946-1197 Sentence denotes When tested for their ability to inhibit lymphocyte-endothelial interaction during rat kidney transplant rejection, all sLex-saccharides were inhibitors in the Stamper-Woodruff binding assays; the analogues lacking fucose showed no inhibitory potency.
T7 946-1197 Sentence denotes When tested for their ability to inhibit lymphocyte-endothelial interaction during rat kidney transplant rejection, all sLex-saccharides were inhibitors in the Stamper-Woodruff binding assays; the analogues lacking fucose showed no inhibitory potency.
T8 1198-1295 Sentence denotes The tetravalent sLex glycan proved to be a high-affinity adhesion inhibitor with an IC50 < 50 nM.
T8 1198-1295 Sentence denotes The tetravalent sLex glycan proved to be a high-affinity adhesion inhibitor with an IC50 < 50 nM.
T9 1296-1434 Sentence denotes While less powerful than the tetravalent glycan, also the divalent sLex saccharide was a much better inhibitor than the monovalent glycan.
T9 1296-1434 Sentence denotes While less powerful than the tetravalent glycan, also the divalent sLex saccharide was a much better inhibitor than the monovalent glycan.
T10 1435-1639 Sentence denotes Hence, increasing multivalency and, possibly, increasing chain length of the polylactosamine backbone, enhances the inhibitory potency of sLex bearing glycans in the lymphocyte-endothelial adhesion assay.
T10 1435-1639 Sentence denotes Hence, increasing multivalency and, possibly, increasing chain length of the polylactosamine backbone, enhances the inhibitory potency of sLex bearing glycans in the lymphocyte-endothelial adhesion assay.
T11 1640-1728 Sentence denotes This suggests that L-selectin behaves as a "functional oligomer" on lymphocyte surfaces.
T11 1640-1728 Sentence denotes This suggests that L-selectin behaves as a "functional oligomer" on lymphocyte surfaces.