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PubMed:8978306 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-72 Sentence denotes Engagement of the Lewis X antigen (CD15) results in monocyte activation.
T1 0-72 Sentence denotes Engagement of the Lewis X antigen (CD15) results in monocyte activation.
T2 73-248 Sentence denotes We previously reported that monocyte adhesion to tumor necrosis factor-alpha (TNF-alpha)-treated endothelial cells increased expression of tissue factor and CD36 on monocytes.
T2 73-248 Sentence denotes We previously reported that monocyte adhesion to tumor necrosis factor-alpha (TNF-alpha)-treated endothelial cells increased expression of tissue factor and CD36 on monocytes.
T3 249-452 Sentence denotes Using immunological cross-linking to mimic receptor engagement by natural ligands, we now show that CD15 (Lewis X), a monocyte counter-receptor for endothelial selectins may participate in this response.
T3 249-452 Sentence denotes Using immunological cross-linking to mimic receptor engagement by natural ligands, we now show that CD15 (Lewis X), a monocyte counter-receptor for endothelial selectins may participate in this response.
T4 453-653 Sentence denotes We used cytokine production as a readout for monocyte activation and found that CD15 cross-linking induced TNF-alpha release from peripheral blood monocytes and cells from the monocytic cell line MM6.
T4 453-653 Sentence denotes We used cytokine production as a readout for monocyte activation and found that CD15 cross-linking induced TNF-alpha release from peripheral blood monocytes and cells from the monocytic cell line MM6.
T5 654-810 Sentence denotes Quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) showed an increase in steady-state TNF-alpha mRNA after 3 to 4 hours of cross-linking.
T5 654-810 Sentence denotes Quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) showed an increase in steady-state TNF-alpha mRNA after 3 to 4 hours of cross-linking.
T6 811-991 Sentence denotes CD15 cross-linking also concomitantly increased interleukin-1 beta (IL-1 beta) mRNA, while no apparent change was observed in the levels of beta-actin mRNA, indicating specificity.
T6 811-991 Sentence denotes CD15 cross-linking also concomitantly increased interleukin-1 beta (IL-1 beta) mRNA, while no apparent change was observed in the levels of beta-actin mRNA, indicating specificity.
T7 992-1174 Sentence denotes To examine transcriptional regulation of cytokine genes by CD15 engagement, a CAT plasmid reporter construct containing IL-1 beta promoter/enhancer sequences was introduced into MM6.
T7 992-1174 Sentence denotes To examine transcriptional regulation of cytokine genes by CD15 engagement, a CAT plasmid reporter construct containing IL-1 beta promoter/enhancer sequences was introduced into MM6.
T8 1175-1231 Sentence denotes Subsequent cross-linking of CD15 increased CAT activity.
T8 1175-1231 Sentence denotes Subsequent cross-linking of CD15 increased CAT activity.
T9 1232-1396 Sentence denotes CD15 engagement by monoclonal antibody also attenuated IL-1 beta transcript degradation, demonstrating that signaling via CD15 also had posttranscriptional effects.
T9 1232-1396 Sentence denotes CD15 engagement by monoclonal antibody also attenuated IL-1 beta transcript degradation, demonstrating that signaling via CD15 also had posttranscriptional effects.
T10 1397-1620 Sentence denotes Nuclear extracts of anti-CD15 cross-linked cells demonstrated enhanced levels of the transcriptional factor activator protein-1, minimally changed nuclear factor-kappa B, and did not affect SV40 promoter specific protein-1.
T10 1397-1620 Sentence denotes Nuclear extracts of anti-CD15 cross-linked cells demonstrated enhanced levels of the transcriptional factor activator protein-1, minimally changed nuclear factor-kappa B, and did not affect SV40 promoter specific protein-1.
T11 1621-1701 Sentence denotes We conclude that engagement of CD15 on monocytes results in monocyte activation.
T11 1621-1701 Sentence denotes We conclude that engagement of CD15 on monocytes results in monocyte activation.
T12 1702-1913 Sentence denotes In addition to its well-recognized adhesive role, CD15 may function as an important signaling molecule capable of initiating proinflammatory events in monocytes that come into contact with activated endothelium.
T12 1702-1913 Sentence denotes In addition to its well-recognized adhesive role, CD15 may function as an important signaling molecule capable of initiating proinflammatory events in monocytes that come into contact with activated endothelium.