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PubMed:8977508 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T1 0-116 Sentence denotes Effects of glucocorticoids on lymphocyte activation in patients with steroid-sensitive and steroid-resistant asthma.
T1 0-116 Sentence denotes Effects of glucocorticoids on lymphocyte activation in patients with steroid-sensitive and steroid-resistant asthma.
T2 117-128 Sentence denotes BACKGROUND:
T2 117-128 Sentence denotes BACKGROUND:
T3 129-234 Sentence denotes Glucocorticoids are important medications used to control the airway inflammation associated with asthma.
T3 129-234 Sentence denotes Glucocorticoids are important medications used to control the airway inflammation associated with asthma.
T4 235-330 Sentence denotes Synthetic glucocorticoids vary in their binding affinity for the glucocorticoid receptor (GCR).
T4 235-330 Sentence denotes Synthetic glucocorticoids vary in their binding affinity for the glucocorticoid receptor (GCR).
T5 331-339 Sentence denotes METHODS:
T5 331-339 Sentence denotes METHODS:
T6 340-663 Sentence denotes We compared hydrocortisone, beclomethasone dipropionate, triamcinolone acetonide, flunisolide, and budesonide with regard to their capacity to inhibit phytohemagglutinin-induced peripheral blood mononuclear cell proliferation from six patients with steroid-sensitive asthma and seven patients with steroid-resistant asthma.
T6 340-663 Sentence denotes We compared hydrocortisone, beclomethasone dipropionate, triamcinolone acetonide, flunisolide, and budesonide with regard to their capacity to inhibit phytohemagglutinin-induced peripheral blood mononuclear cell proliferation from six patients with steroid-sensitive asthma and seven patients with steroid-resistant asthma.
T7 664-859 Sentence denotes Peripheral blood mononuclear cell GCR binding affinities for dexamethasone and budesonide were also determined for both patient groups by using a radioligand binding assay and Scatchard analysis.
T7 664-859 Sentence denotes Peripheral blood mononuclear cell GCR binding affinities for dexamethasone and budesonide were also determined for both patient groups by using a radioligand binding assay and Scatchard analysis.
T8 860-868 Sentence denotes RESULTS:
T8 860-868 Sentence denotes RESULTS:
T9 869-1088 Sentence denotes Dose-dependent inhibition was demonstrated for all glucocorticoids in both patient groups, with the steroid-resistant group requiring approximately 2 log-fold more glucocorticoids for an equivalent degree of inhibition.
T9 869-1088 Sentence denotes Dose-dependent inhibition was demonstrated for all glucocorticoids in both patient groups, with the steroid-resistant group requiring approximately 2 log-fold more glucocorticoids for an equivalent degree of inhibition.
T10 1089-1461 Sentence denotes The mean concentrations necessary to cause 50% inhibition of lymphocyte proliferation (IC50s) for the steroid-sensitive group ranged from 2 x 10(-10) mol/L for budesonide to 7 x 10(-8) mol/L for hydrocortisone, whereas the mean IC50s for the steroid-resistant group ranged from approximately 2 x 10(-8) mol/L for budesonide to greater than 10(-6) mol/L for hydrocortisone.
T10 1089-1461 Sentence denotes The mean concentrations necessary to cause 50% inhibition of lymphocyte proliferation (IC50s) for the steroid-sensitive group ranged from 2 x 10(-10) mol/L for budesonide to 7 x 10(-8) mol/L for hydrocortisone, whereas the mean IC50s for the steroid-resistant group ranged from approximately 2 x 10(-8) mol/L for budesonide to greater than 10(-6) mol/L for hydrocortisone.
T11 1462-1632 Sentence denotes In addition, a significant correlation was noted between the degree of inhibition of lymphocyte proliferation (IC50) and the binding affinity of dexamethasone to the GCR.
T11 1462-1632 Sentence denotes In addition, a significant correlation was noted between the degree of inhibition of lymphocyte proliferation (IC50) and the binding affinity of dexamethasone to the GCR.
T12 1633-1727 Sentence denotes Patients with steroid-resistant asthma have been shown to have a reduced GCR binding affinity.
T12 1633-1727 Sentence denotes Patients with steroid-resistant asthma have been shown to have a reduced GCR binding affinity.
T13 1728-1881 Sentence denotes The GCR binding affinity for budesonide was significantly higher in both groups (i.e., lower dissociation constant) than that obtained for dexamethasone.
T13 1728-1881 Sentence denotes The GCR binding affinity for budesonide was significantly higher in both groups (i.e., lower dissociation constant) than that obtained for dexamethasone.
T14 1882-1893 Sentence denotes CONCLUSION:
T14 1882-1893 Sentence denotes CONCLUSION:
T15 1894-2136 Sentence denotes These data suggest that glucocorticoids such as budesonide, by virtue of their high GCR binding affinities and greater ability to suppress lymphocyte proliferation, may therefore be beneficial in the management of difficult-to-control asthma.
T15 1894-2136 Sentence denotes These data suggest that glucocorticoids such as budesonide, by virtue of their high GCR binding affinities and greater ability to suppress lymphocyte proliferation, may therefore be beneficial in the management of difficult-to-control asthma.