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PubMed:8955212 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-115 Sentence denotes Induction of the CD11b gene during activation of the monocytic cell line U937 requires a novel nuclear factor MS-2.
T1 0-115 Sentence denotes Induction of the CD11b gene during activation of the monocytic cell line U937 requires a novel nuclear factor MS-2.
T2 116-271 Sentence denotes The differentiation of myeloid precursors into mature myelomonocytic cells is characterized by the induction of the gene encoding the beta2 integrin CD11b.
T2 116-271 Sentence denotes The differentiation of myeloid precursors into mature myelomonocytic cells is characterized by the induction of the gene encoding the beta2 integrin CD11b.
T3 272-420 Sentence denotes The transcription factors Sp1 and PU.1 prime the CD11b promoter, but the nature of the factors responsible for its inducible expression are unknown.
T3 272-420 Sentence denotes The transcription factors Sp1 and PU.1 prime the CD11b promoter, but the nature of the factors responsible for its inducible expression are unknown.
T4 421-563 Sentence denotes In addition to the CD11b gene, the homologous genes encoding CD11a and CD11c also exhibit inducible expression during myeloid differentiation.
T4 421-563 Sentence denotes In addition to the CD11b gene, the homologous genes encoding CD11a and CD11c also exhibit inducible expression during myeloid differentiation.
T5 564-732 Sentence denotes Therefore, we compared the nucleotide sequences of the CD11a, CD11b, and CD11c gene promoters to identify common elements that might contribute to inducible expression.
T5 564-732 Sentence denotes Therefore, we compared the nucleotide sequences of the CD11a, CD11b, and CD11c gene promoters to identify common elements that might contribute to inducible expression.
T6 733-821 Sentence denotes This analysis identified one such element repeated four times within the CD11b promoter.
T6 733-821 Sentence denotes This analysis identified one such element repeated four times within the CD11b promoter.
T7 822-1000 Sentence denotes Mutation of these elements indicated that two, MS-2beta and MS-2gamma, are critical to the induction of the CD11b gene during differentiation of the pro-monocytic cell line U937.
T7 822-1000 Sentence denotes Mutation of these elements indicated that two, MS-2beta and MS-2gamma, are critical to the induction of the CD11b gene during differentiation of the pro-monocytic cell line U937.
T8 1001-1151 Sentence denotes Electrophoretic mobility shift assays indicate that MS-2beta and MS-2gamma interact with nuclear factors that are induced during U937 differentiation.
T8 1001-1151 Sentence denotes Electrophoretic mobility shift assays indicate that MS-2beta and MS-2gamma interact with nuclear factors that are induced during U937 differentiation.
T9 1152-1223 Sentence denotes These factors are detected at the time the CD11b promoter is activated.
T9 1152-1223 Sentence denotes These factors are detected at the time the CD11b promoter is activated.
T10 1224-1389 Sentence denotes The molecular mass of these factors is approximately 28 kDa, and their DNA binding characteristics are indistinguishable from those of the novel nuclear factor MS-2.
T10 1224-1389 Sentence denotes The molecular mass of these factors is approximately 28 kDa, and their DNA binding characteristics are indistinguishable from those of the novel nuclear factor MS-2.
T11 1390-1512 Sentence denotes Taken together, our data indicate that MS-2 mediates induction of the CD11b gene as cells of the monocytic lineage mature.
T11 1390-1512 Sentence denotes Taken together, our data indicate that MS-2 mediates induction of the CD11b gene as cells of the monocytic lineage mature.
T12 1513-1723 Sentence denotes The presence of multiple potential binding sites for MS-2 in the promoter regions of a wide range of genes expressed in mature myeloid cells suggests this factor plays a general role in myeloid differentiation.
T12 1513-1723 Sentence denotes The presence of multiple potential binding sites for MS-2 in the promoter regions of a wide range of genes expressed in mature myeloid cells suggests this factor plays a general role in myeloid differentiation.