Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-129 |
Sentence |
denotes |
Reduction of rat myocardial ischemia and reperfusion injury by sialyl Lewis x oligosaccharide and anti-rat P-selectin antibodies. |
T1 |
0-129 |
Sentence |
denotes |
Reduction of rat myocardial ischemia and reperfusion injury by sialyl Lewis x oligosaccharide and anti-rat P-selectin antibodies. |
T2 |
130-232 |
Sentence |
denotes |
Polymorphonuclear leukocytes (PMN) are directly involved in development of ischemic myocardial injury. |
T2 |
130-232 |
Sentence |
denotes |
Polymorphonuclear leukocytes (PMN) are directly involved in development of ischemic myocardial injury. |
T3 |
233-364 |
Sentence |
denotes |
Adhesion of PMN to endothelial cells is an initial step that triggers a sequential process leading to acute inflammatory responses. |
T3 |
233-364 |
Sentence |
denotes |
Adhesion of PMN to endothelial cells is an initial step that triggers a sequential process leading to acute inflammatory responses. |
T4 |
365-510 |
Sentence |
denotes |
Interaction between P-selectin and its oligosaccharide ligand, sialyl Lewis x (sLex), plays an important role in the early stage of the adhesion. |
T4 |
365-510 |
Sentence |
denotes |
Interaction between P-selectin and its oligosaccharide ligand, sialyl Lewis x (sLex), plays an important role in the early stage of the adhesion. |
T5 |
511-707 |
Sentence |
denotes |
To examine the role of P-selectin in various animal disease models especially in rats, we have cloned rat E- and P-selectin cDNAs and established monoclonal antibodies against these rat selectins. |
T5 |
511-707 |
Sentence |
denotes |
To examine the role of P-selectin in various animal disease models especially in rats, we have cloned rat E- and P-selectin cDNAs and established monoclonal antibodies against these rat selectins. |
T6 |
708-813 |
Sentence |
denotes |
In this report, we describe the generation and characterization of anti-rat P-selectin antibodies (ARPs). |
T6 |
708-813 |
Sentence |
denotes |
In this report, we describe the generation and characterization of anti-rat P-selectin antibodies (ARPs). |
T7 |
814-899 |
Sentence |
denotes |
These antibodies detect cell surface P-selectin on thrombin-stimulated rat platelets. |
T7 |
814-899 |
Sentence |
denotes |
These antibodies detect cell surface P-selectin on thrombin-stimulated rat platelets. |
T8 |
900-1074 |
Sentence |
denotes |
More importantly, intravenous administration of ARP2-4 reduced infarction developed after 30 min of ischemia followed by 24 h of reperfusion in a rat myocardial injury model. |
T8 |
900-1074 |
Sentence |
denotes |
More importantly, intravenous administration of ARP2-4 reduced infarction developed after 30 min of ischemia followed by 24 h of reperfusion in a rat myocardial injury model. |
T9 |
1075-1176 |
Sentence |
denotes |
In addition, similar protective effect was also observed by administration of a sLex-oligosaccharide. |
T9 |
1075-1176 |
Sentence |
denotes |
In addition, similar protective effect was also observed by administration of a sLex-oligosaccharide. |
T10 |
1177-1322 |
Sentence |
denotes |
These results indicate that cell adhesion mediated via P-selectin is involved in the development of ischemia and reperfusion injury in rat heart. |
T10 |
1177-1322 |
Sentence |
denotes |
These results indicate that cell adhesion mediated via P-selectin is involved in the development of ischemia and reperfusion injury in rat heart. |