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PubMed:8646681 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T1 0-62 Sentence denotes Extensive apoptosis in ductal carcinoma in situ of the breast.
T1 0-62 Sentence denotes Extensive apoptosis in ductal carcinoma in situ of the breast.
T2 63-74 Sentence denotes BACKGROUND:
T2 63-74 Sentence denotes BACKGROUND:
T3 75-273 Sentence denotes More than 50% of breast ductal carcinomas in situ (DCIS) contain significant histologic necrosis, an important prognostic factor for determining recurrence and progression to invasive breast cancer.
T3 75-273 Sentence denotes More than 50% of breast ductal carcinomas in situ (DCIS) contain significant histologic necrosis, an important prognostic factor for determining recurrence and progression to invasive breast cancer.
T4 274-484 Sentence denotes We have examined whether the mechanism of this spontaneous cell death might be apoptosis, a genetically encoded suicide pathway that may be triggered by various events including dysregulated cell proliferation.
T4 274-484 Sentence denotes We have examined whether the mechanism of this spontaneous cell death might be apoptosis, a genetically encoded suicide pathway that may be triggered by various events including dysregulated cell proliferation.
T5 485-493 Sentence denotes METHODS:
T5 485-493 Sentence denotes METHODS:
T6 494-893 Sentence denotes Twenty-five untreated DCIS cases accessioned at our institution were examined for subtype, grade, and presence of apoptosis using two criteria: (1) cellular morphology (shrinkage, nuclear condensation, fragmentation, apoptotic bodies, and lack of inflammatory component); and (2) terminal transferase (TUNEL) staining of DNA fragmentation, a characteristic though less specific feature of apoptosis.
T6 494-893 Sentence denotes Twenty-five untreated DCIS cases accessioned at our institution were examined for subtype, grade, and presence of apoptosis using two criteria: (1) cellular morphology (shrinkage, nuclear condensation, fragmentation, apoptotic bodies, and lack of inflammatory component); and (2) terminal transferase (TUNEL) staining of DNA fragmentation, a characteristic though less specific feature of apoptosis.
T7 894-1039 Sentence denotes Immunohistochemical staining was also carried out to assess whether wild-type p53, a regulator of apoptosis, was associated with this cell death.
T7 894-1039 Sentence denotes Immunohistochemical staining was also carried out to assess whether wild-type p53, a regulator of apoptosis, was associated with this cell death.
T8 1040-1048 Sentence denotes RESULTS:
T8 1040-1048 Sentence denotes RESULTS:
T9 1049-1279 Sentence denotes In all 19 cases with intraductal necrosis, cellular morphology was consistent with apoptotic death, despite its presence within sheets of "geographic necrosis." Additionally, the identical regions were all strongly TUNEL-positive.
T9 1049-1279 Sentence denotes In all 19 cases with intraductal necrosis, cellular morphology was consistent with apoptotic death, despite its presence within sheets of "geographic necrosis." Additionally, the identical regions were all strongly TUNEL-positive.
T10 1280-1372 Sentence denotes No evidence of TUNEL staining was seen in 5 Grade I DCIS cases without intraductal necrosis.
T10 1280-1372 Sentence denotes No evidence of TUNEL staining was seen in 5 Grade I DCIS cases without intraductal necrosis.
T11 1373-1473 Sentence denotes Immunohistochemical staining suggested that this apoptosis was independent of p53 mutational status.
T11 1373-1473 Sentence denotes Immunohistochemical staining suggested that this apoptosis was independent of p53 mutational status.
T12 1474-1486 Sentence denotes CONCLUSIONS:
T12 1474-1486 Sentence denotes CONCLUSIONS:
T13 1487-1559 Sentence denotes Extensive intraductal necrosis in DCIS is likely to represent apoptosis.
T13 1487-1559 Sentence denotes Extensive intraductal necrosis in DCIS is likely to represent apoptosis.
T14 1560-1624 Sentence denotes However, it is unlikely that this apoptosis is regulated by p53.
T14 1560-1624 Sentence denotes However, it is unlikely that this apoptosis is regulated by p53.
T15 1625-1812 Sentence denotes The apparently abundant apoptosis identified here, particularly in high grade DCIS, may be important in explaining why spontaneous cell death in DCIS is associated with a worse prognosis.
T15 1625-1812 Sentence denotes The apparently abundant apoptosis identified here, particularly in high grade DCIS, may be important in explaining why spontaneous cell death in DCIS is associated with a worse prognosis.