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PubMed:8632999 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-101 Sentence denotes CNI-1493 inhibits monocyte/macrophage tumor necrosis factor by suppression of translation efficiency.
T1 0-101 Sentence denotes CNI-1493 inhibits monocyte/macrophage tumor necrosis factor by suppression of translation efficiency.
T2 102-241 Sentence denotes Tumor necrosis factor (TNF) mediates a wide variety of disease states including septic shock, acute and chronic inflammation, and cachexia.
T2 102-241 Sentence denotes Tumor necrosis factor (TNF) mediates a wide variety of disease states including septic shock, acute and chronic inflammation, and cachexia.
T3 242-510 Sentence denotes Recently, a multivalent guanylhydrazone (CNI-1493) developed as an inhibitor of macrophage activation was shown to suppress TNF production and protect against tissue inflammation and endotoxin lethality [Bianchi, M., Ulrich, P., Bloom, O., Meistrell, M., Zimmerman, G.
T3 242-510 Sentence denotes Recently, a multivalent guanylhydrazone (CNI-1493) developed as an inhibitor of macrophage activation was shown to suppress TNF production and protect against tissue inflammation and endotoxin lethality [Bianchi, M., Ulrich, P., Bloom, O., Meistrell, M., Zimmerman, G.
T4 511-601 Sentence denotes A., Schmidtmayerova, H., Bukrinsky, M., Donnelley, T., Bucala, R., Sherry, B., Manogue, K.
T4 511-601 Sentence denotes A., Schmidtmayerova, H., Bukrinsky, M., Donnelley, T., Bucala, R., Sherry, B., Manogue, K.
T5 602-619 Sentence denotes R., Tortolani, A.
T5 602-619 Sentence denotes R., Tortolani, A.
T6 620-647 Sentence denotes J., Cerami, A. & Tracey, K.
T6 620-647 Sentence denotes J., Cerami, A. & Tracey, K.
T7 648-662 Sentence denotes J. (1995) Mol.
T7 648-662 Sentence denotes J. (1995) Mol.
T8 663-667 Sentence denotes Med.
T8 663-667 Sentence denotes Med.
T9 668-728 Sentence denotes 1, 254-266, and Bianchi, M., Bloom, O., Raabe, T., Cohen, P.
T9 668-728 Sentence denotes 1, 254-266, and Bianchi, M., Bloom, O., Raabe, T., Cohen, P.
T10 729-850 Sentence denotes S., Chesney, J., Sherry, B., Schmidtmayerova, H., Zhang, X., Bukrinsky, M., Ulrich, P., Cerami, A. & Tracey, J. (1996) J.
T10 729-850 Sentence denotes S., Chesney, J., Sherry, B., Schmidtmayerova, H., Zhang, X., Bukrinsky, M., Ulrich, P., Cerami, A. & Tracey, J. (1996) J.
T11 851-855 Sentence denotes Exp.
T11 851-855 Sentence denotes Exp.
T12 856-872 Sentence denotes Med., in press].
T12 856-872 Sentence denotes Med., in press].
T13 873-1039 Sentence denotes We have now elucidated the mechanism by which CNI-1493 inhibits macrophage TNF synthesis and show here that it acts through suppression of TNF translation efficiency.
T13 873-1039 Sentence denotes We have now elucidated the mechanism by which CNI-1493 inhibits macrophage TNF synthesis and show here that it acts through suppression of TNF translation efficiency.
T14 1040-1372 Sentence denotes CNI-1493 blocked neither the lipopolysaccharide (LPS)-induced increases in the expression of TNF mRNA nor the translocation of nuclear factor NF-kappa B to the nucleus in macrophages activated by 15 min of LPS stimulation, indicating that CNI-1493 does not interfere with early NF-kappa B-mediated transcriptional regulation of TNF.
T14 1040-1372 Sentence denotes CNI-1493 blocked neither the lipopolysaccharide (LPS)-induced increases in the expression of TNF mRNA nor the translocation of nuclear factor NF-kappa B to the nucleus in macrophages activated by 15 min of LPS stimulation, indicating that CNI-1493 does not interfere with early NF-kappa B-mediated transcriptional regulation of TNF.
T15 1373-1463 Sentence denotes However, synthesis of the 26-kDa membrane form of TNF was effectively blocked by CNI-1493.
T15 1373-1463 Sentence denotes However, synthesis of the 26-kDa membrane form of TNF was effectively blocked by CNI-1493.
T16 1464-1690 Sentence denotes Further evidence for the translational suppression of TNF is given by experiments using chloram-phenicol acetyltransferase (CAT) constructs containing elements of the TNF gene that are involved in TNF translational regulation.
T16 1464-1690 Sentence denotes Further evidence for the translational suppression of TNF is given by experiments using chloram-phenicol acetyltransferase (CAT) constructs containing elements of the TNF gene that are involved in TNF translational regulation.
T17 1691-1817 Sentence denotes Both the 5' and 3' untranslated regions of the TNF gene were required to elicit maximal translational suppression by CNI-1493.
T17 1691-1817 Sentence denotes Both the 5' and 3' untranslated regions of the TNF gene were required to elicit maximal translational suppression by CNI-1493.
T18 1818-2004 Sentence denotes Identification of the molecular target through which CNI-1493 inhibits TNF translation should provide insight into the regulation of macrophage activation and mechanisms of inflammation.
T18 1818-2004 Sentence denotes Identification of the molecular target through which CNI-1493 inhibits TNF translation should provide insight into the regulation of macrophage activation and mechanisms of inflammation.