| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-120 |
Sentence |
denotes |
Physiological concentration of estradiol inhibits polymorphonuclear leukocyte chemotaxis via a receptor mediated system. |
| T1 |
0-120 |
Sentence |
denotes |
Physiological concentration of estradiol inhibits polymorphonuclear leukocyte chemotaxis via a receptor mediated system. |
| T2 |
121-219 |
Sentence |
denotes |
Estrogen exhibits a variety of actions, including immuno-modulatory effects, in vivo and in vitro. |
| T2 |
121-219 |
Sentence |
denotes |
Estrogen exhibits a variety of actions, including immuno-modulatory effects, in vivo and in vitro. |
| T3 |
220-310 |
Sentence |
denotes |
The mechanism by which estrogen exerts its anti-inflammatory effect is not yet understood. |
| T3 |
220-310 |
Sentence |
denotes |
The mechanism by which estrogen exerts its anti-inflammatory effect is not yet understood. |
| T4 |
311-459 |
Sentence |
denotes |
We investigated the possible mechanisms of estradiol acting via the polymorphonuclear leukocytes (PMNs), which are important in the immune response. |
| T4 |
311-459 |
Sentence |
denotes |
We investigated the possible mechanisms of estradiol acting via the polymorphonuclear leukocytes (PMNs), which are important in the immune response. |
| T5 |
460-638 |
Sentence |
denotes |
The agent, 17 beta-estradiol, but not 17 alpha-estradiol, significantly reduced PMNs chemotaxis to FMLP in a dose-dependent manner (control vs estrogen 10(-10)-(-6) M, P < 0.05). |
| T5 |
460-638 |
Sentence |
denotes |
The agent, 17 beta-estradiol, but not 17 alpha-estradiol, significantly reduced PMNs chemotaxis to FMLP in a dose-dependent manner (control vs estrogen 10(-10)-(-6) M, P < 0.05). |
| T6 |
639-740 |
Sentence |
denotes |
Physiological concentrations of estradiol significantly reduced the chemotaxis of PMNs (10(-10) mol). |
| T6 |
639-740 |
Sentence |
denotes |
Physiological concentrations of estradiol significantly reduced the chemotaxis of PMNs (10(-10) mol). |
| T7 |
741-941 |
Sentence |
denotes |
Pre-incubation with clomiphene or tamoxifen which are estrogen receptor antagonists, eliminated the inhibitory effect of 17 beta-estradiol on the chemotaxis of PMNs, restoring it to the control level. |
| T7 |
741-941 |
Sentence |
denotes |
Pre-incubation with clomiphene or tamoxifen which are estrogen receptor antagonists, eliminated the inhibitory effect of 17 beta-estradiol on the chemotaxis of PMNs, restoring it to the control level. |
| T8 |
942-1060 |
Sentence |
denotes |
These observations suggest that 17 beta-estradiol suppressed the chemotaxis of PMNs by a receptor-dependent mechanism. |
| T8 |
942-1060 |
Sentence |
denotes |
These observations suggest that 17 beta-estradiol suppressed the chemotaxis of PMNs by a receptor-dependent mechanism. |
| T9 |
1061-1229 |
Sentence |
denotes |
In addition, the level of estradiol in human plasma, which PMNs were drawn, showed a close, inverse correlation with the PMNs chemotaxis to FMLP (r = -0.821 p < 0.001). |
| T9 |
1061-1229 |
Sentence |
denotes |
In addition, the level of estradiol in human plasma, which PMNs were drawn, showed a close, inverse correlation with the PMNs chemotaxis to FMLP (r = -0.821 p < 0.001). |
| T10 |
1230-1367 |
Sentence |
denotes |
Estrogen may modify the activity of neutrophils during the normal menstrual cycle, not only during pregnancy, and influence inflammation. |
| T10 |
1230-1367 |
Sentence |
denotes |
Estrogen may modify the activity of neutrophils during the normal menstrual cycle, not only during pregnancy, and influence inflammation. |