| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-136 |
Sentence |
denotes |
Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factors. |
| T1 |
0-136 |
Sentence |
denotes |
Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factors. |
| T2 |
137-371 |
Sentence |
denotes |
CD4+ macrophages in tissues such as lung, skin, and lymph nodes, promyelocytic cells in bone marrow, and peripheral blood monocytes serve as important targets and reservoirs for human immunodeficiency virus type 1 (HIV-1) replication. |
| T2 |
137-371 |
Sentence |
denotes |
CD4+ macrophages in tissues such as lung, skin, and lymph nodes, promyelocytic cells in bone marrow, and peripheral blood monocytes serve as important targets and reservoirs for human immunodeficiency virus type 1 (HIV-1) replication. |
| T3 |
372-509 |
Sentence |
denotes |
HIV-1-infected myeloid cells are often diminished in their ability to participate in chemotaxis, phagocytosis, and intracellular killing. |
| T3 |
372-509 |
Sentence |
denotes |
HIV-1-infected myeloid cells are often diminished in their ability to participate in chemotaxis, phagocytosis, and intracellular killing. |
| T4 |
510-783 |
Sentence |
denotes |
HIV-1 infection of myeloid cells can lead to the expression of surface receptors associated with cellular activation and/or differentiation that increase the responsiveness of these cells to cytokines secreted by neighboring cells as well as to bacteria or other pathogens. |
| T4 |
510-783 |
Sentence |
denotes |
HIV-1 infection of myeloid cells can lead to the expression of surface receptors associated with cellular activation and/or differentiation that increase the responsiveness of these cells to cytokines secreted by neighboring cells as well as to bacteria or other pathogens. |
| T5 |
784-923 |
Sentence |
denotes |
Enhancement of HIV-1 replication is related in part to increased DNA-binding activity of cellular transcription factors such as NF-kappa B. |
| T5 |
784-923 |
Sentence |
denotes |
Enhancement of HIV-1 replication is related in part to increased DNA-binding activity of cellular transcription factors such as NF-kappa B. |
| T6 |
924-1101 |
Sentence |
denotes |
NF-kappa B binds to the HIV-1 enhancer region of the long terminal repeat and contributes to the inducibility of HIV-1 gene expression in response to multiple activating agents. |
| T6 |
924-1101 |
Sentence |
denotes |
NF-kappa B binds to the HIV-1 enhancer region of the long terminal repeat and contributes to the inducibility of HIV-1 gene expression in response to multiple activating agents. |
| T7 |
1102-1262 |
Sentence |
denotes |
Phosphorylation and degradation of the cytoplasmic inhibitor I kappa B alpha are crucial regulatory events in the activation of NF-kappa B DNA-binding activity. |
| T7 |
1102-1262 |
Sentence |
denotes |
Phosphorylation and degradation of the cytoplasmic inhibitor I kappa B alpha are crucial regulatory events in the activation of NF-kappa B DNA-binding activity. |
| T8 |
1263-1360 |
Sentence |
denotes |
Both N- and C-terminal residues of I kappa B alpha are required for inducer-mediated degradation. |
| T8 |
1263-1360 |
Sentence |
denotes |
Both N- and C-terminal residues of I kappa B alpha are required for inducer-mediated degradation. |
| T9 |
1361-1539 |
Sentence |
denotes |
Chronic HIV-1 infection of myeloid cells leads to constitutive NF-kappa B DNA-binding activity and provides an intranuclear environment capable of perpetuating HIV-1 replication. |
| T9 |
1361-1539 |
Sentence |
denotes |
Chronic HIV-1 infection of myeloid cells leads to constitutive NF-kappa B DNA-binding activity and provides an intranuclear environment capable of perpetuating HIV-1 replication. |
| T10 |
1540-1679 |
Sentence |
denotes |
Increased intracellular stores of latent NF-kappa B may also result in rapid inducibility of NF-kappa B-dependent cytokine gene expression. |
| T10 |
1540-1679 |
Sentence |
denotes |
Increased intracellular stores of latent NF-kappa B may also result in rapid inducibility of NF-kappa B-dependent cytokine gene expression. |
| T11 |
1680-1906 |
Sentence |
denotes |
In response to secondary pathogenic infections or antigenic challenge, cytokine gene expression is rapidly induced, enhanced, and sustained over prolonged periods in HIV-1-infected myeloid cells compared with uninfected cells. |
| T11 |
1680-1906 |
Sentence |
denotes |
In response to secondary pathogenic infections or antigenic challenge, cytokine gene expression is rapidly induced, enhanced, and sustained over prolonged periods in HIV-1-infected myeloid cells compared with uninfected cells. |
| T12 |
1907-2018 |
Sentence |
denotes |
Elevated levels of several inflammatory cytokines have been detected in the sera of HIV-1-infected individuals. |
| T12 |
1907-2018 |
Sentence |
denotes |
Elevated levels of several inflammatory cytokines have been detected in the sera of HIV-1-infected individuals. |
| T13 |
2019-2142 |
Sentence |
denotes |
Secretion of myeloid cell-derived cytokines may both increase virus production and contribute to AIDS-associated disorders. |
| T13 |
2019-2142 |
Sentence |
denotes |
Secretion of myeloid cell-derived cytokines may both increase virus production and contribute to AIDS-associated disorders. |