> top > projects > Inflammaging > docs > PubMed:7541794 > annotations
Inflammaging  

PubMed:7541794 JSONTXT 31 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-93 Sentence denotes Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells.
T1 0-93 Sentence denotes Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells.
T2 94-148 Sentence denotes A possible signaling role for the Syk tyrosine kinase.
T2 94-148 Sentence denotes A possible signaling role for the Syk tyrosine kinase.
T3 149-260 Sentence denotes Activation of cytoplasmic tyrosine kinases is an important aspect of signal transduction mediated by integrins.
T3 149-260 Sentence denotes Activation of cytoplasmic tyrosine kinases is an important aspect of signal transduction mediated by integrins.
T4 261-511 Sentence denotes In the human monocytic cell line THP-1, either integrin-dependent cell adhesion to fibronectin or ligation of beta 1 integrins with antibodies causes a rapid and intense tyrosine phosphorylation of two sets of proteins of about 65-75 and 120-125 kDa.
T4 261-511 Sentence denotes In the human monocytic cell line THP-1, either integrin-dependent cell adhesion to fibronectin or ligation of beta 1 integrins with antibodies causes a rapid and intense tyrosine phosphorylation of two sets of proteins of about 65-75 and 120-125 kDa.
T5 512-832 Sentence denotes In addition, integrin ligation leads to nuclear translocation of the p50 and p65 subunits of the NF-kappa B transcription factor, to activation of a reporter gene driven by a promoter containing NF-kappa B sites, and to increased levels of mRNAs for immediate-early genes, including the cytokine interleukin (IL)-1 beta.
T5 512-832 Sentence denotes In addition, integrin ligation leads to nuclear translocation of the p50 and p65 subunits of the NF-kappa B transcription factor, to activation of a reporter gene driven by a promoter containing NF-kappa B sites, and to increased levels of mRNAs for immediate-early genes, including the cytokine interleukin (IL)-1 beta.
T6 833-1044 Sentence denotes The tyrosine kinase inhibitors genistein and herbimycin A block both integrin-mediated tyrosine phosphorylation and increases in IL-1 beta message levels, indicating a causal relationship between the two events.
T6 833-1044 Sentence denotes The tyrosine kinase inhibitors genistein and herbimycin A block both integrin-mediated tyrosine phosphorylation and increases in IL-1 beta message levels, indicating a causal relationship between the two events.
T7 1045-1190 Sentence denotes The components tyrosine phosphorylated subsequent to cell adhesion include paxillin, pp125FAK, and the SH2 domain containing tyrosine kinase Syk.
T7 1045-1190 Sentence denotes The components tyrosine phosphorylated subsequent to cell adhesion include paxillin, pp125FAK, and the SH2 domain containing tyrosine kinase Syk.
T8 1191-1305 Sentence denotes In contrast, integrin ligation with antibodies induces tyrosine phosphorylation of Syk but not of FAK or paxillin.
T8 1191-1305 Sentence denotes In contrast, integrin ligation with antibodies induces tyrosine phosphorylation of Syk but not of FAK or paxillin.
T9 1306-1479 Sentence denotes In adhering cells, pre-treatment with cytochalasin D suppresses tyrosine phosphorylation of FAK and paxillin but not of Syk, while IL-1 beta message induction is unaffected.
T9 1306-1479 Sentence denotes In adhering cells, pre-treatment with cytochalasin D suppresses tyrosine phosphorylation of FAK and paxillin but not of Syk, while IL-1 beta message induction is unaffected.
T10 1480-1701 Sentence denotes These observations indicate that the Syk tyrosine kinase may be an important component of an integrin signaling pathway in monocytic cells, leading to activation of NF-kappa B and to increased levels of cytokine messages.
T10 1480-1701 Sentence denotes These observations indicate that the Syk tyrosine kinase may be an important component of an integrin signaling pathway in monocytic cells, leading to activation of NF-kappa B and to increased levels of cytokine messages.