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PubMed:35477563 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
T1 0-252 Sentence denotes Influence of probiotics on the periodontium, the oral microbiota and the immune response during orthodontic treatment in adolescent and adult patients (ProMB Trial): study protocol for a prospective, double-blind, controlled, randomized clinical trial.
T1 0-252 Sentence denotes Influence of probiotics on the periodontium, the oral microbiota and the immune response during orthodontic treatment in adolescent and adult patients (ProMB Trial): study protocol for a prospective, double-blind, controlled, randomized clinical trial.
T2 253-264 Sentence denotes BACKGROUND:
T2 253-264 Sentence denotes BACKGROUND:
T3 265-381 Sentence denotes Orthodontic treatment with fixed appliances is often necessary to correct malocclusions in adolescence or adulthood.
T3 265-381 Sentence denotes Orthodontic treatment with fixed appliances is often necessary to correct malocclusions in adolescence or adulthood.
T4 382-654 Sentence denotes However, oral hygiene is complicated by appliances, and prior studies indicate that they may trigger oral inflammation and dysbiosis of the oral microbiota, especially during the first 3 months after insertion, and, thus, may present a risk for inflammatory oral diseases.
T4 382-654 Sentence denotes However, oral hygiene is complicated by appliances, and prior studies indicate that they may trigger oral inflammation and dysbiosis of the oral microbiota, especially during the first 3 months after insertion, and, thus, may present a risk for inflammatory oral diseases.
T5 655-788 Sentence denotes In recent periodontal therapeutic studies, probiotics have been applied to improve clinical parameters and reduce local inflammation.
T5 655-788 Sentence denotes In recent periodontal therapeutic studies, probiotics have been applied to improve clinical parameters and reduce local inflammation.
T6 789-876 Sentence denotes However, limited knowledge exists concerning the effects of probiotics in orthodontics.
T6 789-876 Sentence denotes However, limited knowledge exists concerning the effects of probiotics in orthodontics.
T7 877-978 Sentence denotes Therefore, the aim of our study is to evaluate the impact of probiotics during orthodontic treatment.
T7 877-978 Sentence denotes Therefore, the aim of our study is to evaluate the impact of probiotics during orthodontic treatment.
T8 979-987 Sentence denotes METHODS:
T8 979-987 Sentence denotes METHODS:
T9 988-1304 Sentence denotes This study is a monocentric, randomized, double blind, controlled clinical study to investigate the effectiveness of daily adjuvant use of Limosilactobacillus reuteri (Prodentis®-lozenges, DSM 17938, ATCC PTA 5289) versus control lozenges during the first three months of orthodontic treatment with fixed appliances.
T9 988-1304 Sentence denotes This study is a monocentric, randomized, double blind, controlled clinical study to investigate the effectiveness of daily adjuvant use of Limosilactobacillus reuteri (Prodentis®-lozenges, DSM 17938, ATCC PTA 5289) versus control lozenges during the first three months of orthodontic treatment with fixed appliances.
T10 1305-1575 Sentence denotes Following power analysis, a total of 34 adolescent patients (age 12-17) and 34 adult patients (18 years and older) undergoing orthodontic treatment at the University Hospital Erlangen will be assigned into 2 parallel groups using a randomization plan for each age group.
T10 1305-1575 Sentence denotes Following power analysis, a total of 34 adolescent patients (age 12-17) and 34 adult patients (18 years and older) undergoing orthodontic treatment at the University Hospital Erlangen will be assigned into 2 parallel groups using a randomization plan for each age group.
T11 1576-1654 Sentence denotes The primary outcome measure is the change of the gingival index after 4 weeks.
T11 1576-1654 Sentence denotes The primary outcome measure is the change of the gingival index after 4 weeks.
T12 1655-1937 Sentence denotes Secondary outcomes include the probing pocket depth, the modified plaque index, the composition of the oral microbiota, the local cytokine expression and-only for adults-serum cytokine levels and the frequencies of cells of the innate and adaptive immune system in peripheral blood.
T12 1655-1937 Sentence denotes Secondary outcomes include the probing pocket depth, the modified plaque index, the composition of the oral microbiota, the local cytokine expression and-only for adults-serum cytokine levels and the frequencies of cells of the innate and adaptive immune system in peripheral blood.
T13 1938-1949 Sentence denotes DISCUSSION:
T13 1938-1949 Sentence denotes DISCUSSION:
T14 1950-2067 Sentence denotes Preventive strategies in everyday orthodontic practice include oral hygiene instructions and regular dental cleaning.
T14 1950-2067 Sentence denotes Preventive strategies in everyday orthodontic practice include oral hygiene instructions and regular dental cleaning.
T15 2068-2138 Sentence denotes Innovative methods, like adjuvant use of oral probiotics, are missing.
T15 2068-2138 Sentence denotes Innovative methods, like adjuvant use of oral probiotics, are missing.
T16 2139-2322 Sentence denotes The aim of this study is to analyse, whether probiotics can improve clinical parameters, reduce inflammation and prevent dysbiosis of the oral microbiota during orthodontic treatment.
T16 2139-2322 Sentence denotes The aim of this study is to analyse, whether probiotics can improve clinical parameters, reduce inflammation and prevent dysbiosis of the oral microbiota during orthodontic treatment.
T17 2323-2480 Sentence denotes If successful, this study will provide the basis for a new strategy of prophylaxis of oral dysbiosis-related diseases during treatment with fixed appliances.
T17 2323-2480 Sentence denotes If successful, this study will provide the basis for a new strategy of prophylaxis of oral dysbiosis-related diseases during treatment with fixed appliances.
T18 2481-2500 Sentence denotes TRIAL REGISTRATION:
T18 2481-2500 Sentence denotes TRIAL REGISTRATION:
T19 2501-2690 Sentence denotes This trial is registered at ClinicalTrials.gov in two parts under the number NCT04598633 (Adolescents, registration date 10/22/2020), and NCT04606186 (Adults, registration date 10/28/2020).
T19 2501-2690 Sentence denotes This trial is registered at ClinicalTrials.gov in two parts under the number NCT04598633 (Adolescents, registration date 10/22/2020), and NCT04606186 (Adults, registration date 10/28/2020).