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PubMed:35351535 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
T1 0-135 Sentence denotes Effect of metformin as an add-on therapy on neuregulin-4 levels and vascular-related complications in adolescents with type 1 diabetes:
T1 0-135 Sentence denotes Effect of metformin as an add-on therapy on neuregulin-4 levels and vascular-related complications in adolescents with type 1 diabetes:
T2 136-166 Sentence denotes A randomized controlled trial.
T2 136-166 Sentence denotes A randomized controlled trial.
T3 167-178 Sentence denotes BACKGROUND:
T3 167-178 Sentence denotes BACKGROUND:
T4 179-305 Sentence denotes Inflammation is closely associated with atherosclerosis and plays a crucial role in the development of cardiovascular disease.
T4 179-305 Sentence denotes Inflammation is closely associated with atherosclerosis and plays a crucial role in the development of cardiovascular disease.
T5 306-409 Sentence denotes Metformin sensitizes body cells to insulin, which may cause a reduction of atherogenic lipid fractions.
T5 306-409 Sentence denotes Metformin sensitizes body cells to insulin, which may cause a reduction of atherogenic lipid fractions.
T6 410-547 Sentence denotes Low neuregulin-4 (Nrg-4) levels, an adipokine, are linked to obesity, insulin resistance, impaired glucose tolerance and type 2 diabetes.
T6 410-547 Sentence denotes Low neuregulin-4 (Nrg-4) levels, an adipokine, are linked to obesity, insulin resistance, impaired glucose tolerance and type 2 diabetes.
T7 548-559 Sentence denotes OBJECTIVES:
T7 548-559 Sentence denotes OBJECTIVES:
T8 560-833 Sentence denotes We assessed the effect of oral supplementation with metformin on glycemic control, neuregulin-4 levels and carotid intima media thickness (CIMT) as a marker for subclinical atherosclerosis in adolescents with type 1 diabetes mellitus (T1DM) and microvascular complications.
T8 560-833 Sentence denotes We assessed the effect of oral supplementation with metformin on glycemic control, neuregulin-4 levels and carotid intima media thickness (CIMT) as a marker for subclinical atherosclerosis in adolescents with type 1 diabetes mellitus (T1DM) and microvascular complications.
T9 834-842 Sentence denotes METHODS:
T9 834-842 Sentence denotes METHODS:
T10 843-1051 Sentence denotes This randomized placebo-controlled trial included 80 type 1 diabetic patients with microvascular complications who were randomly divided to receive either 24 weeks of metformin 500 mg/day or matching placebo.
T10 843-1051 Sentence denotes This randomized placebo-controlled trial included 80 type 1 diabetic patients with microvascular complications who were randomly divided to receive either 24 weeks of metformin 500 mg/day or matching placebo.
T11 1052-1225 Sentence denotes Fasting blood glucose (FBG), HbA1c, C-reactive protein (CRP), urinary albumin creatinine ratio (UACR), lipid profile, Nrg-4 and CIMT were assessed at baseline and study end.
T11 1052-1225 Sentence denotes Fasting blood glucose (FBG), HbA1c, C-reactive protein (CRP), urinary albumin creatinine ratio (UACR), lipid profile, Nrg-4 and CIMT were assessed at baseline and study end.
T12 1226-1234 Sentence denotes RESULTS:
T12 1226-1234 Sentence denotes RESULTS:
T13 1235-1336 Sentence denotes Both groups were well-matched as regards baseline clinical and laboratory data (p greater than 0.05).
T13 1235-1336 Sentence denotes Both groups were well-matched as regards baseline clinical and laboratory data (p greater than 0.05).
T14 1337-1591 Sentence denotes After 24-weeks, metformin therapy for the intervention group resulted in a significant decrease of HbA1c, CRP, UACR, total cholesterol and CIMT while Nrg-4 levels were increased compared with baseline levels (p < 0.001) and with placebo group(p < 0.001).
T14 1337-1591 Sentence denotes After 24-weeks, metformin therapy for the intervention group resulted in a significant decrease of HbA1c, CRP, UACR, total cholesterol and CIMT while Nrg-4 levels were increased compared with baseline levels (p < 0.001) and with placebo group(p < 0.001).
T15 1592-1688 Sentence denotes Baseline Nrg-4 levels were negatively correlated to FBG, HbA1c, total cholesterol, CRP and CIMT.
T15 1592-1688 Sentence denotes Baseline Nrg-4 levels were negatively correlated to FBG, HbA1c, total cholesterol, CRP and CIMT.
T16 1689-1718 Sentence denotes Metformin was well-tolerated.
T16 1689-1718 Sentence denotes Metformin was well-tolerated.
T17 1719-1731 Sentence denotes CONCLUSIONS:
T17 1719-1731 Sentence denotes CONCLUSIONS:
T18 1732-2028 Sentence denotes Oral metformin supplementation once daily for 24 weeks as an adjuvant therapy to intensive insulin in pediatric T1DM was safe and effective in improving glycemic control, dyslipidemia and Nrg-4 levels; hence, it decreased inflammation, microvascular complications and subclinical atherosclerosis.
T18 1732-2028 Sentence denotes Oral metformin supplementation once daily for 24 weeks as an adjuvant therapy to intensive insulin in pediatric T1DM was safe and effective in improving glycemic control, dyslipidemia and Nrg-4 levels; hence, it decreased inflammation, microvascular complications and subclinical atherosclerosis.