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PubMed:35186114 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T1 0-74 Sentence denotes The Protective Mechanism of Dexmedetomidine on Renal in Hemorrhagic Shock.
T1 0-74 Sentence denotes The Protective Mechanism of Dexmedetomidine on Renal in Hemorrhagic Shock.
T2 75-85 Sentence denotes OBJECTIVE:
T2 75-85 Sentence denotes OBJECTIVE:
T3 86-218 Sentence denotes To explore the protective effect of dexmedetomidine on renal function in patients with hemorrhagic shock and its possible mechanism.
T3 86-218 Sentence denotes To explore the protective effect of dexmedetomidine on renal function in patients with hemorrhagic shock and its possible mechanism.
T4 219-227 Sentence denotes METHODS:
T4 219-227 Sentence denotes METHODS:
T5 228-434 Sentence denotes Seventy patients with traumatic hemorrhagic shock requiring surgical treatment were randomly divided into the control group (group C) and the dexmedetomidine group (group D), with 35 patients in each group.
T5 228-434 Sentence denotes Seventy patients with traumatic hemorrhagic shock requiring surgical treatment were randomly divided into the control group (group C) and the dexmedetomidine group (group D), with 35 patients in each group.
T6 435-537 Sentence denotes Patients in both groups were actively treated with volumetric resuscitation while surgical hemostasis.
T6 435-537 Sentence denotes Patients in both groups were actively treated with volumetric resuscitation while surgical hemostasis.
T7 538-813 Sentence denotes Group D was given dexmedetomidine 0.5 μg/kg before skin incision after anesthesia induction, for 10 min, followed by intravenous infusion at a rate of 0.4 μg·kg-1·h-1 until 30 min before surgery, and group C was given equal volume of normal saline before skin resection (H1).
T7 538-813 Sentence denotes Group D was given dexmedetomidine 0.5 μg/kg before skin incision after anesthesia induction, for 10 min, followed by intravenous infusion at a rate of 0.4 μg·kg-1·h-1 until 30 min before surgery, and group C was given equal volume of normal saline before skin resection (H1).
T8 814-1044 Sentence denotes Venous blood was collected 2 h (H2) and 4 h (H4) after skin resection, and plasma levels of BUN, creatinine (SCr), lipid peroxides (MDA), and inflammatory mediators IL-6 and IL-8 were measured on the 1st and 2nd day after surgery.
T8 814-1044 Sentence denotes Venous blood was collected 2 h (H2) and 4 h (H4) after skin resection, and plasma levels of BUN, creatinine (SCr), lipid peroxides (MDA), and inflammatory mediators IL-6 and IL-8 were measured on the 1st and 2nd day after surgery.
T9 1045-1053 Sentence denotes RESULTS:
T9 1045-1053 Sentence denotes RESULTS:
T10 1054-1231 Sentence denotes Compared with H1, BUN and SCr levels had no significant difference at 2 h and 4 h after skin resection but significantly decreased at 1 and 2 postoperative days (D1) (P < 0.05).
T10 1054-1231 Sentence denotes Compared with H1, BUN and SCr levels had no significant difference at 2 h and 4 h after skin resection but significantly decreased at 1 and 2 postoperative days (D1) (P < 0.05).
T11 1232-1436 Sentence denotes There were significant differences in MDA, IL-6, and IL-8 at 2 and 4 h after skin resection (P < 0.05), but there were no significant differences at 1 day after surgery (D1) and 2 days after surgery (D2).
T11 1232-1436 Sentence denotes There were significant differences in MDA, IL-6, and IL-8 at 2 and 4 h after skin resection (P < 0.05), but there were no significant differences at 1 day after surgery (D1) and 2 days after surgery (D2).
T12 1437-1700 Sentence denotes Compared with group C, the levels of MDA, IL-6, and IL-8 in group U were significantly decreased at 2 h and 4 h after skin resection (P < 0.05), and the levels of BUN and SCr in group U were significantly decreased at 1 and 2 days after skin resection (P < 0.05).
T12 1437-1700 Sentence denotes Compared with group C, the levels of MDA, IL-6, and IL-8 in group U were significantly decreased at 2 h and 4 h after skin resection (P < 0.05), and the levels of BUN and SCr in group U were significantly decreased at 1 and 2 days after skin resection (P < 0.05).
T13 1701-1712 Sentence denotes CONCLUSION:
T13 1701-1712 Sentence denotes CONCLUSION:
T14 1713-1925 Sentence denotes Dexmedetomidine can effectively inhibit the release of oxygen free radicals in the shock stage and the shock recovery stage in patients with hemorrhagic trauma shock and has a protective effect on renal function.
T14 1713-1925 Sentence denotes Dexmedetomidine can effectively inhibit the release of oxygen free radicals in the shock stage and the shock recovery stage in patients with hemorrhagic trauma shock and has a protective effect on renal function.