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PubMed:34956584 JSONTXT

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Id Subject Object Predicate Lexical cue
T1 0-130 Sentence denotes Neuroprotective Effects of Hesperetin in Regulating Microglia Polarization after Ischemic Stroke by Inhibiting TLR4/NF-κB Pathway.
T1 0-130 Sentence denotes Neuroprotective Effects of Hesperetin in Regulating Microglia Polarization after Ischemic Stroke by Inhibiting TLR4/NF-κB Pathway.
T2 131-296 Sentence denotes This study aimed to explore the influence of hesperidin on the polarization of microglia to clarify the key mechanism of regulating the polarization of M2 microglia.
T2 131-296 Sentence denotes This study aimed to explore the influence of hesperidin on the polarization of microglia to clarify the key mechanism of regulating the polarization of M2 microglia.
T3 297-495 Sentence denotes C57BL/6 mice were randomly divided into middle cerebral artery occlusion model group (MCAO group), MCAO + hesperidin treatment group (MCAO + hesperidin group), and sham group (sham operation group).
T3 297-495 Sentence denotes C57BL/6 mice were randomly divided into middle cerebral artery occlusion model group (MCAO group), MCAO + hesperidin treatment group (MCAO + hesperidin group), and sham group (sham operation group).
T4 496-572 Sentence denotes The mice were assessed with neurological scores for their functional status.
T4 496-572 Sentence denotes The mice were assessed with neurological scores for their functional status.
T5 573-669 Sentence denotes 2,3,5-Triphenyltetrazole chloride (TTC) was used to determine the volume of cerebral infarction.
T5 573-669 Sentence denotes 2,3,5-Triphenyltetrazole chloride (TTC) was used to determine the volume of cerebral infarction.
T6 670-742 Sentence denotes Hematoxylin and eosin (H&E) staining was performed to detect brain loss.
T6 670-742 Sentence denotes Hematoxylin and eosin (H&E) staining was performed to detect brain loss.
T7 743-845 Sentence denotes The system with 1% O2, 5% CO2, and 92% N2 was applied to establish BV2 in vitro model induced by MCAO.
T7 743-845 Sentence denotes The system with 1% O2, 5% CO2, and 92% N2 was applied to establish BV2 in vitro model induced by MCAO.
T8 846-939 Sentence denotes TNF-α, IL-1β, TGF-β, and IL-10 levels of cytokines in the supernatant were detected by ELISA.
T8 846-939 Sentence denotes TNF-α, IL-1β, TGF-β, and IL-10 levels of cytokines in the supernatant were detected by ELISA.
T9 940-1060 Sentence denotes RT-qPCR was used to detect mRNA levels of M1 iNOS, CD11b, CD32, and CD86, and mRNA levels of M2 CD206, Arg-1, and TGF-β.
T9 940-1060 Sentence denotes RT-qPCR was used to detect mRNA levels of M1 iNOS, CD11b, CD32, and CD86, and mRNA levels of M2 CD206, Arg-1, and TGF-β.
T10 1061-1193 Sentence denotes The Iba-1, iNOS, and Arg-1 of microglia and protein levels of TLR4 and p-NF-κB related to the pathway were detected by Western blot.
T10 1061-1193 Sentence denotes The Iba-1, iNOS, and Arg-1 of microglia and protein levels of TLR4 and p-NF-κB related to the pathway were detected by Western blot.
T11 1194-1447 Sentence denotes After treatment with hesperidin, BV2 cells induced by MCAO in vitro can reduce the proinflammatory cytokines of TNF-α and IL-1β significantly, further upregulating anti-inflammatory cytokines of TGF-β, IL-10 while inhibiting TLR4 and p-NF-κB expression.
T11 1194-1447 Sentence denotes After treatment with hesperidin, BV2 cells induced by MCAO in vitro can reduce the proinflammatory cytokines of TNF-α and IL-1β significantly, further upregulating anti-inflammatory cytokines of TGF-β, IL-10 while inhibiting TLR4 and p-NF-κB expression.
T12 1448-1608 Sentence denotes The MCAO-induced BV2 cells treated by TLR-4 inhibitor TAK-242 and NF-κB inhibitor BAY 11-7082 had similar polarization effects to those treated with hesperidin.
T12 1448-1608 Sentence denotes The MCAO-induced BV2 cells treated by TLR-4 inhibitor TAK-242 and NF-κB inhibitor BAY 11-7082 had similar polarization effects to those treated with hesperidin.
T13 1609-1752 Sentence denotes This study found that hesperetin gavage treatment can improve the neurological deficit and regulate the polarization of microglia in MCAO mice.
T13 1609-1752 Sentence denotes This study found that hesperetin gavage treatment can improve the neurological deficit and regulate the polarization of microglia in MCAO mice.
T14 1753-1975 Sentence denotes In vitro experiments further verified that hesperidin plays a neuroprotective role by inhibiting the TLR4-NF-κB pathway, thus providing new targets and strategies for neuroprotection and nerve repair after ischemic stroke.
T14 1753-1975 Sentence denotes In vitro experiments further verified that hesperidin plays a neuroprotective role by inhibiting the TLR4-NF-κB pathway, thus providing new targets and strategies for neuroprotection and nerve repair after ischemic stroke.