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PubMed:34259316 JSONTXT 2 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-94 Sentence denotes Retardant effect of dihydroartemisinin on ulcerative colitis in a JAK2/STAT3-dependent manner.
T1 0-94 Sentence denotes Retardant effect of dihydroartemisinin on ulcerative colitis in a JAK2/STAT3-dependent manner.
T2 95-197 Sentence denotes Dihydroartemisinin (DHA) is a semi-synthetic derivative and the main active metabolite of artemisinin.
T2 95-197 Sentence denotes Dihydroartemisinin (DHA) is a semi-synthetic derivative and the main active metabolite of artemisinin.
T3 198-328 Sentence denotes The purpose of this study was to investigate the effect of DHA on the ulcerative colitis (UC) in both in vivo and in vitro models.
T3 198-328 Sentence denotes The purpose of this study was to investigate the effect of DHA on the ulcerative colitis (UC) in both in vivo and in vitro models.
T4 329-445 Sentence denotes Weight, survival rate, colon length, and Disease Activity Index score were used to evaluate the severity of colitis.
T4 329-445 Sentence denotes Weight, survival rate, colon length, and Disease Activity Index score were used to evaluate the severity of colitis.
T5 446-683 Sentence denotes Reverse transcription quantitative polymerase chain reaction and enzyme-linked immunosorbent assay were used to detect the expressions of cytokines interleukin (IL)-1, IL-1β, IL-4, IL-6, IL-10, IL-12, and tumor necrosis factor-α (TNF-α).
T5 446-683 Sentence denotes Reverse transcription quantitative polymerase chain reaction and enzyme-linked immunosorbent assay were used to detect the expressions of cytokines interleukin (IL)-1, IL-1β, IL-4, IL-6, IL-10, IL-12, and tumor necrosis factor-α (TNF-α).
T6 684-890 Sentence denotes The expressions of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3), and the phosphorylation of JAK2 (p-JAK2) and STAT3 (p-STAT3), were measured by western blot analysis.
T6 684-890 Sentence denotes The expressions of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3), and the phosphorylation of JAK2 (p-JAK2) and STAT3 (p-STAT3), were measured by western blot analysis.
T7 891-1001 Sentence denotes Western blot analysis and immunohistochemistry were used to detect the expressions of tight junction proteins.
T7 891-1001 Sentence denotes Western blot analysis and immunohistochemistry were used to detect the expressions of tight junction proteins.
T8 1002-1174 Sentence denotes We found that the weights and colon lengths of mice in dextran sodium sulfate (DSS)+DHA group were significantly lower and longer than those in the DSS group, respectively.
T8 1002-1174 Sentence denotes We found that the weights and colon lengths of mice in dextran sodium sulfate (DSS)+DHA group were significantly lower and longer than those in the DSS group, respectively.
T9 1175-1409 Sentence denotes Compared with those in the DSS group, the expressions of IL-1β, IL-6, IL-17, and TNF-α in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.
T9 1175-1409 Sentence denotes Compared with those in the DSS group, the expressions of IL-1β, IL-6, IL-17, and TNF-α in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.
T10 1410-1483 Sentence denotes DHA largely increased the expressions of zonula occludens-1 and occludin.
T10 1410-1483 Sentence denotes DHA largely increased the expressions of zonula occludens-1 and occludin.
T11 1484-1696 Sentence denotes Western blot analysis and/or immunohistochemical staining analysis showed that the expressions of JAK2, STAT3, p-JAK2, and p-STAT3 in DSS+DHA and DSS+5-ASA groups were significantly lower than those in DSS group.
T11 1484-1696 Sentence denotes Western blot analysis and/or immunohistochemical staining analysis showed that the expressions of JAK2, STAT3, p-JAK2, and p-STAT3 in DSS+DHA and DSS+5-ASA groups were significantly lower than those in DSS group.
T12 1697-1741 Sentence denotes DHA has a specific therapeutic effect on UC.
T12 1697-1741 Sentence denotes DHA has a specific therapeutic effect on UC.
T13 1742-1844 Sentence denotes The anti-inflammatory mechanism of DHA is related to the blockage of the JAK2/STAT3 signaling pathway.
T13 1742-1844 Sentence denotes The anti-inflammatory mechanism of DHA is related to the blockage of the JAK2/STAT3 signaling pathway.
T14 1845-1972 Sentence denotes These findings provide evidence that DHA may be a useful drug and is expected to become a promising new treatment for human UC.
T14 1845-1972 Sentence denotes These findings provide evidence that DHA may be a useful drug and is expected to become a promising new treatment for human UC.