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PubMed:33745264 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T1 0-178 Sentence denotes The comparative effects of intravenous iron on oxidative stress and inflammation in patients with chronic kidney disease and iron deficiency: a randomized controlled pilot study.
T1 0-178 Sentence denotes The comparative effects of intravenous iron on oxidative stress and inflammation in patients with chronic kidney disease and iron deficiency: a randomized controlled pilot study.
T2 179-190 Sentence denotes BACKGROUND:
T2 179-190 Sentence denotes BACKGROUND:
T3 191-327 Sentence denotes Concerns exist regarding the pro-oxidant and inflammatory potential of intravenous (IV) iron due to labile plasma iron (LPI) generation.
T3 191-327 Sentence denotes Concerns exist regarding the pro-oxidant and inflammatory potential of intravenous (IV) iron due to labile plasma iron (LPI) generation.
T4 328-428 Sentence denotes This IRON-CKD trial compared the effects of different IV irons on oxidative stress and inflammation.
T4 328-428 Sentence denotes This IRON-CKD trial compared the effects of different IV irons on oxidative stress and inflammation.
T5 429-437 Sentence denotes METHODS:
T5 429-437 Sentence denotes METHODS:
T6 438-796 Sentence denotes In this randomized open-label explorative single-center study in the United Kingdom, non-dialysis-dependent chronic kidney disease (CKD) patients with iron deficiency were randomized (1:1:1:1) to receive a single infusion of 200 mg iron dextran, or 200 mg iron sucrose (IS), or 200 mg or 1,000 mg ferric derisomaltose (FDI) and were followed up for 3 months.
T6 438-796 Sentence denotes In this randomized open-label explorative single-center study in the United Kingdom, non-dialysis-dependent chronic kidney disease (CKD) patients with iron deficiency were randomized (1:1:1:1) to receive a single infusion of 200 mg iron dextran, or 200 mg iron sucrose (IS), or 200 mg or 1,000 mg ferric derisomaltose (FDI) and were followed up for 3 months.
T7 797-879 Sentence denotes The primary outcomes measured were induction of oxidative stress and inflammation.
T7 797-879 Sentence denotes The primary outcomes measured were induction of oxidative stress and inflammation.
T8 880-965 Sentence denotes Secondarily, efficacy, vascular function, quality of life, and safety were monitored.
T8 880-965 Sentence denotes Secondarily, efficacy, vascular function, quality of life, and safety were monitored.
T9 966-974 Sentence denotes RESULTS:
T9 966-974 Sentence denotes RESULTS:
T10 975-1004 Sentence denotes Forty patients were enrolled.
T10 975-1004 Sentence denotes Forty patients were enrolled.
T11 1005-1088 Sentence denotes No significant rise in oxidative stress existed, regardless of preparation or dose.
T11 1005-1088 Sentence denotes No significant rise in oxidative stress existed, regardless of preparation or dose.
T12 1089-1232 Sentence denotes There was a significant rise in LPI with 1,000 mg FDI at 2 hours that normalized within a week, not impacting oxidative stress or inflammation.
T12 1089-1232 Sentence denotes There was a significant rise in LPI with 1,000 mg FDI at 2 hours that normalized within a week, not impacting oxidative stress or inflammation.
T13 1233-1288 Sentence denotes A delayed rise in C-reactive protein was noted with IS.
T13 1233-1288 Sentence denotes A delayed rise in C-reactive protein was noted with IS.
T14 1289-1394 Sentence denotes High-dose FDI produced a sustained serum ferritin increase (mean ± standard error of the mean of predose:
T14 1289-1394 Sentence denotes High-dose FDI produced a sustained serum ferritin increase (mean ± standard error of the mean of predose:
T15 1395-1422 Sentence denotes 69.1 ± 18.4 μg/L, 3 months:
T15 1395-1422 Sentence denotes 69.1 ± 18.4 μg/L, 3 months:
T16 1423-1453 Sentence denotes 271.0 ± 83.3 μg/L; p = 0.007).
T16 1423-1453 Sentence denotes 271.0 ± 83.3 μg/L; p = 0.007).
T17 1454-1492 Sentence denotes Hemoglobin remained stable throughout.
T17 1454-1492 Sentence denotes Hemoglobin remained stable throughout.
T18 1493-1550 Sentence denotes No adverse drug reactions were recorded during the study.
T18 1493-1550 Sentence denotes No adverse drug reactions were recorded during the study.
T19 1551-1562 Sentence denotes CONCLUSION:
T19 1551-1562 Sentence denotes CONCLUSION:
T20 1563-1665 Sentence denotes A single dose of IV iron in CKD patients does not trigger oxidative stress or inflammation biomarkers.
T20 1563-1665 Sentence denotes A single dose of IV iron in CKD patients does not trigger oxidative stress or inflammation biomarkers.
T21 1666-1925 Sentence denotes Third-generation IV irons have a reassuring safety profile, and high-dose FDI produced a sustained serum ferritin rise and more efficient iron repletion, with no significant pro-oxidant or inflammatory signals when compared to a lower dose and other IV irons.
T21 1666-1925 Sentence denotes Third-generation IV irons have a reassuring safety profile, and high-dose FDI produced a sustained serum ferritin rise and more efficient iron repletion, with no significant pro-oxidant or inflammatory signals when compared to a lower dose and other IV irons.