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PubMed:33062720 JSONTXT 2 Projects

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Id Subject Object Predicate Lexical cue
T1 0-112 Sentence denotes Elucidating the Pivotal Immunomodulatory and Anti-Inflammatory Potentials of Chloroquine and Hydroxychloroquine.
T1 0-112 Sentence denotes Elucidating the Pivotal Immunomodulatory and Anti-Inflammatory Potentials of Chloroquine and Hydroxychloroquine.
T2 113-247 Sentence denotes Chloroquine (CQ) and hydroxychloroquine (HCQ) are derivatives of 4-aminoquinoline compounds with over 60 years of safe clinical usage.
T2 113-247 Sentence denotes Chloroquine (CQ) and hydroxychloroquine (HCQ) are derivatives of 4-aminoquinoline compounds with over 60 years of safe clinical usage.
T3 248-366 Sentence denotes CQ and HCQ are able to inhibit the production of cytokines such as interleukin- (IL-) 1, IL-2, IL-6, IL-17, and IL-22.
T3 248-366 Sentence denotes CQ and HCQ are able to inhibit the production of cytokines such as interleukin- (IL-) 1, IL-2, IL-6, IL-17, and IL-22.
T4 367-483 Sentence denotes Also, CQ and HCQ inhibit the production of interferon- (IFN-) α and IFN-γ and/or tumor necrotizing factor- (TNF-) α.
T4 367-483 Sentence denotes Also, CQ and HCQ inhibit the production of interferon- (IFN-) α and IFN-γ and/or tumor necrotizing factor- (TNF-) α.
T5 484-659 Sentence denotes Furthermore, CQ blocks the production of prostaglandins (PGs) in the intact cell by inhibiting substrate accessibility of arachidonic acid necessary for the production of PGs.
T5 484-659 Sentence denotes Furthermore, CQ blocks the production of prostaglandins (PGs) in the intact cell by inhibiting substrate accessibility of arachidonic acid necessary for the production of PGs.
T6 660-828 Sentence denotes Moreover, CQ affects the stability between T-helper cell (Th) 1 and Th2 cytokine secretion by augmenting IL-10 production in peripheral blood mononuclear cells (PBMCs).
T6 660-828 Sentence denotes Moreover, CQ affects the stability between T-helper cell (Th) 1 and Th2 cytokine secretion by augmenting IL-10 production in peripheral blood mononuclear cells (PBMCs).
T7 829-1010 Sentence denotes Additionally, CQ is capable of blocking lipopolysaccharide- (LPS-) triggered stimulation of extracellular signal-modulated extracellular signal-regulated kinases 1/2 in human PBMCs.
T7 829-1010 Sentence denotes Additionally, CQ is capable of blocking lipopolysaccharide- (LPS-) triggered stimulation of extracellular signal-modulated extracellular signal-regulated kinases 1/2 in human PBMCs.
T8 1011-1161 Sentence denotes HCQ at clinical levels effectively blocks CpG-triggered class-switched memory B-cells from differentiating into plasmablasts as well as producing IgG.
T8 1011-1161 Sentence denotes HCQ at clinical levels effectively blocks CpG-triggered class-switched memory B-cells from differentiating into plasmablasts as well as producing IgG.
T9 1162-1229 Sentence denotes Also, HCQ inhibits cytokine generation from all the B-cell subsets.
T9 1162-1229 Sentence denotes Also, HCQ inhibits cytokine generation from all the B-cell subsets.
T10 1230-1289 Sentence denotes IgM memory B-cells exhibits the utmost cytokine production.
T10 1230-1289 Sentence denotes IgM memory B-cells exhibits the utmost cytokine production.
T11 1290-1358 Sentence denotes Nevertheless, CQ triggers the production of reactive oxygen species.
T11 1290-1358 Sentence denotes Nevertheless, CQ triggers the production of reactive oxygen species.
T12 1359-1446 Sentence denotes A rare, but serious, side effect of CQ or HCQ in nondiabetic patients is hypoglycaemia.
T12 1359-1446 Sentence denotes A rare, but serious, side effect of CQ or HCQ in nondiabetic patients is hypoglycaemia.
T13 1447-1594 Sentence denotes Thus, in critically ill patients, CQ and HCQ are most likely to deplete all the energy stores of the body leaving the patient very weak and sicker.
T13 1447-1594 Sentence denotes Thus, in critically ill patients, CQ and HCQ are most likely to deplete all the energy stores of the body leaving the patient very weak and sicker.
T14 1595-1748 Sentence denotes We advocate that, during clinical usage of CQ and HCQ in critically ill patients, it is very essential to strengthen the CQ or HCQ with glucose infusion.
T14 1595-1748 Sentence denotes We advocate that, during clinical usage of CQ and HCQ in critically ill patients, it is very essential to strengthen the CQ or HCQ with glucose infusion.
T15 1749-1821 Sentence denotes CQ and HCQ are thus potential inhibitors of the COVID-19 cytokine storm.
T15 1749-1821 Sentence denotes CQ and HCQ are thus potential inhibitors of the COVID-19 cytokine storm.