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PubMed:32970989 JSONTXT 33 Projects

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Id Subject Object Predicate Lexical cue
T1 0-66 Sentence denotes SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.
T1 0-66 Sentence denotes SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.
T2 67-235 Sentence denotes We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and angiotensin-converting enzyme 2 (ACE2) through its receptor-binding domain (RBD).
T2 67-235 Sentence denotes We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and angiotensin-converting enzyme 2 (ACE2) through its receptor-binding domain (RBD).
T3 236-333 Sentence denotes Docking studies suggest a heparin/heparan sulfate-binding site adjacent to the ACE2-binding site.
T3 236-333 Sentence denotes Docking studies suggest a heparin/heparan sulfate-binding site adjacent to the ACE2-binding site.
T4 334-473 Sentence denotes Both ACE2 and heparin can bind independently to spike protein in vitro, and a ternary complex can be generated using heparin as a scaffold.
T4 334-473 Sentence denotes Both ACE2 and heparin can bind independently to spike protein in vitro, and a ternary complex can be generated using heparin as a scaffold.
T5 474-592 Sentence denotes Electron micrographs of spike protein suggests that heparin enhances the open conformation of the RBD that binds ACE2.
T5 474-592 Sentence denotes Electron micrographs of spike protein suggests that heparin enhances the open conformation of the RBD that binds ACE2.
T6 593-666 Sentence denotes On cells, spike protein binding depends on both heparan sulfate and ACE2.
T6 593-666 Sentence denotes On cells, spike protein binding depends on both heparan sulfate and ACE2.
T7 667-865 Sentence denotes Unfractionated heparin, non-anticoagulant heparin, heparin lyases, and lung heparan sulfate potently block spike protein binding and/or infection by pseudotyped virus and authentic SARS-CoV-2 virus.
T7 667-865 Sentence denotes Unfractionated heparin, non-anticoagulant heparin, heparin lyases, and lung heparan sulfate potently block spike protein binding and/or infection by pseudotyped virus and authentic SARS-CoV-2 virus.
T8 866-991 Sentence denotes We suggest a model in which viral attachment and infection involves heparan sulfate-dependent enhancement of binding to ACE2.
T8 866-991 Sentence denotes We suggest a model in which viral attachment and infection involves heparan sulfate-dependent enhancement of binding to ACE2.
T9 992-1116 Sentence denotes Manipulation of heparan sulfate or inhibition of viral adhesion by exogenous heparin presents new therapeutic opportunities.
T9 992-1116 Sentence denotes Manipulation of heparan sulfate or inhibition of viral adhesion by exogenous heparin presents new therapeutic opportunities.