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PubMed:32831324 JSONTXT 21 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-112 Sentence denotes Cutaneous susceptibility to SARS-CoV-2 infection according to the expression of viral entry factors in the skin.
T1 0-112 Sentence denotes Cutaneous susceptibility to SARS-CoV-2 infection according to the expression of viral entry factors in the skin.
T2 113-230 Sentence denotes Susceptibilidad cutánea a la infección por SARS-CoV-2 según la expresión de los factores de entrada viral en la piel.
T2 113-230 Sentence denotes Susceptibilidad cutánea a la infección por SARS-CoV-2 según la expresión de los factores de entrada viral en la piel.
T3 231-244 Sentence denotes Introduction:
T3 231-244 Sentence denotes Introduction:
T4 245-430 Sentence denotes Reports of dermatological manifestations in patients with COVID-19 suggest a possible cutaneous tropism of SARS-CoV-2; however, the capacity of this virus to infect the skin is unknown.
T4 245-430 Sentence denotes Reports of dermatological manifestations in patients with COVID-19 suggest a possible cutaneous tropism of SARS-CoV-2; however, the capacity of this virus to infect the skin is unknown.
T5 431-441 Sentence denotes Objective:
T5 431-441 Sentence denotes Objective:
T6 442-588 Sentence denotes To determine the susceptibility of the skin to SARS-CoV-2 infection based on the expression of viral entry factors ACE2 and TMPRSS2 in this organ.
T6 442-588 Sentence denotes To determine the susceptibility of the skin to SARS-CoV-2 infection based on the expression of viral entry factors ACE2 and TMPRSS2 in this organ.
T7 589-596 Sentence denotes Method:
T7 589-596 Sentence denotes Method:
T8 597-830 Sentence denotes A comprehensive analysis of human tissue gene expression databases was carried out looking for the presence of the ACE2 and TMPRSS2 genes in the skin. mRNA expression of these genes in skin-derived human cell lines was also assessed.
T8 597-830 Sentence denotes A comprehensive analysis of human tissue gene expression databases was carried out looking for the presence of the ACE2 and TMPRSS2 genes in the skin. mRNA expression of these genes in skin-derived human cell lines was also assessed.
T9 831-839 Sentence denotes Results:
T9 831-839 Sentence denotes Results:
T10 840-961 Sentence denotes The analyses showed high co-expression of ACE2 and TMPRSS2 in the gastrointestinal tract and kidney, but not in the skin.
T10 840-961 Sentence denotes The analyses showed high co-expression of ACE2 and TMPRSS2 in the gastrointestinal tract and kidney, but not in the skin.
T11 962-1115 Sentence denotes Only the human immortalized keratinocyte HaCaT cell line expressed detectable levels of ACE2, and no cell line originating in the skin expressed TMPRSS2.
T11 962-1115 Sentence denotes Only the human immortalized keratinocyte HaCaT cell line expressed detectable levels of ACE2, and no cell line originating in the skin expressed TMPRSS2.
T12 1116-1128 Sentence denotes Conclusions:
T12 1116-1128 Sentence denotes Conclusions:
T13 1129-1248 Sentence denotes Our results suggest that cutaneous manifestations in patients with COVID-19 cannot be directly attributed to the virus.
T13 1129-1248 Sentence denotes Our results suggest that cutaneous manifestations in patients with COVID-19 cannot be directly attributed to the virus.
T14 1249-1442 Sentence denotes It is possible that cutaneous blood vessels endothelial damage, as well as the effect of circulating inflammatory mediators produced in response to the virus, are the cause of skin involvement.
T14 1249-1442 Sentence denotes It is possible that cutaneous blood vessels endothelial damage, as well as the effect of circulating inflammatory mediators produced in response to the virus, are the cause of skin involvement.