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Id Subject Object Predicate Lexical cue
T1 0-89 Sentence denotes Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19.
T1 0-89 Sentence denotes Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19.
T2 90-181 Sentence denotes Coronavirus disease 2019 (COVID-19) is a pandemic with no specific drugs and high fatality.
T2 90-181 Sentence denotes Coronavirus disease 2019 (COVID-19) is a pandemic with no specific drugs and high fatality.
T3 182-235 Sentence denotes The most urgent need is to find effective treatments.
T3 182-235 Sentence denotes The most urgent need is to find effective treatments.
T4 236-366 Sentence denotes We sought to determine whether hydroxychloroquine (HCQ) application may reduce the death risk of critically ill COVID-19 patients.
T4 236-366 Sentence denotes We sought to determine whether hydroxychloroquine (HCQ) application may reduce the death risk of critically ill COVID-19 patients.
T5 367-543 Sentence denotes In this retrospective study, we included 550 critically ill COVID-19 patients who need mechanical ventilation in Tongji Hospital, Wuhan, from February 1, 2020 to April 4, 2020.
T5 367-543 Sentence denotes In this retrospective study, we included 550 critically ill COVID-19 patients who need mechanical ventilation in Tongji Hospital, Wuhan, from February 1, 2020 to April 4, 2020.
T6 544-764 Sentence denotes All 550 patients received comparable basic treatments including antiviral drugs and antibiotics, and 48 of them were treated with oral HCQ treatment (200 mg twice a day for 7-10 days) in addition to the basic treatments.
T6 544-764 Sentence denotes All 550 patients received comparable basic treatments including antiviral drugs and antibiotics, and 48 of them were treated with oral HCQ treatment (200 mg twice a day for 7-10 days) in addition to the basic treatments.
T7 765-911 Sentence denotes Primary endpoint is fatality of patients, and inflammatory cytokine levels were compared between HCQ and non-hydroxychloroquine (NHCQ) treatments.
T7 765-911 Sentence denotes Primary endpoint is fatality of patients, and inflammatory cytokine levels were compared between HCQ and non-hydroxychloroquine (NHCQ) treatments.
T8 912-1046 Sentence denotes We found that fatalities are 18.8% (9/48) in HCQ group, which is significantly lower than 47.4% (238/502) in the NHCQ group (P<0.001).
T8 912-1046 Sentence denotes We found that fatalities are 18.8% (9/48) in HCQ group, which is significantly lower than 47.4% (238/502) in the NHCQ group (P<0.001).
T9 1047-1182 Sentence denotes The time of hospital stay before patient death is 15 (10-21) days and 8 (4-14) days for the HCQ and NHCQ groups, respectively (P<0.05).
T9 1047-1182 Sentence denotes The time of hospital stay before patient death is 15 (10-21) days and 8 (4-14) days for the HCQ and NHCQ groups, respectively (P<0.05).
T10 1183-1436 Sentence denotes The levels of inflammatory cytokine IL-6 were significantly reduced from 22.2 (8.3-118.9) pg mL-1 at the beginning of the treatment to 5.2 (3.0-23.4) pg mL-1 (P<0.05) at the end of the treatment in the HCQ group but there is no change in the NHCQ group.
T10 1183-1436 Sentence denotes The levels of inflammatory cytokine IL-6 were significantly reduced from 22.2 (8.3-118.9) pg mL-1 at the beginning of the treatment to 5.2 (3.0-23.4) pg mL-1 (P<0.05) at the end of the treatment in the HCQ group but there is no change in the NHCQ group.
T11 1437-1647 Sentence denotes These data demonstrate that addition of HCQ on top of the basic treatments is highly effective in reducing the fatality of critically ill patients of COVID-19 through attenuation of inflammatory cytokine storm.
T11 1437-1647 Sentence denotes These data demonstrate that addition of HCQ on top of the basic treatments is highly effective in reducing the fatality of critically ill patients of COVID-19 through attenuation of inflammatory cytokine storm.
T12 1648-1832 Sentence denotes Therefore, HCQ should be prescribed as a part of treatment for critically ill COVID-19 patients, with possible outcome of saving lives. hydroxychloroquine, IL-6, mortalities, COVID-19.
T12 1648-1832 Sentence denotes Therefore, HCQ should be prescribed as a part of treatment for critically ill COVID-19 patients, with possible outcome of saving lives. hydroxychloroquine, IL-6, mortalities, COVID-19.