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PubMed:32401405 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
T1 0-130 Sentence denotes Antihyperglycemic properties of hydroxychloroquine in patients with diabetes: risks and benefits at the time of COVID-19 pandemic.
T1 0-130 Sentence denotes Antihyperglycemic properties of hydroxychloroquine in patients with diabetes: risks and benefits at the time of COVID-19 pandemic.
T2 131-300 Sentence denotes The antimalarial drug hydroxychloroquine (HCQ) has long been used as a disease-modifying antirheumatic drug for the treatment of several inflammatory rheumatic diseases.
T2 131-300 Sentence denotes The antimalarial drug hydroxychloroquine (HCQ) has long been used as a disease-modifying antirheumatic drug for the treatment of several inflammatory rheumatic diseases.
T3 301-425 Sentence denotes Over the last three decades, various studies have shown that HCQ plays also a role in the regulation of glucose homeostasis.
T3 301-425 Sentence denotes Over the last three decades, various studies have shown that HCQ plays also a role in the regulation of glucose homeostasis.
T4 426-782 Sentence denotes Although the mechanisms of action underlying the glucose-lowering properties of HCQ are still not entirely clear, evidence suggests that this drug may exert multifaceted effects on glucose regulation, including improvement of insulin sensitivity, increase of insulin secretion, reduction of hepatic insulin clearance and reduction of systemic inflammation.
T4 426-782 Sentence denotes Although the mechanisms of action underlying the glucose-lowering properties of HCQ are still not entirely clear, evidence suggests that this drug may exert multifaceted effects on glucose regulation, including improvement of insulin sensitivity, increase of insulin secretion, reduction of hepatic insulin clearance and reduction of systemic inflammation.
T5 783-946 Sentence denotes Preliminary studies have shown the safety and efficacy of HCQ (at a dose ranging from 400 to 600 mg/day) in patients with type 2 diabetes over a short-term period.
T5 783-946 Sentence denotes Preliminary studies have shown the safety and efficacy of HCQ (at a dose ranging from 400 to 600 mg/day) in patients with type 2 diabetes over a short-term period.
T6 947-1066 Sentence denotes In 2014, HCQ has been approved in India as an add-on hypoglycemic agent for patients with uncontrolled type 2 diabetes.
T6 947-1066 Sentence denotes In 2014, HCQ has been approved in India as an add-on hypoglycemic agent for patients with uncontrolled type 2 diabetes.
T7 1067-1231 Sentence denotes However, large randomized controlled trials are needed to establish the safety and efficacy profile of HCQ in patients with type 2 diabetes over a long-term period.
T7 1067-1231 Sentence denotes However, large randomized controlled trials are needed to establish the safety and efficacy profile of HCQ in patients with type 2 diabetes over a long-term period.
T8 1232-1386 Sentence denotes With regard to the COVID-19 pandemic, several medications (including HCQ) have been used as off-label drugs due to the lack of proven effective therapies.
T8 1232-1386 Sentence denotes With regard to the COVID-19 pandemic, several medications (including HCQ) have been used as off-label drugs due to the lack of proven effective therapies.
T9 1387-1472 Sentence denotes However, emerging evidence shows limited benefit from HCQ use in COVID-19 in general.
T9 1387-1472 Sentence denotes However, emerging evidence shows limited benefit from HCQ use in COVID-19 in general.
T10 1473-1750 Sentence denotes The aim of this manuscript is to comprehensively summarize the current knowledge on the antihyperglycemic properties of HCQ and to critically evaluate the potential risks and benefits related to HCQ use in patients with diabetes, even in light of the current pandemic scenario.
T10 1473-1750 Sentence denotes The aim of this manuscript is to comprehensively summarize the current knowledge on the antihyperglycemic properties of HCQ and to critically evaluate the potential risks and benefits related to HCQ use in patients with diabetes, even in light of the current pandemic scenario.
T11 1751-1790 Sentence denotes This article is protected by copyright.
T11 1751-1790 Sentence denotes This article is protected by copyright.
T12 1791-1811 Sentence denotes All rights reserved.
T12 1791-1811 Sentence denotes All rights reserved.