| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-82 |
Sentence |
denotes |
Cytokine Release Syndrome in COVID-19 Patients, A New Scenario for an Old Concern: |
| T1 |
0-82 |
Sentence |
denotes |
Cytokine Release Syndrome in COVID-19 Patients, A New Scenario for an Old Concern: |
| T2 |
83-139 |
Sentence |
denotes |
The Fragile Balance between Infections and Autoimmunity. |
| T2 |
83-139 |
Sentence |
denotes |
The Fragile Balance between Infections and Autoimmunity. |
| T3 |
140-353 |
Sentence |
denotes |
On 7 January 2020, researchers isolated and sequenced in China from patients with severe pneumonitis a novel coronavirus, then called SARS-CoV-2, which rapidly spread worldwide, becoming a global health emergency. |
| T3 |
140-353 |
Sentence |
denotes |
On 7 January 2020, researchers isolated and sequenced in China from patients with severe pneumonitis a novel coronavirus, then called SARS-CoV-2, which rapidly spread worldwide, becoming a global health emergency. |
| T4 |
354-449 |
Sentence |
denotes |
Typical manifestations consist of flu-like symptoms such as fever, cough, fatigue, and dyspnea. |
| T4 |
354-449 |
Sentence |
denotes |
Typical manifestations consist of flu-like symptoms such as fever, cough, fatigue, and dyspnea. |
| T5 |
450-675 |
Sentence |
denotes |
However, in about 20% of patients, the infection progresses to severe interstitial pneumonia and can induce an uncontrolled host-immune response, leading to a life-threatening condition called cytokine release syndrome (CRS). |
| T5 |
450-675 |
Sentence |
denotes |
However, in about 20% of patients, the infection progresses to severe interstitial pneumonia and can induce an uncontrolled host-immune response, leading to a life-threatening condition called cytokine release syndrome (CRS). |
| T6 |
676-815 |
Sentence |
denotes |
CRS represents an emergency scenario of a frequent challenge, which is the complex and interwoven link between infections and autoimmunity. |
| T6 |
676-815 |
Sentence |
denotes |
CRS represents an emergency scenario of a frequent challenge, which is the complex and interwoven link between infections and autoimmunity. |
| T7 |
816-1003 |
Sentence |
denotes |
Indeed, treatment of CRS involves the use of both antivirals to control the underlying infection and immunosuppressive agents to dampen the aberrant pro-inflammatory response of the host. |
| T7 |
816-1003 |
Sentence |
denotes |
Indeed, treatment of CRS involves the use of both antivirals to control the underlying infection and immunosuppressive agents to dampen the aberrant pro-inflammatory response of the host. |
| T8 |
1004-1212 |
Sentence |
denotes |
Several trials, evaluating the safety and effectiveness of immunosuppressants commonly used in rheumatic diseases, are ongoing in patients with COVID-19 and CRS, some of which are achieving promising results. |
| T8 |
1004-1212 |
Sentence |
denotes |
Several trials, evaluating the safety and effectiveness of immunosuppressants commonly used in rheumatic diseases, are ongoing in patients with COVID-19 and CRS, some of which are achieving promising results. |
| T9 |
1213-1434 |
Sentence |
denotes |
However, such a use should follow a multidisciplinary approach, be accompanied by close monitoring, be tailored to patient's clinical and serological features, and be initiated at the right time to reach the best results. |
| T9 |
1213-1434 |
Sentence |
denotes |
However, such a use should follow a multidisciplinary approach, be accompanied by close monitoring, be tailored to patient's clinical and serological features, and be initiated at the right time to reach the best results. |
| T10 |
1435-1659 |
Sentence |
denotes |
Autoimmune patients receiving immunosuppressants could be prone to SARS-CoV-2 infections; however, suspension of the ongoing therapy is contraindicated to avoid disease flares and a consequent increase in the infection risk. |
| T10 |
1435-1659 |
Sentence |
denotes |
Autoimmune patients receiving immunosuppressants could be prone to SARS-CoV-2 infections; however, suspension of the ongoing therapy is contraindicated to avoid disease flares and a consequent increase in the infection risk. |