> top > projects > Inflammaging > docs > PubMed:32052831 > annotations
Inflammaging  

PubMed:32052831 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-148 Sentence denotes A Randomized Controlled Trial of Ceftriaxone and Doxycycline, With or Without Metronidazole, for the Treatment of Acute Pelvic Inflammatory Disease.
T1 0-148 Sentence denotes A Randomized Controlled Trial of Ceftriaxone and Doxycycline, With or Without Metronidazole, for the Treatment of Acute Pelvic Inflammatory Disease.
T2 149-160 Sentence denotes BACKGROUND:
T2 149-160 Sentence denotes BACKGROUND:
T3 161-248 Sentence denotes Anaerobic organisms are important pathogens in acute pelvic inflammatory disease (PID).
T3 161-248 Sentence denotes Anaerobic organisms are important pathogens in acute pelvic inflammatory disease (PID).
T4 249-378 Sentence denotes The currently recommended PID regimen of a single dose of ceftriaxone and doxycycline for 14 days has limited anaerobic activity.
T4 249-378 Sentence denotes The currently recommended PID regimen of a single dose of ceftriaxone and doxycycline for 14 days has limited anaerobic activity.
T5 379-493 Sentence denotes The need for broader anaerobic coverage is unknown and concerns have been raised about metronidazole tolerability.
T5 379-493 Sentence denotes The need for broader anaerobic coverage is unknown and concerns have been raised about metronidazole tolerability.
T6 494-502 Sentence denotes METHODS:
T6 494-502 Sentence denotes METHODS:
T7 503-718 Sentence denotes We conducted a randomized, double-blind, placebo-controlled trial comparing ceftriaxone 250 mg intramuscular single dose and doxycycline for 14 days, with or without 14 days of metronidazole in women with acute PID.
T7 503-718 Sentence denotes We conducted a randomized, double-blind, placebo-controlled trial comparing ceftriaxone 250 mg intramuscular single dose and doxycycline for 14 days, with or without 14 days of metronidazole in women with acute PID.
T8 719-795 Sentence denotes The primary outcome was clinical improvement at 3 days following enrollment.
T8 719-795 Sentence denotes The primary outcome was clinical improvement at 3 days following enrollment.
T9 796-998 Sentence denotes Additional outcomes at 30 days following treatment were the presence of anaerobic organisms in the endometrium, clinical cure (absence of fever and reduction in tenderness), adherence, and tolerability.
T9 796-998 Sentence denotes Additional outcomes at 30 days following treatment were the presence of anaerobic organisms in the endometrium, clinical cure (absence of fever and reduction in tenderness), adherence, and tolerability.
T10 999-1007 Sentence denotes RESULTS:
T10 999-1007 Sentence denotes RESULTS:
T11 1008-1072 Sentence denotes We enrolled 233 women (116 to metronidazole and 117 to placebo).
T11 1008-1072 Sentence denotes We enrolled 233 women (116 to metronidazole and 117 to placebo).
T12 1073-1137 Sentence denotes Clinical improvement at 3 days was similar between the 2 groups.
T12 1073-1137 Sentence denotes Clinical improvement at 3 days was similar between the 2 groups.
T13 1138-1380 Sentence denotes At 30 days following treatment, anaerobic organisms were less frequently recovered from the endometrium in women treated with metronidazole than placebo (8% vs 21%, P < .05) and cervical Mycoplasma genitalium was reduced (4% vs 14%, P < .05).
T13 1138-1380 Sentence denotes At 30 days following treatment, anaerobic organisms were less frequently recovered from the endometrium in women treated with metronidazole than placebo (8% vs 21%, P < .05) and cervical Mycoplasma genitalium was reduced (4% vs 14%, P < .05).
T14 1381-1477 Sentence denotes Pelvic tenderness was also less common among women receiving metronidazole (9% vs 20%, P < .05).
T14 1381-1477 Sentence denotes Pelvic tenderness was also less common among women receiving metronidazole (9% vs 20%, P < .05).
T15 1478-1544 Sentence denotes Adverse events and adherence were similar in each treatment group.
T15 1478-1544 Sentence denotes Adverse events and adherence were similar in each treatment group.
T16 1545-1557 Sentence denotes CONCLUSIONS:
T16 1545-1557 Sentence denotes CONCLUSIONS:
T17 1558-1812 Sentence denotes In women treated for acute PID, the addition of metronidazole to ceftriaxone and doxycycline was well tolerated and resulted in reduced endometrial anaerobes, decreased M. genitalium, and reduced pelvic tenderness compared to ceftriaxone and doxycycline.
T17 1558-1812 Sentence denotes In women treated for acute PID, the addition of metronidazole to ceftriaxone and doxycycline was well tolerated and resulted in reduced endometrial anaerobes, decreased M. genitalium, and reduced pelvic tenderness compared to ceftriaxone and doxycycline.
T18 1813-1926 Sentence denotes Metronidazole should be routinely added to ceftriaxone and doxycycline for the treatment of women with acute PID.
T18 1813-1926 Sentence denotes Metronidazole should be routinely added to ceftriaxone and doxycycline for the treatment of women with acute PID.
T19 1927-1969 Sentence denotes CLINICAL TRIALS REGISTRATION: NCT01160640.
T19 1927-1969 Sentence denotes CLINICAL TRIALS REGISTRATION: NCT01160640.