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PubMed:31656084 JSONTXT

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Id Subject Object Predicate Lexical cue
T1 0-201 Sentence denotes Ascorbic Acid 2-Glucoside Stably Promotes the Primitiveness of Embryonic and Mesenchymal Stem Cells Through Ten-Eleven Translocation- and cAMP-Responsive Element-Binding Protein-1-Dependent Mechanisms.
T1 0-201 Sentence denotes Ascorbic Acid 2-Glucoside Stably Promotes the Primitiveness of Embryonic and Mesenchymal Stem Cells Through Ten-Eleven Translocation- and cAMP-Responsive Element-Binding Protein-1-Dependent Mechanisms.
T2 202-207 Sentence denotes Aims:
T2 202-207 Sentence denotes Aims:
T3 208-334 Sentence denotes The naive or primitive states of stem cells (SCs) residing in specific niches are unstable and difficult to preserve in vitro.
T3 208-334 Sentence denotes The naive or primitive states of stem cells (SCs) residing in specific niches are unstable and difficult to preserve in vitro.
T4 335-462 Sentence denotes Vitamin C (VitC), in addition to suppressing oxygen radicals, exerts pleiotropic effects to preserve the core functions of SCs.
T4 335-462 Sentence denotes Vitamin C (VitC), in addition to suppressing oxygen radicals, exerts pleiotropic effects to preserve the core functions of SCs.
T5 463-605 Sentence denotes However, this compound is labile and readily oxidized, resulting in cellular toxicity and preventing its reliable application in this context.
T5 463-605 Sentence denotes However, this compound is labile and readily oxidized, resulting in cellular toxicity and preventing its reliable application in this context.
T6 606-826 Sentence denotes We found that a VitC derivative, ascorbic acid 2-glucoside (AA2G), stably maintains the naive pluripotency of murine embryonic SCs (mESCs) and the primitiveness of human mesenchymal SCs (hMSCs) without cellular toxicity.
T6 606-826 Sentence denotes We found that a VitC derivative, ascorbic acid 2-glucoside (AA2G), stably maintains the naive pluripotency of murine embryonic SCs (mESCs) and the primitiveness of human mesenchymal SCs (hMSCs) without cellular toxicity.
T7 827-835 Sentence denotes Results:
T7 827-835 Sentence denotes Results:
T8 836-968 Sentence denotes The beneficial effects of AA2G and related molecular mechanisms were evaluated in mESCs, induced pluripotent-SCs (iPSCs), and hMSCs.
T8 836-968 Sentence denotes The beneficial effects of AA2G and related molecular mechanisms were evaluated in mESCs, induced pluripotent-SCs (iPSCs), and hMSCs.
T9 969-1071 Sentence denotes AA2G was stable in aqueous solution and barely induced cellular toxicity in cultured SCs, unlike VitC.
T9 969-1071 Sentence denotes AA2G was stable in aqueous solution and barely induced cellular toxicity in cultured SCs, unlike VitC.
T10 1072-1281 Sentence denotes AA2G supplementation recapitulated the well-known effects of VitC, including induction of ten-eleven translocation-dependent DNA demethylation in mESCs and suppression of p53 during generation of murine iPSCs.
T10 1072-1281 Sentence denotes AA2G supplementation recapitulated the well-known effects of VitC, including induction of ten-eleven translocation-dependent DNA demethylation in mESCs and suppression of p53 during generation of murine iPSCs.
T11 1282-1464 Sentence denotes Furthermore, supplementation of hMSCs with AA2G improved therapeutic outcomes in an asthma mouse model by promoting their self-renewal, engraftment, and anti-inflammatory properties.
T11 1282-1464 Sentence denotes Furthermore, supplementation of hMSCs with AA2G improved therapeutic outcomes in an asthma mouse model by promoting their self-renewal, engraftment, and anti-inflammatory properties.
T12 1465-1657 Sentence denotes Particularly, activation of the cAMP-responsive element-binding protein-1 (CREB1) pathway contributed to the ability of AA2G to maintain naive pluripotency of mESCs and functionality of hMSCs.
T12 1465-1657 Sentence denotes Particularly, activation of the cAMP-responsive element-binding protein-1 (CREB1) pathway contributed to the ability of AA2G to maintain naive pluripotency of mESCs and functionality of hMSCs.
T13 1658-1684 Sentence denotes Innovation and Conclusion:
T13 1658-1684 Sentence denotes Innovation and Conclusion:
T14 1685-1912 Sentence denotes Given its long-lasting effects and low cellular toxicity, AA2G supplementation is useful to support the naive pluripotency of mESCs and the primitiveness of hMSCs, affecting their developmental potency and therapeutic efficacy.
T14 1685-1912 Sentence denotes Given its long-lasting effects and low cellular toxicity, AA2G supplementation is useful to support the naive pluripotency of mESCs and the primitiveness of hMSCs, affecting their developmental potency and therapeutic efficacy.
T15 1913-2014 Sentence denotes Furthermore, we demonstrate the significance of the CREB1 pathway in the mechanism of action of AA2G.
T15 1913-2014 Sentence denotes Furthermore, we demonstrate the significance of the CREB1 pathway in the mechanism of action of AA2G.