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Id Subject Object Predicate Lexical cue
T1 0-171 Sentence denotes The renal protection of flavonoid-rich ethanolic extract from silkworm green cocoon involves in inhibiting TNF-α-p38 MAP kinase signalling pathway in type 2 diabetic mice.
T1 0-171 Sentence denotes The renal protection of flavonoid-rich ethanolic extract from silkworm green cocoon involves in inhibiting TNF-α-p38 MAP kinase signalling pathway in type 2 diabetic mice.
T2 172-183 Sentence denotes BACKGROUND:
T2 172-183 Sentence denotes BACKGROUND:
T3 184-256 Sentence denotes Diabetic nephropathy (DN) is one of the major complications of diabetes.
T3 184-256 Sentence denotes Diabetic nephropathy (DN) is one of the major complications of diabetes.
T4 257-396 Sentence denotes Sericin and flavonoids are two bioactive substances which have been demonstrated to have some therapeutical effect on diabetic nephropathy.
T4 257-396 Sentence denotes Sericin and flavonoids are two bioactive substances which have been demonstrated to have some therapeutical effect on diabetic nephropathy.
T5 397-655 Sentence denotes The aim of this paper is to investigate the effect of ethanolic extract (EE) rich in quercetin and kaempferol and their glucosides from the green cocoon of silkworm Bombyx mori on DN in type 2 diabetic (T2D) mice induced by high-fat and streptozotocin (STZ).
T5 397-655 Sentence denotes The aim of this paper is to investigate the effect of ethanolic extract (EE) rich in quercetin and kaempferol and their glucosides from the green cocoon of silkworm Bombyx mori on DN in type 2 diabetic (T2D) mice induced by high-fat and streptozotocin (STZ).
T6 656-664 Sentence denotes METHODS:
T6 656-664 Sentence denotes METHODS:
T7 665-756 Sentence denotes Ethanolic extract from the green cocoon shell of silkworm Bombyx mori was used as material.
T7 665-756 Sentence denotes Ethanolic extract from the green cocoon shell of silkworm Bombyx mori was used as material.
T8 757-947 Sentence denotes Diabetic mice were orally treated with three doses (150, 250 and 350 mg/kg) of the extract for 7 weeks, then the levels of oxidases and related inflammatory factors were measured in kidneys.
T8 757-947 Sentence denotes Diabetic mice were orally treated with three doses (150, 250 and 350 mg/kg) of the extract for 7 weeks, then the levels of oxidases and related inflammatory factors were measured in kidneys.
T9 948-956 Sentence denotes RESULTS:
T9 948-956 Sentence denotes RESULTS:
T10 957-1123 Sentence denotes Compared with the negative control, EE administration resulted in an evident reduction in blood glucose levels and an improvement of the body weight in diabetic mice.
T10 957-1123 Sentence denotes Compared with the negative control, EE administration resulted in an evident reduction in blood glucose levels and an improvement of the body weight in diabetic mice.
T11 1124-1326 Sentence denotes Oral EE could inhibit the expressions of renal tumour necrosis factor TNF-α, monocyte chemoattractant protein-1 (MCP-1), fibronectin (FN) and P38 mitogen-activated protein kinase (p38 MAPK) in T2D mice.
T11 1124-1326 Sentence denotes Oral EE could inhibit the expressions of renal tumour necrosis factor TNF-α, monocyte chemoattractant protein-1 (MCP-1), fibronectin (FN) and P38 mitogen-activated protein kinase (p38 MAPK) in T2D mice.
T12 1327-1470 Sentence denotes Moreover, the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) were significantly elevated in T2D mice treated with EE.
T12 1327-1470 Sentence denotes Moreover, the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) were significantly elevated in T2D mice treated with EE.
T13 1471-1483 Sentence denotes CONCLUSIONS:
T13 1471-1483 Sentence denotes CONCLUSIONS:
T14 1484-1701 Sentence denotes The activities of anti-fibrosis and anti-inflammation contributed to the renal protective effects by reducing oxidative stress, which might be mediated by the inhibition of the TNF-α-p38 MAP kinase signalling pathway.
T14 1484-1701 Sentence denotes The activities of anti-fibrosis and anti-inflammation contributed to the renal protective effects by reducing oxidative stress, which might be mediated by the inhibition of the TNF-α-p38 MAP kinase signalling pathway.
T15 1702-1820 Sentence denotes It is suggested that the ethanolic extract from silkworm green cocoon might be potential as an herbal medicine for DN.
T15 1702-1820 Sentence denotes It is suggested that the ethanolic extract from silkworm green cocoon might be potential as an herbal medicine for DN.