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PubMed:31520422 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-127 Sentence denotes microRNA-218-5p plays a protective role in eosinophilic airway inflammation via targeting δ-catenin, a novel catenin in asthma.
T1 0-127 Sentence denotes microRNA-218-5p plays a protective role in eosinophilic airway inflammation via targeting δ-catenin, a novel catenin in asthma.
T2 128-221 Sentence denotes BACKGROUND: microRNA (miR)-218-5p is involved in cigarette smoke-induced airway inflammation.
T2 128-221 Sentence denotes BACKGROUND: microRNA (miR)-218-5p is involved in cigarette smoke-induced airway inflammation.
T3 222-323 Sentence denotes In our earlier asthma epithelial miRNA profiling data, miR-218-5p was the top 2 down-regulated miRNA.
T3 222-323 Sentence denotes In our earlier asthma epithelial miRNA profiling data, miR-218-5p was the top 2 down-regulated miRNA.
T4 324-398 Sentence denotes We hypothesize that miR-218-5p plays a role in asthma airway inflammation.
T4 324-398 Sentence denotes We hypothesize that miR-218-5p plays a role in asthma airway inflammation.
T5 399-409 Sentence denotes OBJECTIVE:
T5 399-409 Sentence denotes OBJECTIVE:
T6 410-493 Sentence denotes To unveil the role of miR-218-5p and its target gene in asthma airway inflammation.
T6 410-493 Sentence denotes To unveil the role of miR-218-5p and its target gene in asthma airway inflammation.
T7 494-502 Sentence denotes METHODS:
T7 494-502 Sentence denotes METHODS:
T8 503-703 Sentence denotes We measured miR-218-5p expression in bronchial brushings of asthma patients (n = 50) and healthy controls (n = 15), and analysed the correlations between miR-218-5p expression and airway eosinophilia.
T8 503-703 Sentence denotes We measured miR-218-5p expression in bronchial brushings of asthma patients (n = 50) and healthy controls (n = 15), and analysed the correlations between miR-218-5p expression and airway eosinophilia.
T9 704-900 Sentence denotes We examined whether CTNND2 was a target of miR-218-5p, and the expression of 12 catenin family members in bronchial brushings, in cultured human bronchial epithelial (HBE) cells and BEAS-2B cells.
T9 704-900 Sentence denotes We examined whether CTNND2 was a target of miR-218-5p, and the expression of 12 catenin family members in bronchial brushings, in cultured human bronchial epithelial (HBE) cells and BEAS-2B cells.
T10 901-1004 Sentence denotes We explored the role of miR-218-5p-CTNND2 pathway using a murine model of allergic airway inflammation.
T10 901-1004 Sentence denotes We explored the role of miR-218-5p-CTNND2 pathway using a murine model of allergic airway inflammation.
T11 1005-1013 Sentence denotes RESULTS:
T11 1005-1013 Sentence denotes RESULTS:
T12 1014-1207 Sentence denotes Epithelial miR-218-5p expression was significantly decreased and negatively correlated with eosinophils in induced sputum and bronchial biopsies, and other type 2 biomarkers in asthma patients.
T12 1014-1207 Sentence denotes Epithelial miR-218-5p expression was significantly decreased and negatively correlated with eosinophils in induced sputum and bronchial biopsies, and other type 2 biomarkers in asthma patients.
T13 1208-1280 Sentence denotes We verified that CTNND2 (encoding δ-catenin) was a target of miR-218-5p.
T13 1208-1280 Sentence denotes We verified that CTNND2 (encoding δ-catenin) was a target of miR-218-5p.
T14 1281-1480 Sentence denotes Remarkably, CTNND2 was the most significantly up-regulated catenin compared with the other 11 catenin family members in bronchial brushings of asthma patients, IL-13-stimulated HBE and BEAS-2B cells.
T14 1281-1480 Sentence denotes Remarkably, CTNND2 was the most significantly up-regulated catenin compared with the other 11 catenin family members in bronchial brushings of asthma patients, IL-13-stimulated HBE and BEAS-2B cells.
T15 1481-1577 Sentence denotes Moreover, epithelial CTNND2 expression positively correlated with airway eosinophilia in asthma.
T15 1481-1577 Sentence denotes Moreover, epithelial CTNND2 expression positively correlated with airway eosinophilia in asthma.
T16 1578-1717 Sentence denotes Airway mmu-miR-218-5p expression was also decreased, and Ctnnd2 expression was increased in a murine model of allergic airway inflammation.
T16 1578-1717 Sentence denotes Airway mmu-miR-218-5p expression was also decreased, and Ctnnd2 expression was increased in a murine model of allergic airway inflammation.
T17 1718-1878 Sentence denotes Intriguingly, mmu-miR-218-5p overexpression suppressed airway hyperresponsiveness, eosinophilic airway inflammation and Ctnnd2 up-regulation in the mouse model.
T17 1718-1878 Sentence denotes Intriguingly, mmu-miR-218-5p overexpression suppressed airway hyperresponsiveness, eosinophilic airway inflammation and Ctnnd2 up-regulation in the mouse model.
T18 1879-2026 Sentence denotes Finally, perturbation of miR-218-5p or CTNND2 expression significantly altered chemokine CCL26 expression in the cell cultures and the mouse model.
T18 1879-2026 Sentence denotes Finally, perturbation of miR-218-5p or CTNND2 expression significantly altered chemokine CCL26 expression in the cell cultures and the mouse model.
T19 2027-2062 Sentence denotes CONCLUSIONS AND CLINICAL RELEVANCE:
T19 2027-2062 Sentence denotes CONCLUSIONS AND CLINICAL RELEVANCE:
T20 2063-2237 Sentence denotes Epithelial miR-218-5p plays a protective role in eosinophilic airway inflammation via targeting CTNND2, a novel catenin in asthma, and suppressing chemokine CCL26 expression.
T20 2063-2237 Sentence denotes Epithelial miR-218-5p plays a protective role in eosinophilic airway inflammation via targeting CTNND2, a novel catenin in asthma, and suppressing chemokine CCL26 expression.