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PubMed:31110314 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-60 Sentence denotes CD8+ T cells induce cachexia during chronic viral infection.
T1 0-60 Sentence denotes CD8+ T cells induce cachexia during chronic viral infection.
T2 61-180 Sentence denotes Cachexia represents a leading cause of morbidity and mortality in various cancers, chronic inflammation and infections.
T2 61-180 Sentence denotes Cachexia represents a leading cause of morbidity and mortality in various cancers, chronic inflammation and infections.
T3 181-306 Sentence denotes Understanding of the mechanisms that drive cachexia has remained limited, especially for infection-associated cachexia (IAC).
T3 181-306 Sentence denotes Understanding of the mechanisms that drive cachexia has remained limited, especially for infection-associated cachexia (IAC).
T4 307-463 Sentence denotes In the present paper we describe a model of reversible cachexia in mice with chronic viral infection and identify an essential role for CD8+ T cells in IAC.
T4 307-463 Sentence denotes In the present paper we describe a model of reversible cachexia in mice with chronic viral infection and identify an essential role for CD8+ T cells in IAC.
T5 464-537 Sentence denotes Cytokines linked to cancer-associated cachexia did not contribute to IAC.
T5 464-537 Sentence denotes Cytokines linked to cancer-associated cachexia did not contribute to IAC.
T6 538-678 Sentence denotes Instead, virus-specific CD8+ T cells caused morphologic and molecular changes in the adipose tissue, which led to depletion of lipid stores.
T6 538-678 Sentence denotes Instead, virus-specific CD8+ T cells caused morphologic and molecular changes in the adipose tissue, which led to depletion of lipid stores.
T7 679-856 Sentence denotes These changes occurred at a time point that preceded the peak of the CD8+ T cell response and required T cell-intrinsic type I interferon signaling and antigen-specific priming.
T7 679-856 Sentence denotes These changes occurred at a time point that preceded the peak of the CD8+ T cell response and required T cell-intrinsic type I interferon signaling and antigen-specific priming.
T8 857-998 Sentence denotes Our results link systemic antiviral immune responses to adipose-tissue remodeling and reveal an underappreciated role of CD8+ T cells in IAC.
T8 857-998 Sentence denotes Our results link systemic antiviral immune responses to adipose-tissue remodeling and reveal an underappreciated role of CD8+ T cells in IAC.