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PubMed:31072570 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-95 Sentence denotes Myofibroblast Phenotype and Reversibility of Fibrosis in Patients With End-Stage Heart Failure.
T1 0-95 Sentence denotes Myofibroblast Phenotype and Reversibility of Fibrosis in Patients With End-Stage Heart Failure.
T2 96-107 Sentence denotes BACKGROUND:
T2 96-107 Sentence denotes BACKGROUND:
T3 108-307 Sentence denotes Interstitial fibrosis is an important component of diastolic, and systolic, dysfunction in heart failure (HF) and depends on activation and differentiation of fibroblasts into myofibroblasts (MyoFb).
T3 108-307 Sentence denotes Interstitial fibrosis is an important component of diastolic, and systolic, dysfunction in heart failure (HF) and depends on activation and differentiation of fibroblasts into myofibroblasts (MyoFb).
T4 308-392 Sentence denotes Recent clinical evidence suggests that in late-stage HF, fibrosis is not reversible.
T4 308-392 Sentence denotes Recent clinical evidence suggests that in late-stage HF, fibrosis is not reversible.
T5 393-404 Sentence denotes OBJECTIVES:
T5 393-404 Sentence denotes OBJECTIVES:
T6 405-547 Sentence denotes The study aims to examine the degree of differentiation of cardiac MyoFb in end-stage HF and the potential for their phenotypic reversibility.
T6 405-547 Sentence denotes The study aims to examine the degree of differentiation of cardiac MyoFb in end-stage HF and the potential for their phenotypic reversibility.
T7 548-556 Sentence denotes METHODS:
T7 548-556 Sentence denotes METHODS:
T8 557-725 Sentence denotes Fibroblasts were isolated from the left ventricle of the explanted hearts of transplant recipients (ischemic and dilated cardiomyopathy), and from nonused donor hearts.
T8 557-725 Sentence denotes Fibroblasts were isolated from the left ventricle of the explanted hearts of transplant recipients (ischemic and dilated cardiomyopathy), and from nonused donor hearts.
T9 726-819 Sentence denotes Fibroblasts were maintained in culture without passaging for 4 or 8 days (treatment studies).
T9 726-819 Sentence denotes Fibroblasts were maintained in culture without passaging for 4 or 8 days (treatment studies).
T10 820-931 Sentence denotes Phenotyping included functional testing, immunostaining, and expression studies for markers of differentiation.
T10 820-931 Sentence denotes Phenotyping included functional testing, immunostaining, and expression studies for markers of differentiation.
T11 932-1023 Sentence denotes These data were complemented with immunohistology and expression studies in tissue samples.
T11 932-1023 Sentence denotes These data were complemented with immunohistology and expression studies in tissue samples.
T12 1024-1032 Sentence denotes RESULTS:
T12 1024-1032 Sentence denotes RESULTS:
T13 1033-1143 Sentence denotes Interstitial fibrosis with cross-linked collagen is prominent in HF hearts, with presence of activated MyoFbs.
T13 1033-1143 Sentence denotes Interstitial fibrosis with cross-linked collagen is prominent in HF hearts, with presence of activated MyoFbs.
T14 1144-1253 Sentence denotes Tissue levels of transforming growth factor (TGF)-β1, lysyl oxidase, periostin, and osteopontin are elevated.
T14 1144-1253 Sentence denotes Tissue levels of transforming growth factor (TGF)-β1, lysyl oxidase, periostin, and osteopontin are elevated.
T15 1254-1405 Sentence denotes Fibroblastic cells isolated from HF hearts are predominantly MyoFb, proliferative or nonproliferative, with mature α-smooth muscle actin stress fibers.
T15 1254-1405 Sentence denotes Fibroblastic cells isolated from HF hearts are predominantly MyoFb, proliferative or nonproliferative, with mature α-smooth muscle actin stress fibers.
T16 1406-1496 Sentence denotes HF MyoFb express high levels of profibrotic cytokines and the TGF-β1 pathway is activated.
T16 1406-1496 Sentence denotes HF MyoFb express high levels of profibrotic cytokines and the TGF-β1 pathway is activated.
T17 1497-1742 Sentence denotes Inhibition of TGF-β1 receptor kinase in HF MyoFb promotes dedifferentiation of MyoFb with loss of α-smooth muscle actin and depolymerization of stress fibers, and reduces the expression of profibrotic genes and cytokines levels to non-HF levels.
T17 1497-1742 Sentence denotes Inhibition of TGF-β1 receptor kinase in HF MyoFb promotes dedifferentiation of MyoFb with loss of α-smooth muscle actin and depolymerization of stress fibers, and reduces the expression of profibrotic genes and cytokines levels to non-HF levels.
T18 1743-1754 Sentence denotes CONCLUSION:
T18 1743-1754 Sentence denotes CONCLUSION:
T19 1755-1957 Sentence denotes MyoFb in end-stage HF have a variable degree of differentiation and retain the capacity to return to a less activated state, validating the potential for developing antifibrotic therapy targeting MyoFb.
T19 1755-1957 Sentence denotes MyoFb in end-stage HF have a variable degree of differentiation and retain the capacity to return to a less activated state, validating the potential for developing antifibrotic therapy targeting MyoFb.