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Id Subject Object Predicate Lexical cue
T1 0-104 Sentence denotes More advantages in detecting bone and soft tissue metastases from prostate cancer using 18F-PSMA PET/CT.
T1 0-104 Sentence denotes More advantages in detecting bone and soft tissue metastases from prostate cancer using 18F-PSMA PET/CT.
T2 105-183 Sentence denotes Prostate cancer (PCa) is the most common solid cancer affecting men worldwide.
T2 105-183 Sentence denotes Prostate cancer (PCa) is the most common solid cancer affecting men worldwide.
T3 184-363 Sentence denotes Serum prostate-specific antigen (PSA) is at present the most commonly used biomarker for PCa screening, as well as a reliable marker of disease recurrence after initial treatment.
T3 184-363 Sentence denotes Serum prostate-specific antigen (PSA) is at present the most commonly used biomarker for PCa screening, as well as a reliable marker of disease recurrence after initial treatment.
T4 364-431 Sentence denotes Bone metastases (BM) are present in advanced stages of the disease.
T4 364-431 Sentence denotes Bone metastases (BM) are present in advanced stages of the disease.
T5 432-612 Sentence denotes Imaging of BM is important not only for localization and characterization, but also to evaluate their size and number, as well as to follow-up the disease during and after therapy.
T5 432-612 Sentence denotes Imaging of BM is important not only for localization and characterization, but also to evaluate their size and number, as well as to follow-up the disease during and after therapy.
T6 613-758 Sentence denotes Bone metastases formation is triggered by cancer initiating cells in the bone marrow and is facilitated by the release of several growth factors.
T6 613-758 Sentence denotes Bone metastases formation is triggered by cancer initiating cells in the bone marrow and is facilitated by the release of several growth factors.
T7 759-905 Sentence denotes Although BM from PCa are very heterogenic, the majority of them are described as "osteoblastic", while pure "osteolytic" metastases are very rare.
T7 759-905 Sentence denotes Although BM from PCa are very heterogenic, the majority of them are described as "osteoblastic", while pure "osteolytic" metastases are very rare.
T8 906-987 Sentence denotes The PSA levels, along with other parameters, may determine the risk of having BM.
T8 906-987 Sentence denotes The PSA levels, along with other parameters, may determine the risk of having BM.
T9 988-1337 Sentence denotes A classification report, which is currently in use, divides patients into three categories according to the risk of having BM: low risk (PSA<10ng/mL, clinical stage T1-T2a, Gleason Score ≤6), intermediate risk (PSA 10.1-20ng/mL, clinical stage T2b-T2c, Gleason Score=7) and high risk (PSA>20ng/mL, clinical stage T3a or higher, or Gleason Score ≥8).
T9 988-1337 Sentence denotes A classification report, which is currently in use, divides patients into three categories according to the risk of having BM: low risk (PSA<10ng/mL, clinical stage T1-T2a, Gleason Score ≤6), intermediate risk (PSA 10.1-20ng/mL, clinical stage T2b-T2c, Gleason Score=7) and high risk (PSA>20ng/mL, clinical stage T3a or higher, or Gleason Score ≥8).
T10 1338-1558 Sentence denotes Even though PSA remains the only biomarker of this disease in clinical practice, it is not always analogue with the severity of the disease and should be evaluated along with the clinical and diagnostic imaging findings.
T10 1338-1558 Sentence denotes Even though PSA remains the only biomarker of this disease in clinical practice, it is not always analogue with the severity of the disease and should be evaluated along with the clinical and diagnostic imaging findings.
T11 1559-1650 Sentence denotes Detection of BM is not always easy, as there may be unexpected sites and occult metastases.
T11 1559-1650 Sentence denotes Detection of BM is not always easy, as there may be unexpected sites and occult metastases.
T12 1651-1839 Sentence denotes The clinical importance of revealing BM in patients with PCa is to determine the overall survival of the patients and their quality of life, as BM may lead to high morbidity and mortality.
T12 1651-1839 Sentence denotes The clinical importance of revealing BM in patients with PCa is to determine the overall survival of the patients and their quality of life, as BM may lead to high morbidity and mortality.
T13 1840-2040 Sentence denotes There are many options of treating BM, such as chemotherapy, immunotherapy, external beam radiotherapy, bone modifying agents and recently prostate-specific membrane antigen (PSMA) targeted therapies.
T13 1840-2040 Sentence denotes There are many options of treating BM, such as chemotherapy, immunotherapy, external beam radiotherapy, bone modifying agents and recently prostate-specific membrane antigen (PSMA) targeted therapies.
T14 2041-2144 Sentence denotes Another potential therapy is radioguided surgery, in patients with occult and/or focally recurrent PCa.
T14 2041-2144 Sentence denotes Another potential therapy is radioguided surgery, in patients with occult and/or focally recurrent PCa.
T15 2145-2279 Sentence denotes Such a single occult metastasis causing very high levels of PSA has been presented using technetium-99m (99m Tc) labeled PSMA imaging.
T15 2145-2279 Sentence denotes Such a single occult metastasis causing very high levels of PSA has been presented using technetium-99m (99m Tc) labeled PSMA imaging.
T16 2280-2515 Sentence denotes Diagnosis and staging of PCa mostly relies on the morphology of imaging, using computerized tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography/CT (PET/CT) using fluorine-18-fluorodeoxyglucose (18 F-FDG).
T16 2280-2515 Sentence denotes Diagnosis and staging of PCa mostly relies on the morphology of imaging, using computerized tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography/CT (PET/CT) using fluorine-18-fluorodeoxyglucose (18 F-FDG).
T17 2516-2806 Sentence denotes The radiopharmaceuticals used in Nuclear Medicine for BM in PCa are: a) those that target lesions, such as 99m Tc-phosphonates, 18 F-sodium fluoride (18 F-NaF) and b) those that target the cancer cells, such as 18 F or carbon-11 (11 C)-choline, 18 F-FDG and 18 F or gallium-68 (68 Ga)-PSMA.
T17 2516-2806 Sentence denotes The radiopharmaceuticals used in Nuclear Medicine for BM in PCa are: a) those that target lesions, such as 99m Tc-phosphonates, 18 F-sodium fluoride (18 F-NaF) and b) those that target the cancer cells, such as 18 F or carbon-11 (11 C)-choline, 18 F-FDG and 18 F or gallium-68 (68 Ga)-PSMA.
T18 2807-2915 Sentence denotes Bone scan with 99mTc-phosphonates is widely used for the evaluation of bone metabolism in patients with PCa.
T18 2807-2915 Sentence denotes Bone scan with 99mTc-phosphonates is widely used for the evaluation of bone metabolism in patients with PCa.
T19 2916-3019 Sentence denotes It is a low cost, widely available radiopharmaceutical having the advantage of a whole body evaluation.
T19 2916-3019 Sentence denotes It is a low cost, widely available radiopharmaceutical having the advantage of a whole body evaluation.
T20 3020-3092 Sentence denotes Planar and single photon emission tomography (SPET) may also be applied.
T20 3020-3092 Sentence denotes Planar and single photon emission tomography (SPET) may also be applied.
T21 3093-3334 Sentence denotes The sensitivity of the whole body scan (WBS) ranges from 75%-95%, while the specificity is lower, ranging from 60%-75% due to false positive findings in benign conditions (arthritis, inflammation etc) who also have increased bone metabolism.
T21 3093-3334 Sentence denotes The sensitivity of the whole body scan (WBS) ranges from 75%-95%, while the specificity is lower, ranging from 60%-75% due to false positive findings in benign conditions (arthritis, inflammation etc) who also have increased bone metabolism.
T22 3335-3459 Sentence denotes Sensitivity and specificity however, perform better (96% and 94% respectively) when SPET and SPET/CT techniques are applied.
T22 3335-3459 Sentence denotes Sensitivity and specificity however, perform better (96% and 94% respectively) when SPET and SPET/CT techniques are applied.
T23 3460-3522 Sentence denotes Of course, bone marrow metastases cannot be detected in a WBS.
T23 3460-3522 Sentence denotes Of course, bone marrow metastases cannot be detected in a WBS.
T24 3523-3779 Sentence denotes The PSA marker is used to predict the pre-test probability of BM and in case of a bone scan several retrospective analyses showed that PSA levels <20ng/mL can exclude with high probability a positive WBS, with a high negative predictive value (almost 99%).
T24 3523-3779 Sentence denotes The PSA marker is used to predict the pre-test probability of BM and in case of a bone scan several retrospective analyses showed that PSA levels <20ng/mL can exclude with high probability a positive WBS, with a high negative predictive value (almost 99%).
T25 3780-3936 Sentence denotes The European Association of Urology (EAU) guidelines state that a bone scan can be omitted in patients with PSA levels <20ng/mL and with a Gleason Score ≤7.
T25 3780-3936 Sentence denotes The European Association of Urology (EAU) guidelines state that a bone scan can be omitted in patients with PSA levels <20ng/mL and with a Gleason Score ≤7.
T26 3937-4170 Sentence denotes Imaging with 18 F-NaF PET/CT is characterized by high and rapid bone uptake, minimal serum protein binding and rapid blood clearance which lead to a fast and high target to background ratio with a short acquisition time (30 minutes).
T26 3937-4170 Sentence denotes Imaging with 18 F-NaF PET/CT is characterized by high and rapid bone uptake, minimal serum protein binding and rapid blood clearance which lead to a fast and high target to background ratio with a short acquisition time (30 minutes).
T27 4171-4264 Sentence denotes Sensitivity and specificity for the detection of BM in high risk PCa patients is almost 100%.
T27 4171-4264 Sentence denotes Sensitivity and specificity for the detection of BM in high risk PCa patients is almost 100%.
T28 4265-4405 Sentence denotes The main advantages provided by 18 F-NaF PET/CT are the better imaging quality along with a whole body acquisition and the fusion technique.
T28 4265-4405 Sentence denotes The main advantages provided by 18 F-NaF PET/CT are the better imaging quality along with a whole body acquisition and the fusion technique.
T29 4406-4515 Sentence denotes Fluorine-18-choline and 11 C-choline PET/CT came to practice lately, reflecting the cell membrane metabolism.
T29 4406-4515 Sentence denotes Fluorine-18-choline and 11 C-choline PET/CT came to practice lately, reflecting the cell membrane metabolism.
T30 4516-4639 Sentence denotes Choline is an essential component of phospholipids and is trapped in the cells after a phosphorylation by a choline kinase.
T30 4516-4639 Sentence denotes Choline is an essential component of phospholipids and is trapped in the cells after a phosphorylation by a choline kinase.
T31 4640-4776 Sentence denotes The sensitivity and specificity of 18 F-choline PET/CT for detecting BM in patients with PCa is reported to be 79% and 97% respectively.
T31 4640-4776 Sentence denotes The sensitivity and specificity of 18 F-choline PET/CT for detecting BM in patients with PCa is reported to be 79% and 97% respectively.
T32 4777-5023 Sentence denotes However, the performance of choline PET/CT seems to be dependent of the levels of the PSA, in cases of biochemical recurrence and reaches about 75%% in those PCa patients with PSA levels >3ng/mL, with a poor performance when the PSA level is low.
T32 4777-5023 Sentence denotes However, the performance of choline PET/CT seems to be dependent of the levels of the PSA, in cases of biochemical recurrence and reaches about 75%% in those PCa patients with PSA levels >3ng/mL, with a poor performance when the PSA level is low.
T33 5024-5148 Sentence denotes Fluorine-18-FDG is the most commonly used radiotracer in PET/CT, however has a little value in staging and restaging of PCa.
T33 5024-5148 Sentence denotes Fluorine-18-FDG is the most commonly used radiotracer in PET/CT, however has a little value in staging and restaging of PCa.
T34 5149-5375 Sentence denotes Because of its low sensitivity 18 F-FDG is trapped in cancer cells through the activation of the glycolytic pathways and in case of BM is an index of increased glucose metabolism in PCa cells rather than in bone lesion per se.
T34 5149-5375 Sentence denotes Because of its low sensitivity 18 F-FDG is trapped in cancer cells through the activation of the glycolytic pathways and in case of BM is an index of increased glucose metabolism in PCa cells rather than in bone lesion per se.
T35 5376-5501 Sentence denotes Osteolytic lesions show more increased metabolic activity than the osteoblastic lesions and are better revealed with 18F-FDG.
T35 5376-5501 Sentence denotes Osteolytic lesions show more increased metabolic activity than the osteoblastic lesions and are better revealed with 18F-FDG.
T36 5502-5651 Sentence denotes Therefore, 18 F-FDG PET/CT is suggested to be performed only in selected patients with PCa, those with most aggressive tumors and high Gleason score.
T36 5502-5651 Sentence denotes Therefore, 18 F-FDG PET/CT is suggested to be performed only in selected patients with PCa, those with most aggressive tumors and high Gleason score.
T37 5652-5741 Sentence denotes Fluorine-18-PSMA PET/CT The need of a more sensitive and specific agent has been evident.
T37 5652-5741 Sentence denotes Fluorine-18-PSMA PET/CT The need of a more sensitive and specific agent has been evident.
T38 5742-5835 Sentence denotes Prostate specific monoclonal antibody (PSMA) is a folate hydrolase cell surface glycoprotein.
T38 5742-5835 Sentence denotes Prostate specific monoclonal antibody (PSMA) is a folate hydrolase cell surface glycoprotein.
T39 5836-6037 Sentence denotes It is mainly expressed in four tissues of the body, including prostate epithelium, the proximal tubules of the kidney, the jejunal brush border of the small intestine and ganglia of the nervous system.
T39 5836-6037 Sentence denotes It is mainly expressed in four tissues of the body, including prostate epithelium, the proximal tubules of the kidney, the jejunal brush border of the small intestine and ganglia of the nervous system.
T40 6038-6140 Sentence denotes So consequently may in some cases be expressed in cancers other than PCa and also in benign processes.
T40 6038-6140 Sentence denotes So consequently may in some cases be expressed in cancers other than PCa and also in benign processes.
T41 6141-6248 Sentence denotes It is localized in the cytoplasm and the apical side of the prostate epithelium that lines prostatic ducts.
T41 6141-6248 Sentence denotes It is localized in the cytoplasm and the apical side of the prostate epithelium that lines prostatic ducts.
T42 6249-6403 Sentence denotes In case of malignant transformation, PSMA is transferred from the cytoplasm to the luminal surface of the prostatic ducts and thus becomes membrane bound.
T42 6249-6403 Sentence denotes In case of malignant transformation, PSMA is transferred from the cytoplasm to the luminal surface of the prostatic ducts and thus becomes membrane bound.
T43 6404-6526 Sentence denotes It has a unique three-parts structure, an external portion, a transmembrane portion and an internal-cytoplasmatic portion.
T43 6404-6526 Sentence denotes It has a unique three-parts structure, an external portion, a transmembrane portion and an internal-cytoplasmatic portion.
T44 6527-6669 Sentence denotes Prostate specific monoclonal antibody is also upregulated and thus overexpressed in most PCa, but weakly expressed in normal prostatic tissue.
T44 6527-6669 Sentence denotes Prostate specific monoclonal antibody is also upregulated and thus overexpressed in most PCa, but weakly expressed in normal prostatic tissue.
T45 6670-6792 Sentence denotes Imaging by PSMA PET/CT has been shown to detect sites of disease recurrence at lower PSA levels than conventional imaging.
T45 6670-6792 Sentence denotes Imaging by PSMA PET/CT has been shown to detect sites of disease recurrence at lower PSA levels than conventional imaging.
T46 6793-6949 Sentence denotes The PSMA overexpression is even present when the cell becomes castrate-resistant and that is the reason why it is the most favorable target for PET imaging.
T46 6793-6949 Sentence denotes The PSMA overexpression is even present when the cell becomes castrate-resistant and that is the reason why it is the most favorable target for PET imaging.
T47 6950-7118 Sentence denotes Prostate cancer expresses 100 to 1000 times more PSMA than normal tissue and is increasing even more in higher grade tumors as well as in increased castrate resistance.
T47 6950-7118 Sentence denotes Prostate cancer expresses 100 to 1000 times more PSMA than normal tissue and is increasing even more in higher grade tumors as well as in increased castrate resistance.
T48 7119-7222 Sentence denotes Therefore, PSMA represents an excellent target for both diagnostic imaging and endoradiotherapy of PCa.
T48 7119-7222 Sentence denotes Therefore, PSMA represents an excellent target for both diagnostic imaging and endoradiotherapy of PCa.
T49 7223-7347 Sentence denotes For diagnostic purposes PSMA ligands, mainly small-molecule inhibitors, are most commonly labeled either with 68 Ga or 18 F.
T49 7223-7347 Sentence denotes For diagnostic purposes PSMA ligands, mainly small-molecule inhibitors, are most commonly labeled either with 68 Ga or 18 F.
T50 7348-7758 Sentence denotes The 18 F-PSMA-1007 (((3S,10S,14S)-1-(4-(((S)-4-carboxy-2-((S)-4-carboxy-2-(6-18 F-fluoronicotinamido) butanamido) methyl phenyl)-3- (naphthalen-2-ylmethyl)-1,4,12-trioxo-2,5,11,13-tetraazahexadecane- 10,14,16-tricarboxylic acid)) seems to be more favorable among other 18 F-PSMA ligands candidate compounds because it demonstrates high labeling yields, better tumor uptake and non-urinary background clearance.
T50 7348-7758 Sentence denotes The 18 F-PSMA-1007 (((3S,10S,14S)-1-(4-(((S)-4-carboxy-2-((S)-4-carboxy-2-(6-18 F-fluoronicotinamido) butanamido) methyl phenyl)-3- (naphthalen-2-ylmethyl)-1,4,12-trioxo-2,5,11,13-tetraazahexadecane- 10,14,16-tricarboxylic acid)) seems to be more favorable among other 18 F-PSMA ligands candidate compounds because it demonstrates high labeling yields, better tumor uptake and non-urinary background clearance.
T51 7759-7908 Sentence denotes On the contrary, 68 Ga-PSMA is rapidly excreted via the urinary tract resulting in intense accumulation in the bladder, thus, obscuring the prostate.
T51 7759-7908 Sentence denotes On the contrary, 68 Ga-PSMA is rapidly excreted via the urinary tract resulting in intense accumulation in the bladder, thus, obscuring the prostate.
T52 7909-8062 Sentence denotes Compared to 68 Ga, 18 F has many advantages such as it is produced in larger amounts, it has a longer half life and a higher physical spatial resolution.
T52 7909-8062 Sentence denotes Compared to 68 Ga, 18 F has many advantages such as it is produced in larger amounts, it has a longer half life and a higher physical spatial resolution.
T53 8063-8320 Sentence denotes The short half-life of 68 Ga relative to 18 F (68 vs. 110 min) makes 68 Ga-PSMA inconvenient for longer transport, so that it is almost mandatory to use local gallium generators, which have a higher cost and lower yields at the end of their first half-life.
T53 8063-8320 Sentence denotes The short half-life of 68 Ga relative to 18 F (68 vs. 110 min) makes 68 Ga-PSMA inconvenient for longer transport, so that it is almost mandatory to use local gallium generators, which have a higher cost and lower yields at the end of their first half-life.
T54 8321-8468 Sentence denotes Each generator provides only one or two elutions per day and it requires separate syntheses at different times of the day in a local radiopharmacy.
T54 8321-8468 Sentence denotes Each generator provides only one or two elutions per day and it requires separate syntheses at different times of the day in a local radiopharmacy.
T55 8469-8578 Sentence denotes Furthermore, the resolution of 68 Ga-labeled tracers is physically limited because of positron range effects.
T55 8469-8578 Sentence denotes Furthermore, the resolution of 68 Ga-labeled tracers is physically limited because of positron range effects.
T56 8579-8696 Sentence denotes In contrast, 18 F labels avoid these intrinsic difficulties and can be produced at high yields in central cyclotrons.
T56 8579-8696 Sentence denotes In contrast, 18 F labels avoid these intrinsic difficulties and can be produced at high yields in central cyclotrons.
T57 8697-8958 Sentence denotes Fluorine-18-PSMA-1007 has been recently used by us in the Nuclear Medicine Department of "Evangelismos" general hospital of Athens and our experience so far showed favorable results, with high image resolution acquisitions and lesions which showed PSMA avidity.
T57 8697-8958 Sentence denotes Fluorine-18-PSMA-1007 has been recently used by us in the Nuclear Medicine Department of "Evangelismos" general hospital of Athens and our experience so far showed favorable results, with high image resolution acquisitions and lesions which showed PSMA avidity.
T58 8959-9073 Sentence denotes Fluorine-18-PSMA-1007 PET/CT imaging was carried out with a dual phase protocol, consisting of two separate scans.
T58 8959-9073 Sentence denotes Fluorine-18-PSMA-1007 PET/CT imaging was carried out with a dual phase protocol, consisting of two separate scans.
T59 9074-9245 Sentence denotes One (early scan) at 60min post injection starting from the diaphragm to the middle of the thighs and the late scan at 180min from the dome of the skull to the knee joints.
T59 9074-9245 Sentence denotes One (early scan) at 60min post injection starting from the diaphragm to the middle of the thighs and the late scan at 180min from the dome of the skull to the knee joints.
T60 9246-9298 Sentence denotes Patients were asked to urine before the examination.
T60 9246-9298 Sentence denotes Patients were asked to urine before the examination.
T61 9299-9502 Sentence denotes Images were acquired with a scan time of 3min per bed position on a General Electric PET/CT system and the image reconstruction was performed by the standard software method provided by the manufacturer.
T61 9299-9502 Sentence denotes Images were acquired with a scan time of 3min per bed position on a General Electric PET/CT system and the image reconstruction was performed by the standard software method provided by the manufacturer.
T62 9503-9634 Sentence denotes A low dose CT scan, without a contrast agent, was performed before the PET scan in order to be used for the attenuation correction.
T62 9503-9634 Sentence denotes A low dose CT scan, without a contrast agent, was performed before the PET scan in order to be used for the attenuation correction.
T63 9635-9757 Sentence denotes Administered activities were calculated based on the department's protocols with a suggested injected activity of 4MBq/kg.
T63 9635-9757 Sentence denotes Administered activities were calculated based on the department's protocols with a suggested injected activity of 4MBq/kg.
T64 9758-9948 Sentence denotes Any areas of focally increased radiotracer uptake, at both the early and late PET scans, were considered as abnormal, despite the presence or absence of morphological changes of the CT scan.
T64 9758-9948 Sentence denotes Any areas of focally increased radiotracer uptake, at both the early and late PET scans, were considered as abnormal, despite the presence or absence of morphological changes of the CT scan.
T65 9949-10272 Sentence denotes The normal distribution of the radiotracer was taken under consideration, which includes mainly the liver and the gallbladder, as it has hepatobiliary clearance rather than renal, the spleen, the pancreas, the submandibular, sublingual, lacrimal and parotid glands, the kidneys, the urinary bladder and the small intestine.
T65 9949-10272 Sentence denotes The normal distribution of the radiotracer was taken under consideration, which includes mainly the liver and the gallbladder, as it has hepatobiliary clearance rather than renal, the spleen, the pancreas, the submandibular, sublingual, lacrimal and parotid glands, the kidneys, the urinary bladder and the small intestine.
T66 10273-10351 Sentence denotes The maximum standardized uptake value (SUVmax) was calculated for each lesion.
T66 10273-10351 Sentence denotes The maximum standardized uptake value (SUVmax) was calculated for each lesion.
T67 10352-10500 Sentence denotes A typical case of a 78 years man with PCa having PSA 7,3ng/mL and also having Paget's disease was tested by the above procedure for initial staging.
T67 10352-10500 Sentence denotes A typical case of a 78 years man with PCa having PSA 7,3ng/mL and also having Paget's disease was tested by the above procedure for initial staging.
T68 10501-10626 Sentence denotes The 18 F-PSMA-1007 PET/CT imaging revealed diffusely increased radiotracer uptake in the bones of the pelvis with a SUVmax 9.
T68 10501-10626 Sentence denotes The 18 F-PSMA-1007 PET/CT imaging revealed diffusely increased radiotracer uptake in the bones of the pelvis with a SUVmax 9.
T69 10627-10783 Sentence denotes The CT imaging of the pelvis was consistent with Paget's disease, with diffuse mixed osteosclerotic and osteolytic lesions, accompanied with bone expansion.
T69 10627-10783 Sentence denotes The CT imaging of the pelvis was consistent with Paget's disease, with diffuse mixed osteosclerotic and osteolytic lesions, accompanied with bone expansion.
T70 10784-11022 Sentence denotes The primary PCa was also revealed with focally increased radiotracer uptake in the left prostatic lobe with a SUVmax 19, as well as a second small focus of pathologically increased PSMA uptake in the right prostatic lobe with a SUVmax 23.
T70 10784-11022 Sentence denotes The primary PCa was also revealed with focally increased radiotracer uptake in the left prostatic lobe with a SUVmax 19, as well as a second small focus of pathologically increased PSMA uptake in the right prostatic lobe with a SUVmax 23.
T71 11023-11150 Sentence denotes Another patient 79 years old, with PCa was studied with 18 F-choline PET/CT which showed diffuse bone metastasis in the pelvis.
T71 11023-11150 Sentence denotes Another patient 79 years old, with PCa was studied with 18 F-choline PET/CT which showed diffuse bone metastasis in the pelvis.
T72 11151-11178 Sentence denotes He had PSA level, 412ng/mL.
T72 11151-11178 Sentence denotes He had PSA level, 412ng/mL.
T73 11179-11375 Sentence denotes The 18 F-PSMA-1007 PET/CT imaging showed multiple foci of increased radiotracer uptake throughout the whole skeleton, including the skull, both humerus and femoral bones with indicative SUVmax 26.
T73 11179-11375 Sentence denotes The 18 F-PSMA-1007 PET/CT imaging showed multiple foci of increased radiotracer uptake throughout the whole skeleton, including the skull, both humerus and femoral bones with indicative SUVmax 26.
T74 11376-11421 Sentence denotes Computed tomography showed rather similar BM.
T74 11376-11421 Sentence denotes Computed tomography showed rather similar BM.
T75 11422-11549 Sentence denotes There were also lymph nodes metastases at the left internal mammary chain as well as the left inguinal areas, with a SUVmax 25.
T75 11422-11549 Sentence denotes There were also lymph nodes metastases at the left internal mammary chain as well as the left inguinal areas, with a SUVmax 25.
T76 11550-11855 Sentence denotes The first case indicated that 18 F-PSMA PET/CT could easily differentiate PCa BM from Paget's disease, however benign conditions such as Paget's disease may also show PSMA uptake and the second case that 18 F-PSMA PET/CT scan was more sensitive than the 18 F-choline PET/CT scan, with high quality images.
T76 11550-11855 Sentence denotes The first case indicated that 18 F-PSMA PET/CT could easily differentiate PCa BM from Paget's disease, however benign conditions such as Paget's disease may also show PSMA uptake and the second case that 18 F-PSMA PET/CT scan was more sensitive than the 18 F-choline PET/CT scan, with high quality images.
T77 11856-11961 Sentence denotes According to other authors the SUVmax value of BM in PCa was 16.57±23.59 using the 18 F-PSMA PET/CT scan.
T77 11856-11961 Sentence denotes According to other authors the SUVmax value of BM in PCa was 16.57±23.59 using the 18 F-PSMA PET/CT scan.
T78 11962-12113 Sentence denotes This imaging modality in accordance to other authors is better than 68 Ga-labelled PSMA-ligands and can better differentiate BM from healing fractures.
T78 11962-12113 Sentence denotes This imaging modality in accordance to other authors is better than 68 Ga-labelled PSMA-ligands and can better differentiate BM from healing fractures.
T79 12114-12201 Sentence denotes Very recently a novel PET radiopharmaceutical has been approved both in USA and Europe:
T79 12114-12201 Sentence denotes Very recently a novel PET radiopharmaceutical has been approved both in USA and Europe:
T80 12202-12280 Sentence denotes 18 F-fluciclovine (trans-1-amino-3-[18 F] fluoro-cyclobutane carboxylic acid).
T80 12202-12280 Sentence denotes 18 F-fluciclovine (trans-1-amino-3-[18 F] fluoro-cyclobutane carboxylic acid).
T81 12281-12450 Sentence denotes Fluorine-18-fluciclovine is a synthetic amino acid that is transported by multiple sodium-dependent and sodium-independent channels found to be upregulated in PCa cells.
T81 12281-12450 Sentence denotes Fluorine-18-fluciclovine is a synthetic amino acid that is transported by multiple sodium-dependent and sodium-independent channels found to be upregulated in PCa cells.
T82 12451-12590 Sentence denotes The main indication of use includes the detection and localization of PCa recurrence in patients with a rising PSA following prior therapy.
T82 12451-12590 Sentence denotes The main indication of use includes the detection and localization of PCa recurrence in patients with a rising PSA following prior therapy.
T83 12591-12774 Sentence denotes The main advantages of 18 F-fluciclovine are the low urinary excretion, which allows for better evaluation of prostate bed and the low uptake in inflammatory cells (e.g. macrophages).
T83 12591-12774 Sentence denotes The main advantages of 18 F-fluciclovine are the low urinary excretion, which allows for better evaluation of prostate bed and the low uptake in inflammatory cells (e.g. macrophages).
T84 12775-13004 Sentence denotes There are no studies in the literature comparing 18 F-PSMA to 18 F-fluciclovine, however two studies comparing 18 F-fluciclovine to 68 Ga-PSMA, showed better performance for 68 Ga-PSMA in PCa patients with biochemical recurrence.
T84 12775-13004 Sentence denotes There are no studies in the literature comparing 18 F-PSMA to 18 F-fluciclovine, however two studies comparing 18 F-fluciclovine to 68 Ga-PSMA, showed better performance for 68 Ga-PSMA in PCa patients with biochemical recurrence.
T85 13005-13169 Sentence denotes So, 18 F-PSMA-1007 PET/CT imaging seems to be very promising in staging and restaging patients with PCa, especially when biochemical relapse is under consideration.
T85 13005-13169 Sentence denotes So, 18 F-PSMA-1007 PET/CT imaging seems to be very promising in staging and restaging patients with PCa, especially when biochemical relapse is under consideration.
T86 13170-13346 Sentence denotes Although it seems to perform better than other imaging modalities like bone scan, 18 F-FDG PET/CT or 18 F-choline PET/CT, its high cost and low availability must be considered.
T86 13170-13346 Sentence denotes Although it seems to perform better than other imaging modalities like bone scan, 18 F-FDG PET/CT or 18 F-choline PET/CT, its high cost and low availability must be considered.
T87 13347-13497 Sentence denotes Further large studies need to be conducted in order to evaluate the accuracy and the predictive values of this method, emphasizing on bone metastases.
T87 13347-13497 Sentence denotes Further large studies need to be conducted in order to evaluate the accuracy and the predictive values of this method, emphasizing on bone metastases.