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PubMed:30718974 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
T1 0-123 Sentence denotes Alteration in Inflammatory Responses and Cytochrome P450 Expression of Porcine Jejunal Cells by Drinking Water Supplements.
T1 0-123 Sentence denotes Alteration in Inflammatory Responses and Cytochrome P450 Expression of Porcine Jejunal Cells by Drinking Water Supplements.
T2 124-216 Sentence denotes The intestinal epithelium is the first determining barrier to the drugs administered per os.
T2 124-216 Sentence denotes The intestinal epithelium is the first determining barrier to the drugs administered per os.
T3 217-443 Sentence denotes Cytochrome P450 (CYP) enzymes are substantial in the initial step of xenobiotic metabolism; therefore, intestinal CYP enzyme activities could be an important influencing factor of the oral utilization of xenobiotic substances.
T3 217-443 Sentence denotes Cytochrome P450 (CYP) enzymes are substantial in the initial step of xenobiotic metabolism; therefore, intestinal CYP enzyme activities could be an important influencing factor of the oral utilization of xenobiotic substances.
T4 444-576 Sentence denotes In this study, the effect of four drinking water supplements on CYP mRNA levels of porcine intestinal epithelial cells was examined.
T4 444-576 Sentence denotes In this study, the effect of four drinking water supplements on CYP mRNA levels of porcine intestinal epithelial cells was examined.
T5 577-716 Sentence denotes Further goal of the study is to describe the effect of these feed additives on the proinflammatory response of the LPS-treated enterocytes.
T5 577-716 Sentence denotes Further goal of the study is to describe the effect of these feed additives on the proinflammatory response of the LPS-treated enterocytes.
T6 717-832 Sentence denotes The nontransformed porcine intestinal epithelial cells (IPEC-J2) were grown on six-well polyester membrane inserts.
T6 717-832 Sentence denotes The nontransformed porcine intestinal epithelial cells (IPEC-J2) were grown on six-well polyester membrane inserts.
T7 833-1049 Sentence denotes Cell cultures were treated with LPS (10 μg/ml), β-glucan (5 and 50 μg/ml), sanguinarine-containing additive (5 and 50 μg/ml), drinking water acidifier (0.1 and 1 μl/ml), and fulvic acid (25 and 250 μg/ml) for 1 hour.
T7 833-1049 Sentence denotes Cell cultures were treated with LPS (10 μg/ml), β-glucan (5 and 50 μg/ml), sanguinarine-containing additive (5 and 50 μg/ml), drinking water acidifier (0.1 and 1 μl/ml), and fulvic acid (25 and 250 μg/ml) for 1 hour.
T8 1050-1148 Sentence denotes Cells were washed with culture medium and incubated for additional 1 h before total RNA isolation.
T8 1050-1148 Sentence denotes Cells were washed with culture medium and incubated for additional 1 h before total RNA isolation.
T9 1149-1229 Sentence denotes IL-6, IL-8, TNF-α, HSP70, CYP1A1, CYP1A2, and CYP3A29 mRNA levels were measured.
T9 1149-1229 Sentence denotes IL-6, IL-8, TNF-α, HSP70, CYP1A1, CYP1A2, and CYP3A29 mRNA levels were measured.
T10 1230-1298 Sentence denotes The LPS treatment upregulated the gene expression of IL-8 and TNF-α.
T10 1230-1298 Sentence denotes The LPS treatment upregulated the gene expression of IL-8 and TNF-α.
T11 1299-1438 Sentence denotes The relative gene expression of IL-6 remained unchanged and TNF-α and HSP70 were downregulated after the treatment with each feed additive.
T11 1299-1438 Sentence denotes The relative gene expression of IL-6 remained unchanged and TNF-α and HSP70 were downregulated after the treatment with each feed additive.
T12 1439-1571 Sentence denotes CYP1A1 and CYP1A2 expressions increased after sanguinarine-containing solution, fulvic acid, and drinking water acidifier treatment.
T12 1439-1571 Sentence denotes CYP1A1 and CYP1A2 expressions increased after sanguinarine-containing solution, fulvic acid, and drinking water acidifier treatment.
T13 1572-1724 Sentence denotes None of the treatments changed the gene expression of CYP3A29, responsible for the metabolism of the majority of drug substances used in swine industry.
T13 1572-1724 Sentence denotes None of the treatments changed the gene expression of CYP3A29, responsible for the metabolism of the majority of drug substances used in swine industry.
T14 1725-1943 Sentence denotes The feed additive substances inhibited the expression of proinflammatory mediators HSP70 and TNF-α; however, β-glucan and fulvic acid elevated the production of the chemokine IL-8 mRNA in endotoxin-treated enterocytes.
T14 1725-1943 Sentence denotes The feed additive substances inhibited the expression of proinflammatory mediators HSP70 and TNF-α; however, β-glucan and fulvic acid elevated the production of the chemokine IL-8 mRNA in endotoxin-treated enterocytes.
T15 1944-2077 Sentence denotes All acidic supplements increased the expression of CYP1A1 gene; their constituents may serve as a ligand of CYP1A1 nuclear receptors.
T15 1944-2077 Sentence denotes All acidic supplements increased the expression of CYP1A1 gene; their constituents may serve as a ligand of CYP1A1 nuclear receptors.