| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-134 |
Sentence |
denotes |
Common proteomic profiles of induced pluripotent stem cell-derived three-dimensional neurons and brain tissue from Alzheimer patients. |
| T1 |
0-134 |
Sentence |
denotes |
Common proteomic profiles of induced pluripotent stem cell-derived three-dimensional neurons and brain tissue from Alzheimer patients. |
| T2 |
135-290 |
Sentence |
denotes |
We established a unique platform for proteomic analysis of cultured three-dimensional (3D) neurons and brain tissue from Alzheimer's disease (AD) patients. |
| T2 |
135-290 |
Sentence |
denotes |
We established a unique platform for proteomic analysis of cultured three-dimensional (3D) neurons and brain tissue from Alzheimer's disease (AD) patients. |
| T3 |
291-467 |
Sentence |
denotes |
We collected peripheral blood mononuclear cells (PBMC), converted PBMC to induced pluripotent stem cell (iPSC) lines, and differentiated the iPSC into human 3D neuro-spheroids. |
| T3 |
291-467 |
Sentence |
denotes |
We collected peripheral blood mononuclear cells (PBMC), converted PBMC to induced pluripotent stem cell (iPSC) lines, and differentiated the iPSC into human 3D neuro-spheroids. |
| T4 |
468-652 |
Sentence |
denotes |
The postmortem brain tissue from the superior frontal cortex, inferior frontal cortex and cerebellum area of the AD patients was compared to the same regions from the control subjects. |
| T4 |
468-652 |
Sentence |
denotes |
The postmortem brain tissue from the superior frontal cortex, inferior frontal cortex and cerebellum area of the AD patients was compared to the same regions from the control subjects. |
| T5 |
653-840 |
Sentence |
denotes |
Proteomic analysis of 3D neuro-spheroids derived from AD subjects revealed the alteration of a number of proteins involved in axon growth, mitochondrial function, and antioxidant defense. |
| T5 |
653-840 |
Sentence |
denotes |
Proteomic analysis of 3D neuro-spheroids derived from AD subjects revealed the alteration of a number of proteins involved in axon growth, mitochondrial function, and antioxidant defense. |
| T6 |
841-1028 |
Sentence |
denotes |
Similar analysis of post-mortem AD brain tissue revealed significant alteration in proteins involved in oxidative stress, neuro-inflammation, along with proteins related to axonal injury. |
| T6 |
841-1028 |
Sentence |
denotes |
Similar analysis of post-mortem AD brain tissue revealed significant alteration in proteins involved in oxidative stress, neuro-inflammation, along with proteins related to axonal injury. |
| T7 |
1029-1197 |
Sentence |
denotes |
These results clearly indicate that the dysfunction of 3D neurons from AD patients in our in vitro environment is comparable to the post-mortem AD brain tissue in vivo. |
| T7 |
1029-1197 |
Sentence |
denotes |
These results clearly indicate that the dysfunction of 3D neurons from AD patients in our in vitro environment is comparable to the post-mortem AD brain tissue in vivo. |
| T8 |
1198-1442 |
Sentence |
denotes |
In conclusion, our study revealed a number of candidate proteins that have important implications in AD pathogenesis and supports the notion that the iPSC-derived 3D neuronal system functions as a model to examine novel aspects of AD pathology. |
| T8 |
1198-1442 |
Sentence |
denotes |
In conclusion, our study revealed a number of candidate proteins that have important implications in AD pathogenesis and supports the notion that the iPSC-derived 3D neuronal system functions as a model to examine novel aspects of AD pathology. |
| T9 |
1443-1456 |
Sentence |
denotes |
SIGNIFICANCE: |
| T9 |
1443-1456 |
Sentence |
denotes |
SIGNIFICANCE: |
| T10 |
1457-1738 |
Sentence |
denotes |
In this study, we present a unique platform for proteomic analysis of induced pluripotent stem cell-derived three dimensional (3D) neurons and compare the results to those from three regions of post-mortem brain tissue from Alzheimer's disease patients and normal control subjects. |
| T10 |
1457-1738 |
Sentence |
denotes |
In this study, we present a unique platform for proteomic analysis of induced pluripotent stem cell-derived three dimensional (3D) neurons and compare the results to those from three regions of post-mortem brain tissue from Alzheimer's disease patients and normal control subjects. |
| T11 |
1739-1893 |
Sentence |
denotes |
Our results show that the dysfunction of 3D neurons from AD patients in our in vitro environment is comparable to the post-mortem AD brain tissue in vivo. |
| T11 |
1739-1893 |
Sentence |
denotes |
Our results show that the dysfunction of 3D neurons from AD patients in our in vitro environment is comparable to the post-mortem AD brain tissue in vivo. |
| T12 |
1894-1994 |
Sentence |
denotes |
Our results revealed several candidate proteins that have important implications in AD pathogenesis. |
| T12 |
1894-1994 |
Sentence |
denotes |
Our results revealed several candidate proteins that have important implications in AD pathogenesis. |
