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PubMed:29387348 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes AGE-induced neuronal cell death is enhanced in G2019S LRRK2 mutation with increased RAGE expression.
T1 0-100 Sentence denotes AGE-induced neuronal cell death is enhanced in G2019S LRRK2 mutation with increased RAGE expression.
T2 101-112 Sentence denotes Background:
T2 101-112 Sentence denotes Background:
T3 113-250 Sentence denotes Leucine-rich repeat kinase 2 (LRRK2) mutations represent the most common genetic cause of sporadic and familial Parkinson's disease (PD).
T3 113-250 Sentence denotes Leucine-rich repeat kinase 2 (LRRK2) mutations represent the most common genetic cause of sporadic and familial Parkinson's disease (PD).
T4 251-371 Sentence denotes Especially, LRRK2 G2019S missense mutation has been identified as the most prevalent genetic cause in the late-onset PD.
T4 251-371 Sentence denotes Especially, LRRK2 G2019S missense mutation has been identified as the most prevalent genetic cause in the late-onset PD.
T5 372-561 Sentence denotes Advanced glycation end products (AGEs) are produced in high amounts in diabetes and diverse aging-related disorders, such as cardiovascular disease, renal disease, and neurological disease.
T5 372-561 Sentence denotes Advanced glycation end products (AGEs) are produced in high amounts in diabetes and diverse aging-related disorders, such as cardiovascular disease, renal disease, and neurological disease.
T6 562-679 Sentence denotes AGEs trigger intracellular signaling pathway associated with oxidative stress and inflammation as well as cell death.
T6 562-679 Sentence denotes AGEs trigger intracellular signaling pathway associated with oxidative stress and inflammation as well as cell death.
T7 680-780 Sentence denotes RAGE, receptor of AGEs, is activated by interaction with AGEs and mediates AGE-induced cytotoxicity.
T7 680-780 Sentence denotes RAGE, receptor of AGEs, is activated by interaction with AGEs and mediates AGE-induced cytotoxicity.
T8 781-862 Sentence denotes Whether AGE and RAGE are involved in the pathogenesis of mutant LRRK2 is unknown.
T8 781-862 Sentence denotes Whether AGE and RAGE are involved in the pathogenesis of mutant LRRK2 is unknown.
T9 863-871 Sentence denotes Methods:
T9 863-871 Sentence denotes Methods:
T10 872-1120 Sentence denotes Using cell lines transfected with mutant LRRK2 as well as primary neuronal cultures derived from LRRK2 wild-type (WT) and G2019S transgenic mice, we compared the impact of AGE treatment on the survival of control and mutant cells by immunostaining.
T10 872-1120 Sentence denotes Using cell lines transfected with mutant LRRK2 as well as primary neuronal cultures derived from LRRK2 wild-type (WT) and G2019S transgenic mice, we compared the impact of AGE treatment on the survival of control and mutant cells by immunostaining.
T11 1121-1232 Sentence denotes We also examined the levels of RAGE proteins in the brains of transgenic mice and PD patients by western blots.
T11 1121-1232 Sentence denotes We also examined the levels of RAGE proteins in the brains of transgenic mice and PD patients by western blots.
T12 1233-1241 Sentence denotes Results:
T12 1233-1241 Sentence denotes Results:
T13 1242-1361 Sentence denotes We show that LRRK2 G2019S mutant-expressing neurons were more sensitive to AGE-induced cell death compared to controls.
T13 1242-1361 Sentence denotes We show that LRRK2 G2019S mutant-expressing neurons were more sensitive to AGE-induced cell death compared to controls.
T14 1362-1463 Sentence denotes Furthermore, we found that the levels of RAGE proteins were upregulated in LRRK2 G2019S mutant cells.
T14 1362-1463 Sentence denotes Furthermore, we found that the levels of RAGE proteins were upregulated in LRRK2 G2019S mutant cells.
T15 1464-1476 Sentence denotes Conclusions:
T15 1464-1476 Sentence denotes Conclusions:
T16 1477-1609 Sentence denotes These data suggest that enhanced AGE-RAGE interaction contributes to LRRK2 G2019S mutation-mediated progressive neuronal loss in PD.
T16 1477-1609 Sentence denotes These data suggest that enhanced AGE-RAGE interaction contributes to LRRK2 G2019S mutation-mediated progressive neuronal loss in PD.