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PubMed:29291351 JSONTXT 2 Projects

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Id Subject Object Predicate Lexical cue
T1 0-83 Sentence denotes The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis.
T1 0-83 Sentence denotes The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis.
T2 84-192 Sentence denotes Nonalcoholic steatohepatitis (NASH) is a common clinical condition that can lead to advanced liver diseases.
T2 84-192 Sentence denotes Nonalcoholic steatohepatitis (NASH) is a common clinical condition that can lead to advanced liver diseases.
T3 193-313 Sentence denotes Lack of effective pharmacotherapies for NASH is largely attributable to an incomplete understanding of its pathogenesis.
T3 193-313 Sentence denotes Lack of effective pharmacotherapies for NASH is largely attributable to an incomplete understanding of its pathogenesis.
T4 314-399 Sentence denotes The deubiquitinase cylindromatosis (CYLD) plays key roles in inflammation and cancer.
T4 314-399 Sentence denotes The deubiquitinase cylindromatosis (CYLD) plays key roles in inflammation and cancer.
T5 400-471 Sentence denotes Here we identified CYLD as a suppressor of NASH in mice and in monkeys.
T5 400-471 Sentence denotes Here we identified CYLD as a suppressor of NASH in mice and in monkeys.
T6 472-577 Sentence denotes CYLD is progressively degraded upon interaction with the E3 ligase TRIM47 in proportion to NASH severity.
T6 472-577 Sentence denotes CYLD is progressively degraded upon interaction with the E3 ligase TRIM47 in proportion to NASH severity.
T7 578-775 Sentence denotes We observed that overexpression of Cyld in hepatocytes concomitantly inhibits lipid accumulation, insulin resistance, inflammation and fibrosis in mice with NASH induced in an experimental setting.
T7 578-775 Sentence denotes We observed that overexpression of Cyld in hepatocytes concomitantly inhibits lipid accumulation, insulin resistance, inflammation and fibrosis in mice with NASH induced in an experimental setting.
T8 776-945 Sentence denotes Mechanistically, CYLD interacts directly with the kinase TAK1 and removes its K63-linked polyubiquitin chain, which blocks downstream activation of the JNK-p38 cascades.
T8 776-945 Sentence denotes Mechanistically, CYLD interacts directly with the kinase TAK1 and removes its K63-linked polyubiquitin chain, which blocks downstream activation of the JNK-p38 cascades.
T9 946-1154 Sentence denotes Notably, reconstitution of hepatic CYLD expression effectively reverses disease progression in mice with dietary or genetically induced NASH and in high-fat diet-fed monkeys predisposed to metabolic syndrome.
T9 946-1154 Sentence denotes Notably, reconstitution of hepatic CYLD expression effectively reverses disease progression in mice with dietary or genetically induced NASH and in high-fat diet-fed monkeys predisposed to metabolic syndrome.
T10 1155-1324 Sentence denotes Collectively, our findings demonstrate that CYLD mitigates NASH severity and identify the CYLD-TAK1 axis as a promising therapeutic target for management of the disease.
T10 1155-1324 Sentence denotes Collectively, our findings demonstrate that CYLD mitigates NASH severity and identify the CYLD-TAK1 axis as a promising therapeutic target for management of the disease.