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PubMed:29223705 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T1 0-114 Sentence denotes Functional hepatocyte clusters on bioactive blend silk matrices towards generating bioartificial liver constructs.
T1 0-114 Sentence denotes Functional hepatocyte clusters on bioactive blend silk matrices towards generating bioartificial liver constructs.
T2 115-327 Sentence denotes The creation of in vitro functional hepatic tissue simulating micro-environmental niche of native liver is a keen area of research due to its demand in bioartificial liver (BAL) and cell-based tissue engineering.
T2 115-327 Sentence denotes The creation of in vitro functional hepatic tissue simulating micro-environmental niche of native liver is a keen area of research due to its demand in bioartificial liver (BAL) and cell-based tissue engineering.
T3 328-594 Sentence denotes Here, we investigated the potential of novel blend (BA) silk scaffold fabricated by blending mulberry (Bombyx mori, BM) silk fibroin with cell adhesion motif (RGD) rich non-mulberry (Antheraea assamensis, AA) silk fibroin, in generating a functional liver construct.
T3 328-594 Sentence denotes Here, we investigated the potential of novel blend (BA) silk scaffold fabricated by blending mulberry (Bombyx mori, BM) silk fibroin with cell adhesion motif (RGD) rich non-mulberry (Antheraea assamensis, AA) silk fibroin, in generating a functional liver construct.
T4 595-800 Sentence denotes Three-dimensional (3D) porous silk scaffolds (BM, AA and BA) were physico-chemically characterized and functionally evaluated using human hepatocarcinoma cells (HepG2) and primary neonatal rat hepatocytes.
T4 595-800 Sentence denotes Three-dimensional (3D) porous silk scaffolds (BM, AA and BA) were physico-chemically characterized and functionally evaluated using human hepatocarcinoma cells (HepG2) and primary neonatal rat hepatocytes.
T5 801-943 Sentence denotes The growth and distribution of hepatocytes within the scaffolds were tracked by FESEM, alamar blue proliferation assay and live/dead staining.
T5 801-943 Sentence denotes The growth and distribution of hepatocytes within the scaffolds were tracked by FESEM, alamar blue proliferation assay and live/dead staining.
T6 944-1085 Sentence denotes Hemocompatible BA scaffolds supported the formation of high density hepatocyte clusters, facilitating cell-matrix and cell-cell interactions.
T6 944-1085 Sentence denotes Hemocompatible BA scaffolds supported the formation of high density hepatocyte clusters, facilitating cell-matrix and cell-cell interactions.
T7 1086-1263 Sentence denotes Blend scaffolds evinced enhanced liver-specific functions of cultured hepatocytes in terms of albumin synthesis, urea synthesis and cytochrome P450 enzyme activity over 21 days.
T7 1086-1263 Sentence denotes Blend scaffolds evinced enhanced liver-specific functions of cultured hepatocytes in terms of albumin synthesis, urea synthesis and cytochrome P450 enzyme activity over 21 days.
T8 1264-1367 Sentence denotes Subcutaneous implantation of scaffolds demonstrated minimal macrophage infiltration in blend scaffolds.
T8 1264-1367 Sentence denotes Subcutaneous implantation of scaffolds demonstrated minimal macrophage infiltration in blend scaffolds.
T9 1368-1559 Sentence denotes These findings substantiate that the integral property of blend (BA) scaffold offers a befitting environment by influencing spheroidal growth of hepatocytes with enhanced biological activity.
T9 1368-1559 Sentence denotes These findings substantiate that the integral property of blend (BA) scaffold offers a befitting environment by influencing spheroidal growth of hepatocytes with enhanced biological activity.
T10 1560-1735 Sentence denotes Collectively, the present study provides a new 3D bio-matrix niche for growing functional liver cells that would have future prospects in BAL as well as regenerative medicine.
T10 1560-1735 Sentence denotes Collectively, the present study provides a new 3D bio-matrix niche for growing functional liver cells that would have future prospects in BAL as well as regenerative medicine.
T11 1736-1762 Sentence denotes STATEMENT OF SIGNIFICANCE:
T11 1736-1762 Sentence denotes STATEMENT OF SIGNIFICANCE:
T12 1763-1878 Sentence denotes An end stage liver disease called cirrhosis perturbs the self-healing ability and physiological functions of liver.
T12 1763-1878 Sentence denotes An end stage liver disease called cirrhosis perturbs the self-healing ability and physiological functions of liver.
T13 1879-2097 Sentence denotes Due to the scarcity of healthy donors, a functional in vitro hepatic construct retaining the liver-specific functions is in great demand for its prospects in bioartificial liver (BAL) and cell-based tissue engineering.
T13 1879-2097 Sentence denotes Due to the scarcity of healthy donors, a functional in vitro hepatic construct retaining the liver-specific functions is in great demand for its prospects in bioartificial liver (BAL) and cell-based tissue engineering.
T14 2098-2237 Sentence denotes Physicochemical attributes of a matrix influence the behavior of cultured hepatocytes in terms of attachment, morphology and functionality.
T14 2098-2237 Sentence denotes Physicochemical attributes of a matrix influence the behavior of cultured hepatocytes in terms of attachment, morphology and functionality.
T15 2238-2365 Sentence denotes Mulberry and non-mulberry silk fibroin presents unique amino acid sequence with difference in hydrophobicity and crystallinity.
T15 2238-2365 Sentence denotes Mulberry and non-mulberry silk fibroin presents unique amino acid sequence with difference in hydrophobicity and crystallinity.
T16 2366-2585 Sentence denotes Considering this, the present study focuses on the development of a suitable three-dimensional (3D) bioactive matrix incorporating both mulberry silk fibroin and cell adhesion motif (RGD) rich non-mulberry silk fibroin.
T16 2366-2585 Sentence denotes Considering this, the present study focuses on the development of a suitable three-dimensional (3D) bioactive matrix incorporating both mulberry silk fibroin and cell adhesion motif (RGD) rich non-mulberry silk fibroin.
T17 2586-2758 Sentence denotes Porous silk blend scaffolds facilitated the formation of hepatocyte clusters with enhanced liver-specific functions emphasizing both cell-cell and cell-matrix interactions.
T17 2586-2758 Sentence denotes Porous silk blend scaffolds facilitated the formation of hepatocyte clusters with enhanced liver-specific functions emphasizing both cell-cell and cell-matrix interactions.
T18 2759-2933 Sentence denotes Hemocompatibility and integral property of blend scaffolds offers a biological niche for seeding functional liver cells that would have future prospects in biohybrid devices.
T18 2759-2933 Sentence denotes Hemocompatibility and integral property of blend scaffolds offers a biological niche for seeding functional liver cells that would have future prospects in biohybrid devices.